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http://dx.doi.org/10.7314/APJCP.2014.15.14.5597

Clinical Study on Safety of Cantharidin Sodium and Shenmai Injection Combined with Chemotherapy in Treating Patients with Breast Cancer Postoperatively  

Wang, Lin (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research)
Huang, Xin-En (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research)
Cao, Jie (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.14, 2014 , pp. 5597-5600 More about this Journal
Abstract
Objectives: To assess side effects on Cantharidin sodium and Shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively. Method: Patients with breast cancer receiving postoperative chemotherapy were retrospectively collected, and divided into four groups: group A with cantharidin sodium injection combined with chemotherapy; group B with Shenmai injection combined with chemotherapy; group C with both cantharidin sodium and Shenmai injection combined with chemotherapy; while group D (control group) received chemotherapy alone. All patients were administered docetaxel at a dose of $75mg/m^2$ on day 1, epirubicin hydrochloride at a dose of $60mg/m^2$ on day 1, and cyclophosphamide at a dose of $500mg/m^2$ on day 1 for 3 cycles (repeated at 21 day intervals). After ${\geq}$ three courses of treatment, quality of life and side effects were evaluated. Results: There were a total of 78 patients in this study, and the incidence of leukopenia and gastrointestinal reactions in groups A and B were lower than those in the control group and lowest in group C (p<0.05). Conclusions: Thus cantharidin sodium and Shenmai injection combined with chemotherapy reduce side effects and deserve to be further investigated in randomized clinical control trials.
Keywords
Cantharides sodium injection; Shenmai injection-chemotherapy; breast cancer treatment;
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1 Huang XE, Tian GY, Cao J, et al (2013). Pemetrexed as a component of first-, second- and third-line chemotherapy in treating patients with metastatic lung adenocarcinoma. Asian Pac J Cancer Prev, 14, 6663-7.   과학기술학회마을   DOI   ScienceOn
2 Li CG, Huang XE, Xu L, et al (2012). Clinical application of serum tumor associated material (TAM) from non-small celllung cancer patients. Asian Pac J Cancer Prev, 13, 301-4.   과학기술학회마을   DOI
3 Liu X-Y, Lai S-L, Guo X-F, Lao Y-R (2005). Shen-Mai injectionas an adjunct therapy to tumor chemotherapy a systematic review. Chinese J Evidence-Based Medicine, 1, 22-28.
4 Liu J, Huang XE, Tian GY, et al (2013). Phase II Study on safetyand efficacy of $Yadanzi^{(R)}$ (Javanica oil emulsion injection) combined with chemotherapy for patients with gastric cancer. Asian Pac J Cancer Prev, 14, 2009-12.   과학기술학회마을   DOI   ScienceOn
5 Lo LC, Chen CY, Chen ST, et al (2012). Therapeutic efficacy of traditional Chinese medicine, Shen-Mai San, in cancer patients undergoing chemotherapy or radiotherapy: study protocol for a randomized, double-blind, placebo-controlledtrial. Trials, 13, 232.   DOI
6 Qin CY, Maizhi Z (2000). Pattern, Cause, Pulse, and Treatment, Ancient Books of TCM, Beijing, China.
7 Shen B, Zheng MQ, Lu JW, et al (2013). CXCL12-CXCR4 promotes proliferation and invasion of pancreatic cancercells. Asian Pac J Cancer Prev, 14, 5403-8.   과학기술학회마을   DOI   ScienceOn
8 Shu JZ, Wang QR (2008). Meta analysis of the treatment for acute cerebral infarction with Shenmai injection andcompound salvia miltiorrhiza injection. Mod J Integ Trad Chin West Med, 17, 973-6.
9 Yu DS, Huang XE, Zhou JN, et al (2012). A comparative study on the value of anal preserving surgery for aged people with low rectal carcinoma in Jiangsu, China. Asian Pac J Cancer Prev, 13, 2339-40.   과학기술학회마을   DOI
10 Zhan YP, Huang XE, Cao J, et al (2012). Clinical study onsafety and efficacy of $Qinin^{(R)}$ (Cantharidin Sodium) injectioncombined with chemotherapy in treating patients with gastric cancer. Asian Pac J Cancer Prev, 13, 4773-6.   DOI   ScienceOn
11 Zhang WL, Yan TH, Liu B, et al (2011). Systematic reviews and Meta-analysis of Shenmai injection with chemotherapy on treatment of patients with NSCLC. Practical Pharmacy and Clinical Remedies, 2, 95-101.
