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http://dx.doi.org/10.7314/APJCP.2013.14.9.5449

Combined Germline Variations of Thrombophilic Genes Promote Genesis of Lung Cancer  

Ozen, Filiz (Department of Medical Genetics, Faculty of Medicine, Cumhuriyet University)
Polat, Fikriye (Department of Elementary Sciences Education, Faculty of Education, Kocaeli University)
Arslan, Sulhattin (Department of Cheast, Faculty of Medicine, Cumhuriyet University)
Ozdemir, Ozturk (Department of Medical Genetics, Faculty of Medicine, Cumhuriyet University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.9, 2013 , pp. 5449-5454 More about this Journal
Abstract
Background: A large variety of familiar and non-familiar lung carcinomas (LC) are caused by long term exposure to chemical carcinogens that are present in tobacco smoke. We aimed to investigate the prevalence of 5 thrombophilic germ-line mutations in patients with lung carcinomas. Materials and Methods:A total of 52 LC patients and 212 healthy controls from same population were analyzed for FV Leiden, factor V H1299R (R2), PAI-1, MTHFR C677T, MTHFR A1298C, ACE I/D, and Apo E genes and compared. Results: Overall, heterozygous and/or homozygous point mutations in FV Leiden Apo E2, PAI-1 and MTHFR C677T genes were associated with LC in the current cohort. There was no meaningful association between LC and ACE I/D gene markers. Conclusions: The current results showed that LC is related to combined thrombophilic gene mutations and individuals with homozygosity of 4G in PAI-1 and MTHFR C677T genes and heterozygosity of FV Leiden, Apo E4 genes have a germ-line risk for LC tumorigenesis.
Keywords
A case control study; combined thrombophilic genes; lung cancer; germ-line variations;
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