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http://dx.doi.org/10.7314/APJCP.2014.15.15.6275

Efficacy and Tolerance of Pegaspargase-Based Chemotherapy in Patients with Nasal-Type Extranodal NK/T-Cell Lymphoma: a Pilot Study  

Wen, Jing-Yun (Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University)
Li, Mai (Department of Biotechnology, Guangdong Food and Drug Vocational College)
Li, Xing (Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University)
Chen, Jie (Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University)
Lin, Qu (Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University)
Ma, Xiao-Kun (Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University)
Dong, Min (Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University)
Wei, Li (Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University)
Chen, Zhan-Hong (Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University)
Wu, Xiang-Yuan (Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.15, 2014 , pp. 6275-6281 More about this Journal
Abstract
Nasal-type extranodal natural killer (NK)/T-cell lymphoma (ENKL) is a highly invasive cancer with a poor prognosis. More effective and safer treatment regimens for ENKL are needed. Pegaspargase (PEG-Asp) has a similar mechanism of action to L-asparaginase (L-Asp), but presents lower antigenicity. The aim of the present research was to evaluate the safety profile and the latent efficacy of a PEG-Asp-based treatment regimen in patients with ENKL. Data collected from 20 patients with histologically confirmed ENKL, admitted to the Third Affiliated Hospital of Sun Yat-Sen University from January 2009 to August 2013, were included in the study. All patients received $2500IU/m^2$/IM PEG-Asp on day 1 of every 21-day treatment cycle. Patients received combination chemotherapy with CHOP (n=5), EPOCH (n=7), GEMOX (n=7) or CHOP with bleomycin (n=1). After 2-5 treatment cycles (median, 4 cycles) of PEG-Asp-based chemotherapy, five patients (25%) showed a complete response (CR), and the overall response rate (ORR) was 60%. Grade 3/4 neutropenia occurred in fourteen patients (70%). Grade 3 alanine aminotransferase (ALT) elevation was observed in two. Grade 1-2 non-hematological toxicity consisted of activated partial thromboplastin time (APTT) elongation (n=9), hypofibrinogenemia (n=6), hypoproteinemia (n=17), hyperglycemia (n=3), and nausea (n=6). No allergic reactions were detected. No treatment related death was reported. Our results suggested that PEG-Asp-based chemotherapy presented an acceptable tolerance and a potential short-term outcome in patients with nasal-type ENKL.
Keywords
Nasal; type extranodal NK/T; cell lymphoma; pegaspargase; response rate; safety; L-asparaginase;
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