12 Zhang JH, Zhang G (2012). Clinical observation of Fufang Ban mao capsule for breast cancer patients neo-adjuvantchemotherapy. Chin J Clin Oncol Rehabil, 2-0147-03.
13 Gong P, Huang XE, Chen CY, et al (2012). Comparison oncomplications of peripherally inserted central catheters by ultrasound guide or conventional method in cancer patients. Asian Pac J Cancer Prev, 13, 1873-5.   DOI
14 Deng QQ, Huang XE, Ye LH, et al (2013). Phase II Trial of $Loubo^{(R)}$ (Lobaplatin) and Pemetrexed for Patients with Metastatic Breast Cancer not Responding to Anthracycline or Taxanes. Asian Pac J Cancer Prev, 14, 413-7.   과학기술학회마을   DOI   ScienceOn
15 Bajsa J, Pan Z, Duke SO (2011). Transcriptional responses to cantharidin, a protein phosphatase inhibitor, in Arabidopsis thaliana reveal the involvement of multiple signaltransduction pathways. Physiol Plant, 143, 188-205.   DOI   ScienceOn
16 De Angelis V (2004). Activity, objective response, WHO and RECIST (Response Evaluation Criteria In Solid Tumor)evaluation criteria. Suppl Tumori, 3, 7-9.
17 Gupta D, Lis CG, Grutsch JF (2007). The relationship between cancer-related fatigue and patient satisfaction with quality of life in cancer. J Pain Symptom Manage, 34, 40-7.   DOI
18 Hsieh CH, Huang YC, Tsai TH, Chen YJ (2011). Cantharidin modulates development of human monocyte-deriveddendritic cells. Toxicol In Vitro, 25, 1740-7.   DOI
19 Huang SY, Cao KY (2010). Anti-invasive and anti-metastasis effect of norcantharidin on high-metastatic human breast cancer cell lines. J Trop Med, 9, 1034-45.
20 Huang XE, Wei GL, Huo JG, et al (2013). Intrapleural or intraperitoneal lobaplatin for treatment of patients with malignant pleural effusion or ascites. Asian Pac J Cancer Prev, 14, 2611-4.   과학기술학회마을   DOI   ScienceOn
21 Wang JY, Liu GJ (2009). Eflect of norcantharidin on theexpression of VEGF mRNA in human breast cancer cell lines. Chin Arch Trad Chin Med, 11, 2369-73.
22 Siegel R, Naishadham D, Jemal A(2013). Cancer statistics, 2013. CA Cancer J Clin, 11, 11.30.
23 Verma AK, Prasad SB (2012). Bioactive component, cantharidin from Mylabris cichorii and its antitumor activity against Ehrlich ascites carcinoma. Cell Biol Toxicol, 28, 133-47.   DOI
24 Wang J, Zhang L (2011). The clinical effect of TE chemotherapyregime, with Shenmai injection in the treatment of advancedbreast cancer. J Pharmaceutical Practice, 3, 184-95.
25 Wang Y, Ma KF, Zhang XG, Hu YZ, Shentu JZ (2011). Shenmai Injection in coronary heart disease patients: a systematicreview and Meta-analysis. Chinese J Hospital Pharmacy, 15, 1314-7.
26 Wu XY, Huang XE, You SX, et al (2013). Phase II study of pemetrexed as second or third line combined chemotherapy in patients with colorectal cancer. Asian Pac J Cancer Prev, 14, 2019-22.   과학기술학회마을   DOI   ScienceOn
27 Xia CH, Sun JG, Wang GJ, et al (2010). Herb-drug interactions: in vivo and in vitro effect of shenmai injection, aherbal preparation, on the metabolic activities of hepaticcytochrome P450 3A1/2, 2C6, 1A2 and 2E1 in rats. Plant Medica, 76, 245-50.   DOI
28 Yan HA, Shen K, Huang XE (2013). Clinical study on mannan peptide combined with TP regimen in treating patients with non-small cell lung cancer. Asian Pac J Cancer Prev, 14, 4801-4.   과학기술학회마을   DOI   ScienceOn
29 Shi M, Shen Y (2012). Shenmai Injection for treatment of viral myocarditis: a meta-analysis. Chin Trad Patent Med, 10, 1882-6.