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http://dx.doi.org/10.7314/APJCP.2014.15.15.5993

Functional Roles of Long Non-coding RNA in Human Breast Cancer  

Ye, Ni (College of Veterinary Medicine, Sichuan Agricultural University)
Wang, Bin (College of Veterinary Medicine, Sichuan Agricultural University)
Quan, Zi-Fang (College of Veterinary Medicine, Sichuan Agricultural University)
Cao, San-Jie (College of Veterinary Medicine, Sichuan Agricultural University)
Wen, Xin-Tian (College of Veterinary Medicine, Sichuan Agricultural University)
Huang, Yong (College of Veterinary Medicine, Sichuan Agricultural University)
Huang, Xiao-Bo (College of Veterinary Medicine, Sichuan Agricultural University)
Wu, Rui (College of Veterinary Medicine, Sichuan Agricultural University)
Ma, Xiao-Ping (College of Veterinary Medicine, Sichuan Agricultural University)
Yan, Qi-Gui (College of Veterinary Medicine, Sichuan Agricultural University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.15, 2014 , pp. 5993-5997 More about this Journal
Abstract
The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.
Keywords
Long non-coding RNAs; biological function; breast cancer; tumorigenic mechanism;
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