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http://dx.doi.org/10.7314/APJCP.2014.15.11.4711

Lack of any Prognostic Relationship between Adiponectin Receptor (Adipo R1/R2) Expression for Early/Advanced Stage Gastric Cancer  

Ayyildiz, Talat (Department of Gastroenterology, Faculty of Medicine, Ondokuz Mayis University)
Dolar, Enver (Department of Gastroenterology, Faculty of Medicine, Uludag University)
Ugras, Nesrin (Department of Pathology, Faculty of Medicine, Uludag University)
Dizdar, Oguzhan Sitki (Department of Internal Medicine, Faculty of Medicine, Uludag University)
Adim, Saduman Balaban (Department of Pathology, Faculty of Medicine, Uludag University)
Yerci, Omer (Department of Pathology, Faculty of Medicine, Uludag University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.11, 2014 , pp. 4711-4716 More about this Journal
Abstract
Introduction: Adiponectin (ApN) is a complement C1q-related protein, mainly secreted from adipose tissue, that signals through ApN receptor1 (Adipo-R1) and ApN receptor 2 (Adipo-R2). Low serum ApN concentrations are associated with obesity-related malignancies. However, there are very few studies on any prognostic role of ApN receptors in gastric cancer. Objectives: The aim of this study is to investigate the relationship between AdipoR1/R2 expression and early/advanced stage gastric cancer in terms of clinicopathologic characteristics and survival. Materials and Methods: Eighteen patients with early and 39 with advanced stage gastric cancer who underwent surgical gastric resection were included in this study. Results: Adipo-R1 expression was low in 2 of the 18 patients with early stage gastric cancer (11.1%), while 4 had low Adipo-R2 expression (22.2%). In those with advanced stage gastric cancer, 7 of 39 had low Adipo-R1 expression (17.9%) and 16 had low Adipo-R2 expression (41%). Adipo-R2 expression was significantly higher (p=0.011) in moderately differentiated tumors when compared to well-differentiated tumors. While there was nearly a statistically significant relationship between TNM stage (T, tumor size; N, regional lymph node; M, whether distant metastases exist) and Adipo-R2 expression (p=0.054), there was no relationship between Adipo-R1/-R2 expression with tumor stage and survival. Conclusion: Adipo-R1/-R2 expression has no prognostic significance of in early/advanced stage gastric cancer.
Keywords
Adiponectin; Adipo R1; Adipo R2; gastric carcinoma; survival; prognosis;
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