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http://dx.doi.org/10.7314/APJCP.2014.15.15.6065

SLC35B2 Expression is Associated with a Poor Prognosis of Invasive Ductal Breast Carcinoma  

Chim-ong, Anongruk (Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University)
Thawornkuno, Charin (Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University)
Chavalitshewinkoon-Petmitr, Porntip (Department of Protozoology, Faculty of Tropical Medicine, Mahidol University)
Punyarit, Phaibul (Army Institute of Pathology, Phramongkutklao Medical Center)
Petmitr, Songsak (Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.15, 2014 , pp. 6065-6070 More about this Journal
Abstract
Background: Breast cancer is the most common malignancy in women worldwide, including Thailand, and is a major cause of mortality and morbidity, despite advances in diagnosis and treatment. Novel gene expression in breast cancer is a focus in searches for prognostic biomarkers and new therapeutic targets. Materials and Methods: The mRNA expression of novel B4GALT4, SLC35B2, and WDHD1 genes in breast cancer were examined in invasive ductal breast carcinoma (IDC) patients using quantitative real-time reverse transcription polymerase chain reaction (QRT-PCR). Results: Among these genes, increased expression of SLC35B2 mRNA was significantly associated with TNM stage III + IV of IDC (p<0.001). Hence, up-regulation of SLC35B2 may serve as a prognostic biomarker for poor prognosis, and is also a potential therapeutic target in breast cancer.
Keywords
Invasive ductal breast carcinoma; poor prognosis; SLC35B2;
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