Lgr4 Promotes Glioma Cell Proliferation through Activation of Wnt Signaling |
Yu, Chun-Yong
(Department of Neurosurgery, Shengjing Hospital, China Medical University)
Liang, Guo-Biao (Department of Neurosurgery, Shengyang Northern Hospital) Du, Peng (Department of Neurosurgery, Shengjing Hospital, China Medical University) Liu, Yun-Hui (Department of Neurosurgery, Shengjing Hospital, China Medical University) |
1 | Bondy ML, Scheurer ME, Malmer B, et al (2008). Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer, 8, 1953-68. |
2 | Brewer C, Yeager N, Di Cristofano A (2007). Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT. Cancer Res, 67, 8002-6. DOI ScienceOn |
3 | Casas-Selves M, Kim J, Zhang Z, et al (2012). Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Res, 72, 4154-64. DOI |
4 | Chartier NT, Oddou CI, Laine MG, et al (2007). Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)-dependent cell growth control: a new role for p120ctn in cancer. Cancer Res, 67, 9781-90. DOI ScienceOn |
5 | de Lau W, Barker N, Low TY, et al (2011). Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature, 476, 293-7. DOI ScienceOn |
6 | Deng J, Miller SA, Wang HY, et al (2002). beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell, 2, 323-34. DOI ScienceOn |
7 | Fodde R, Smits R, Clevers H (2001). APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer, 1, 55-67. DOI ScienceOn |
8 | Gao Y, Kitagawa K, Hiramatsu Y, et al (2006). Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res, 66, 11623-31. DOI ScienceOn |
9 | Gigineishvili D, Shengelia N, Shalashvili G, et al (2013). Primary brain tumour epidemiology in Georgia: first-year results of a population-based study. J Neurooncol, 8, 241-6. |
10 | Glinka A, Dolde C, Kirsch N, et al (2011). LGR4 and LGR5 are R-spondin receptors mediating Wnt/-catenin and Wnt/PCP signalling. EMBO Rep, 12, 1055-61. DOI ScienceOn |
11 | Kudo M, Chen T, Nakabayashi K, Hsu SY, Hsueh AJ (2000). The nematode leucine-rich repeat-containing, G protein-coupled receptor (LGR) protein homologous to vertebrate gonadotropin and thyrotropin receptors is constitutively active in mammalian cells. Mol Endocrinol, 14, 272-84. DOI ScienceOn |
12 | Lagerstrom MC, Schioth HB (2008). Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov, 7, 339-57. DOI ScienceOn |
13 | Lappano R, Maggiolini M (2011). G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov, 10, 47-60. DOI ScienceOn |
14 | Li XY, Lu Y, Sun HY, et al (2010). G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract. Development, 137, 151-7. DOI ScienceOn |
15 | Loh ED, Broussard SR, Kolakowski LF (2001). Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor. Biochem Biophys Res Commun, 282, 757-64. DOI ScienceOn |
16 | Luo J, Zhou W, Zhou X, et al (2009). Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development, 136, 2747-56. DOI ScienceOn |
17 | Mazerbourg S, Bouley DM, Sudo S, et al (2004). Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol, 18, 2241-54. DOI ScienceOn |
18 | Mohri Y, Kato S, Umezawa A, Okuyama R, Nishimori K (2008). Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4. Dev Dyn, 237, 2235-42. DOI ScienceOn |
19 | Moon RT, Kohn AD, De Ferrari GV, Kaykas A (2004). WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet, 5, 691-701. DOI ScienceOn |
20 | Niehrs C (2012). The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol, 13, 767-79. DOI ScienceOn |
21 | Angers S, Moon RT (2009). Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol, 10, 468-77. |
22 | Obermajer N, Muthuswamy R, Odunsi K, Edwards RP, Kalinski P (2011). PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment. Cancer Res, 71, 7463-70. DOI ScienceOn |
23 | Ostrom QT, Barnholtz-Sloan JS (2011). Current state of our knowledge on brain tumor epidemiology. Curr Neurol Neurosci Rep, 8, 329-35. |
24 | Panza A, Pazienza V, Ripoli M, et al (2013). Interplay between SOX9, b-catenin and PPARγ activation in colorectal cancer. Biochim Biophys Acta, 1833, 1853-65. DOI ScienceOn |
25 | Qian Y, Liu S, Guan Y, et al (2013). Lgr4-mediated Wnt/b-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development, 140, 1751-61. DOI ScienceOn |
26 | Sengupta R, Dubuc A, Ward S, et al (2012). CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Res, 72, 122-32. DOI |
27 | Stevens RC, Cherezov V, Katritch V, et al (2013). The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov, 12, 25-34. |
28 | Xie D, Yin D, Tong X, et al (2004). Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways. Cancer Res, 64, 1987-96. DOI ScienceOn |
29 | Xing M, Usadel H, Cohen Y, et al (2003). Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing. Cancer Res, 63, 2316-21. |
30 | Zurawel RH, Chiappa SA, Allen C, Raffel C (1998). Sporadic medulloblastomas contain oncogenic beta-catenin mutations. Cancer Res, 58, 896-9. |
31 | Baryawno N, Sveinbjornsson B, Eksborg S, et al (2010). Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth. Cancer Res, 70, 266-76. DOI |
32 | Angers S, Moon RT (2009). Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol, 10, 468-77. |