Distinct Pro-Apoptotic Properties of Zhejiang Saffron against Human Lung Cancer Via a Caspase-8-9-3 Cascade |
Liu, Dan-Dan
(Department of Basic Medicine, Zhejiang Medical College)
Ye, Yi-Lu (Department of Basic Medicine, Zhejiang Medical College) Zhang, Jing (Department of Basic Medicine, Zhejiang Medical College) Xu, Jia-Ni (Department of Basic Medicine, Zhejiang Medical College) Qian, Xiao-Dong (Department of Pharmacy, Huzhou Central Hospital) Zhang, Qi (Department of Basic Medicine, Zhejiang Medical College) |
1 | Ashrafi M, Bathaie SZ, Taghikhani M, et al (2005). The effect of carotenoids obtained from saffron on histone H1 structure and H1-DNA interaction. Int J Bio Macromol, 36, 246-52. DOI |
2 | Bakshi H, Sam S, Feroz A, et al (2009). Crocin from Kashmiri saffron (Crocus sativus) induces in vitro and in vivo xenograft growth inhibition of Dalton's lymphoma (DLA) in mice. Asian Pac J Cancer Prev, 10, 887-90. |
3 | Bakshi H, Sam S, Rozati R, et al (2010). DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from kashmiri saffron in a human pancreatic cancer cell line. Asian Pac J Cancer Prev, 11, 675-9. |
4 | Chen J, Han H, Chen M, et al (2014). Inactivated Sendai Virus strain Tianjin induces apoptosis in human breast cancer MDA-MB-231 cells. Asian Pac J Cancer Prev, 15, 5023-8. 과학기술학회마을 DOI |
5 | Coate LE, Shepherd FA (2010). Maintenance therapy in advanced non-small cell lung cancer. J Thorac Oncol, 5, 723-34. |
6 | Dhar A, Mehta S, Dhar G, et al (2009). Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther, 8, 315-23. DOI |
7 | Dziegiel P, Dumanska M, Forgacz J, et al (2004). Intensity of apoptosis as related to the expression of metallothionein (MT), caspase-3 (cas-3) and Ki-67 antigen and the survival time of patients with primary colorectal adenocarcinomas. Rocz Akad Med Bialymst, 49, 5-7. |
8 | Jiang H, Zhang L, Liu J, et al (2012). Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9. Cancer Gene Ther, 19, 684-9. DOI |
9 | Giaccio M (2004). Crocetin from saffron: an active component of an ancient spice. Crit Rev Food Sci Nutr, 44, 155-72. DOI |
10 | Grimaudo S, Meli M, Di Cristina A, et al (2013). The new iodoacetamidobenzofuran derivative TR120 decreases STAT5 expression and induces antitumor effects in imatinibsensitive and imatinib-resistant BCR-ABL-expressing leukemia cells. Anticancer Drugs, 24, 384-33. DOI |
11 | Joukar S, Najafipour H, Khaksari M, et al (2010). The effect of saffron consumption on biochemical and histopathological heart indices of rats with myocardial infarction. Cardiovasc Toxicol, 10, 66-71. DOI ScienceOn |
12 | Li CY, Huang WF, Wang QL, et al (2012). Crocetin induces cytotoxicity in colon cancer cells via p53-independent mechanisms. Asian Pac J Cancer Prev, 13, 3757-61. 과학기술학회마을 DOI |
13 | Samarghandian S, Tavakkol Afshari J, Davoodi S (2011). Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction. Appl Biochem Biotechnol, 164, 238-47. DOI |
14 | Magesh V, Singh JP, Selvendiran K, et al (2006). Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol Cell Bioch, 287, 127-35. DOI |
15 | Rezaee R, Hosseinzadeh H (2013). Safranal: from an aromatic natural product to a rewarding pharmacological agent. Iran J Basic Med Sci, 16, 12-26. |
16 | Samarghandian S, Boskabady MH, Davoodi S (2010). Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line. Pharmacogn Mag, 6, 309-14. DOI |
17 | Schmidt M, Betti G, Hensel A (2007). Saffron in phytotherapy: pharmacology and clinical uses. Wien Med Wochenschr, 157, 315-19. DOI |
18 | Sun J, Xu XM, Ni CZ, et al (2011). Crocin inhibits proliferation and nucleic acid synthesis and induces apoptosis in the human tongue squamous cell carcinoma cell line Tca8113. Asian Pac J Cancer Prev, 12, 2679-83. |
19 | Sun Y, Xu HJ, Zhao YX, et al (2013). Crocin exhibits antitumor effects on human leukemia HL-60 cells in vitro and in vivo. Evid Based Complement Alternat Med, 2013, 690164. |
20 | Tavakkol AJ, Brook A, Mousavi SH (2008). Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem Toxic, 46, 3443-7. DOI ScienceOn |
21 | Zhang Z, Wang CZ, Wen XD, et al (2013). Role of saffron and its constituents on cancer chemoprevention. Pharm Biol, 51, 920-4. DOI |
22 | Shepherd FA, Douillard JY, Blumenschein GR (2011). Immunotherapy for non-small cell lung cancer novel approaches to improve patient outcome. J Thorac Oncol, 6, 1763-73. DOI ScienceOn |
23 | Zou X, Liu SL, Zhou JY, et al (2012). Beta-asarone induces LoVo colon cancer cell apoptosis by up-regulation of caspases through a mitochondrial pathway in vitro and in vivo. Asian Pac J Cancer Prev, 13, 5291-8. 과학기술학회마을 DOI ScienceOn |
24 | Hoshyar R, Bathaie SZ, Sadeghizadeh M (2013). Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma AGS cells. DNA Cell Biol, 32, 50-7. DOI |
![]() |