p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid |
Liu, Jia
(Institutes of Oceanology, Chinese Academy of Sciences)
Wu, Ning (Institutes of Oceanology, Chinese Academy of Sciences) Ma, Lei-Na (Department of Molecular Biology, School of Medicine and Pharmacy, Ocean University of China) Zhong, Jia-Teng (Department of Pathophysiology, Norman Bethune College of Medicine, Jilin University) Liu, Ge (Institutes of Oceanology, Chinese Academy of Sciences) Zheng, Lan-Hong (Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences) Lin, Xiu-Kun (Institutes of Oceanology, Chinese Academy of Sciences) |
1 | Volynets GP, Chekanov MO, Synyugin AR, et al (2011). Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J Med Chem, 54, 2680-6. DOI |
2 | Wang X, Bai H, Zhang X, et al (2013). Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis. Carcinogenesis, |
3 | Wei J, Liu M, Liu H, et al (2012). Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells. J Appl Toxicol, 33, 756-65. |
4 | Yan SL, Huang CY, Wu ST, Yin MC (2010). Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines. Toxicol In Vitro, 24, 842-8. DOI ScienceOn |
5 | Yu JS, Kim AK (2012). Platycodin D induces reactive oxygen species-mediated apoptosis signal-regulating kinase 1 activation and endoplasmic reticulum stress response in human breast cancer cells. J Med Food, 15, 691-9. DOI |
6 | Zhang P, Li H, Chen D, et al (2007). Oleanolic acid induces apoptosis in human leukemia cells through caspase activation and poly(ADP-ribose) polymerase cleavage. Acta Biochim Biophys Sin, 39, 803-9. DOI ScienceOn |
7 | Zhou R, Zhang Z, Zhao L, et al (2011). Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. J Orthop Res, 29, 846-52. DOI ScienceOn |
8 | Chen F (2012). JNK-induced apoptosis, compensatory growth, and cancer stem cells. Cancer Res, 72, 379-86. DOI |
9 | Chakravarti B, Maurya R, Siddiqui JA, et al (2012). In vitro anti-breast cancer activity of ethanolic extract of Wrightia tomentosa: role of pro-apoptotic effects of oleanolic acid and urosolic acid. J Ethnopharmacol, 142, 72-9. DOI |
10 | Cai B, Chang SH, Becker EB, et al (2006). p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem, 281, 25215-22. DOI ScienceOn |
11 | Cuadrado A, Nebreda AR (2010). Mechanisms and functions of p38 MAPK signalling. Biochem J, 429, 403-17. DOI ScienceOn |
12 | da Conceicao AO, de Oliveira FF, de Oliveira RA, et al (2012). Lantana macrophylla Schauer (Verbenaceae) ethanolic extract induces activation of ERK1/2 and p38 MAPKs pathway and Ca2+ imbalance in human trophoblasts derived cell lines. Food Chem Toxicol, 50, 1001-12. DOI |
13 | Gu G, Barone I, Gelsomino L, et al (2012). Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERalpha/Sp1-mediated p53 activation. J Cell Physiol, 227, 3363-72. DOI |
14 | Feng J, Zhang P, Chen X, He G (2011a). PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells. J Cell Biochem, 112, 1524-31. DOI ScienceOn |
15 | Feng L, Au-Yeung W, Xu YH, et al (2011b). Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression. Asian Pac J Cancer Prev, 12, 403-8. |
16 | Kim BJ, Ryu SW, Song BJ (2006). JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem, 281, 21256-65. DOI ScienceOn |
17 | George VC, Kumar DR, Suresh PK, Kumar RA (2012). Apoptosis-induced cell death due to oleanolic acid in HaCaT keratinocyte cells--a proof-of-principle approach for chemopreventive drug development. Asian Pac J Cancer Prev, 13, 2015-20. 과학기술학회마을 DOI ScienceOn |
18 | Hayakawa R, Hayakawa T, Takeda K, Ichijo H (2012). Therapeutic targets in the ASK1-dependent stress signaling pathways. Proc Jpn Acad Ser B Phys Biol Sci, 88, 434-53. DOI |
19 | Juan ME, Wenzel U, Ruiz-Gutierrez V, et al (2006). Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells. J Nutr, 136, 2553-7. |
20 | Liby KT, Yore MM, Sporn MB (2007). Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat Rev Cancer, 7, 357-69. DOI ScienceOn |
21 | Lucio KA, Rocha Gda G, Moncao-Ribeiro LC, et al (2011). Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. PLoS One, 6, 28596. DOI |
22 | Pan J, Chang Q, Wang X, et al (2010). Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Chem Res Toxicol, 23, 568-77. DOI ScienceOn |
23 | Markou T, Dowling AA, Kelly T, Lazou A (2009). Regulation of Bcl-2 phosphorylation in response to oxidative stress in cardiac myocytes. Free Radic Res, 43, 809-16. DOI |
24 | Pratheeshkumar P, Kuttan G (2011). Oleanolic acid induces apoptosis by modulating p53, Bax, Bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in B16F. J Environ Pathol Toxicol Oncol, 30, 21-31. DOI |
25 | Martin R, Carvalho-Tavares J, Ibeas E, et al (2007). Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation. Cancer Res, 67, 3741-51. DOI |
26 | Martinez-Gonzalez J, Rodriguez-Rodriguez R, Gonzalez-Diez M, et al (2008). Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism. J Nutr, 138, 443-8. |
27 | Petronelli A, Pannitteri G, Testa U (2009). Triterpenoids as new promising anticancer drugs. Anticancer Drugs, 20, 880-92. DOI |
28 | Rosini P, De Chiara G, Lucibello M, et al (2000). NGF withdrawal induces apoptosis in CESS B cell line through p38 MAPK activation and Bcl-2 phosphorylation. Biochem Biophys Res Commun, 278, 753-9. DOI |
29 | Shyu MH, Kao TC, Yen GC (2010). Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP. J Agric Food Chem, 58, 6110-8. DOI ScienceOn |
30 | Wang X, Ye XL, Liu R, et al (2010). Antioxidant activities of oleanolic acid in vitro: possible role of Nrf2 and MAP kinases. Chem Biol Interact, 184, 328-37. DOI ScienceOn |
31 | Struh CM, Jager S, Schempp CM, et al (2012). A novel triterpene extract from mistletoe induces rapid apoptosis in murine B16.F10 melanoma cells. Phytother Res, 26, 1507-12. |
32 | Capano M, Crompton M (2006). Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases. Biochem J, 395, 57-64. DOI |
33 | Pollier J, Goossens A (2012). Oleanolic acid. Phytochemistry, 77, 10-5. DOI ScienceOn |