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http://dx.doi.org/10.7314/APJCP.2014.15.12.4781

Treatment of Metastatic Colorectal Cancer With or Without Bevacizumab: Can the Neutrophil/Lymphocyte Ratio Predict the Efficiency of Bevacizumab?  

Dirican, Ahmet (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Varol, Umut (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Kucukzeybek, Yuksel (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Alacacioglu, Ahmet (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Erten, Cigdem (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Somali, Isil (Department of Medical Oncology, Institute of Oncology, Dokuz Eylul University)
Can, Alper (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Demir, Lutfiye (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Bayoglu, Ibrahim Vedat (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Akyol, Murat (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Yildiz, Yasar (Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Koyuncu, Betul (Department of Internal Medicine, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Coban, Eyup (Department of Internal Medicine, Izmir Katip Celebi University Ataturk Training and Research Hospital)
Tarhan, Mustafa Oktay (Department of Medical Oncology, Institute of Oncology, Dokuz Eylul University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.12, 2014 , pp. 4781-4786 More about this Journal
Abstract
Background: The purpose of this study was to analyze the predictive value of neutrophil/lymphocyte ratio (NLR) to better clarify which patient groups will benefit the most from particular treatments like bevacizumab. Materials and Methods: A total of 245 treatment-naive metastatic colorectal cancern (mCRC) patients were retrospectively enrolled and divided into 2 groups: 145 group A patients were treated with chemotherapy in combination with bevacizumab, and 100 group B patients were treated as above without bevacizumab. Results: Group A patients had better median overall survival (OS) and progression-free survival (PFS) (24.0 and 9.0 months) than group B patients (20 and 6.0 months) (p=0.033; p=0.015). In patients with low NLR, OS and PFS were significantly longer in group A patients (27 vs 18 months, p=0.001; 11 vs 7 months, p=0.017). Conclusions: We conclude that NLR, a basal cancer related inflammation marker, is associated with the resistance to bevacizumab-based treatments in mCRC patients.
Keywords
Metastatic colorectal cancer; bevacizumab; neutrophil to lymphocyte ratio; response to therapy;
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Times Cited By KSCI : 8  (Citation Analysis)
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