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http://dx.doi.org/10.7314/APJCP.2014.15.11.4583

Prognostic Significance of Beclin-1 Expression in Colorectal Cancer: a Meta-analysis  

Han, Ye (Department of General Surgery, The First Affiliated Hospital of Soochow University)
Xue, Xiao-Feng (Department of General Surgery, The First Affiliated Hospital of Soochow University)
Shen, Hu-Gang (Department of General Surgery, Kunshan Hospital of Traditional Chinese Medicine)
Guo, Xiao-Bo (Department of Gastrointestinal Surgery, Provincial Hospital Affiliated to Shandong University)
Wang, Xu (Department of General Surgery, The First Affiliated Hospital of Soochow University)
Yuan, Bin (Department of General Surgery, The First Affiliated Hospital of Soochow University)
Guo, Xing-Po (Department of General Surgery, The First Affiliated Hospital of Soochow University)
Kuang, Yu-Ting (Department of General Surgery, The First Affiliated Hospital of Soochow University)
Zhi, Qiao-Ming (Department of General Surgery, The First Affiliated Hospital of Soochow University)
Zhao, Hong (Department of General Surgery, The First Affiliated Hospital of Soochow University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.11, 2014 , pp. 4583-4587 More about this Journal
Abstract
Objective: Beclin-1 has recently been observed as an essential marker of autophagy in several cancers. However, the prognostic role of Beclin-1 in colorectal neoplasia remains controversial. Our study aimed to evaluate the potential association between Beclin-1 expression and the outcome of colorectal cancer patients. Materials and Methods: All related studies were systematically searched in Pubmed, Embase, Springer and Chinese National Knowledge Infrastructure databases (CNKI), and then a meta-analysis was performed to determine the association of Beclin-1 expression with clinical outcomes. Finally, a total of 6 articles were included in our analysis. Results: Our data showed that high Beclin-1 expression in patients with CRC was associated with poor prognosis in terms of tumor distant metastasis (OR=2.090, 95%CI=1.061-4.119, p=0.033) and overall survival (RR=1.422, 95%CI=1.032-1.959, p=0.031). However, we did not found any correlation between Beclin-1 over-expression and tumor differentiation (OR=1.711, 95%CI=0.920-3.183, p=0.090). In addition, there was no evidence of publication bias as suggested by Egger's tests for tumor distant metastasis (p=1.000), differentiation (p=1.000) and OS (p=0.308). Conclusions: Our present meta-analysis indicated that elevated Beclin-1 expression iss associated with tumor metastasis and a poor prognosis in patients with CRC. Beclin-1 might serve as an efficient prognostic indicator in CRC, and could be a new molecular target in CRC therapy.
Keywords
Beclin-1; colorectal cancer; prognosis; meta-analysis;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Chen Z, Li Y, Zhang C, et al (2013). Downregulation of Beclin 1 and impairment of autophagy in a small population of colorectal cancer. Dig Dis Sci, 58, 2887-94.   DOI
2 Ahn CH, Jeong EG, Lee JW, et al (2007). Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS, 115, 1344-9.   DOI
3 Cao Y, Klionsky DJ (2007). Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res, 17, 839-49.   DOI   ScienceOn
4 Geng QR, Xu DZ, He LJ, et al (2012). Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. PLoS One, 7, 45968.   DOI
5 Guo GF, Jiang WQ, Zhang B, et al (2011). Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer. World J Gastroenterol, 17, 4779-86.   DOI
6 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
7 Kekelidze M, D'Errico L, Pansini M, Tyndall A, Hohmann J (2013). Colorectal cancer: current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation. World J Gastroenterol, 19, 8502-14.   DOI
8 Khiewkhern S, Promthet S, Sukprasert A, Eunhpinitpong W, Bradshaw P (2013). Effectiveness of aromatherapy with light thai massage for cellular immunity improvement in colorectal cancer patients receiving chemotherapy. Asian Pac J Cancer Prev, 14, 3903-7.   과학기술학회마을   DOI
9 Kim HS, Lee SH, Do SI, et al (2011). Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma. Pathol Res Pract, 207, 247-52.   DOI
10 Koukourakis MI, Giatromanolaki A, Sivridis E, et al (2010). Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia. Br J Cancer, 103, 1209-14.   DOI
11 Klionsky DJ, Emr SD (2000). Autophagy as a regulated pathway of cellular degradation. Science, 290, 1717-21.   DOI   ScienceOn
12 Koneri K, Goi T, Yamaguchi A (2003) Analysis of cell cycle inhibition by novel tumor suppressor gene Beclin 1 in human colon cancer cells. Nihon Rinsho, 61, 247-51.
13 Koneri K, Goi T, Hirono Y, Katayama K, Yamaguchi A (2007). Beclin 1 gene inhibits tumor growth in colon cancer cell lines. Anticancer Res, 27, 1453-7.
14 Li BX, Li CY, Peng RQ, et al (2009). The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy, 5, 303-6.   DOI
15 Parmar MK, Torri V, Stewart L (1998). Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med, 17, 2815-34.   DOI
16 Maiuri MC, Tasdemir E, Criollo A, et al (2009). Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ, 16, 87-93.   DOI   ScienceOn
17 Miracco C, Cosci E, Oliveri G, et al (2007). Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol, 30, 429-36.
18 Myung Park J, Huang S, Wu TT, Foster NR, Sinicrope FA (2013). Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy. Cancer Biol Ther, 14, 100-7.   DOI
19 Xia P, Wang JJ, Zhao BB, Song CL (2013). The role of beclin-1 expression in patients with gastric cancer: a meta-analysis. Tumour Biol, 34, 3303-7.   DOI
20 Song H, Xia SL, Liao C, et al (2004). Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma. World J Gastroenterol, 10, 509-13.
21 Sui YQ, Feng YZ (2012). Expreesion and clinical significance of autophage-ralated genes LC3, Beclin-1 and apoptosis-related genes p53, BCL-2 in colorectal carcinoma. J Clin Exp pathol, 28, 282-6.
22 Tong GX, Chai J, Cheng J, et al (2014). Diagnostic value of rectal bleeding in predicting colorectal cancer: a systematic review. Asian Pac J Cancer Prev, 15, 1015-21.   과학기술학회마을   DOI   ScienceOn
23 Zois CE, Koukourakis MI (2009). Radiation-induced autophagy in normal and cancer cells: towards novel cytoprotection and radio-sensitization policies? Autophagy, 5, 442-50.   DOI   ScienceOn
24 Zafar SY, Malin JL, Grambow SC, et al (2013). Chemotherapy use and patient treatment preferences in advanced colorectal cancer: a prospective cohort study. Cancer, 119, 854-62.   DOI
25 Zeng X, Overmeyer JH, Maltese WA (2006) Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J Cell Sci, 119, 259-70.   DOI   ScienceOn
26 Zhang HQ, He B, Fang N, et al (2013). Autophagy inhibition sensitizes cisplatin cytotoxicity in human gastric cancer cell line SGC7901. Asian Pac J Cancer Prev, 14, 4685-8.   과학기술학회마을   DOI
27 Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008). Autophagy fights disease through cellular self-digestion. Nature, 451, 1069-75.   DOI   ScienceOn