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http://dx.doi.org/10.7314/APJCP.2013.14.8.4743

Prevalence of and Factors Associated with Osteoporosis among Korean Cancer Survivors: A Cross-Sectional Analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys  

Choi, Kyung-Hyun (Department of Family Medicine, Dong-A University College of Medicine)
Park, Sang Min (Department of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine)
Park, Joo-Sung (Department of Family Medicine, Dong-A University College of Medicine)
Park, Jae-Hyun (Department of Social and Preventive Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine)
Kim, Kyae Hyung (Department of Family Medicine, Seoul National University Hospital)
Kim, Myung-Ju (Department of Health Sciences, Graduate School of Kosin University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.8, 2013 , pp. 4743-4750 More about this Journal
Abstract
Background: Identifying and managing osteoporosis among cancer survivors is an important issue, yet little is known about the bone health of cancer survivors in Korea. This study was designed to measure the prevalence of osteoporosis and to assess related factors among Korean cancer survivors. Materials and Methods: This study was designed as a cross-sectional analysis. Data were obtained from dual energy X-ray absorptiometry measurement of the lumbar vertebrae and femoral neck, and from standardized questionnaires among 556 cancer survivors and 17,623 non-cancer controls who participated in the Fourth and Fifth Korea National Health and Nutrition Examination Surveys (2008-2011). We calculated adjusted proportions of osteoporosis in non-cancer controls vs. cancer survivors, and we performed multivariate logistic regression analysis. Results: The prevalence of osteoporosis among cancer survivors was significant higher than that of the non-cancer controls after adjusting for related factors. Furthermore, osteoporosis among cancer survivors was higher in elderly subjects (60-69 years : adjusted odds ratio (aOR) 3.04, 95% CI : 1.16-8.00, ${\geq}70$ years : aOR 6.60, 95% CI 2.20-19.79), in female cancer survivors (aOR: 7.03, 95% CI: 1.88-26.28), and in a group with lower monthly income (aOR: 3.38, 95% CI: 1.31-8.71). In male cancer survivors, underweight and lower calcium intake were risk factors. Conclusions: These data suggest that the osteoporosis among cancer survivors varies according to non-oncologic and oncologic factors. Effective screening should be applied, and a sufficient and comprehensive management should be matched to individual cancer survivors early after cancer treatment.
Keywords
Osteoporosis; prevalence; risk factor; cancer survivors; Korea;
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1 Allali F, Rostom S, Bennani L, et al (2010). Educational level and osteoporosis risk in postmenopausal Moroccan women: a classification tree analysis. Clin Rheumatol, 29, 1269-75.   DOI
2 Brennan RM, Wactawski-Wende J, Crespo CJ, et al (2004). Factors associated with treatment initiation after osteoporosis screening. Am J Epidemiol, 160, 475-83.   DOI   ScienceOn
3 Brown SA, Guise TA (2009). Cancer treatment-related bone disease. Crit Rev Eukaryot Gene Expr, 19, 47-60.   DOI
4 Camacho PM, Dayal AS, Diaz JL, et al (2008). Prevalence of secondary causes of bone loss among breast cancer patients with osteopenia and osteoporosis. J Clin Oncol, 26, 5380-5.   DOI   ScienceOn
5 National Cancer Information Center (2011). Cancer incidence[Online], Available from: http://www.cancer.go.kr/ncic/cics_f/01/011/index.html. [2012, October 1].
6 Chen Z, Maricic M, Pettinger M, et al (2005). Osteoporosis and rate of bone loss among postmenopausal survivors of breast cancer. Cancer, 104, 1520-30.   DOI   ScienceOn
7 Choi HJ, YH SC(2010). Osteoporosis Reimbursement Policy: United States of America, Europe and Korea. Korean J Bone Metabolism, 17, 7-12.
8 Christenson ES, Jiang X, Kagan R, et al (2012). Osteoporosis management in post-menopausal women. Minerva Ginecol, 64, 181-94
9 Ding H, Yang L, Du W, et al (2013). Bisphosphonates for Osteoporosis in Nonmetastatic Prostate Cancer Patients Receiving Androgen-deprivation Therapy: A Systematic Review and Meta-analysis. Asian Pac J Cancer Prev, 14, 3337-43.   DOI   ScienceOn
10 Ehrsson YT, Langius-Eklof A, Laurell G (2012). Nutritional surveillance and weight loss in head and neck cancer patients. Support Care Cancer, 20, 757-65   DOI
11 Felson DT, Zhang Y, Hannan MT, et al (1993). Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res, 8, 567-73.
12 Filipponi P, Gregorio F, Cristallini S, et al (1990). Partial gastrectomy and mineral metabolism: effects on gastrin-calcitonin release. Bone Miner, 11, 199-208.   DOI   ScienceOn
13 Fontanges E, Fontana A, Delmas P (2004). Osteoporosis and breast cancer. Joint Bone Spine, 71, 102-10.   DOI   ScienceOn
14 Ganry O, Baudoin C, Fardellone P (2000). Effect of alcohol intake on bone mineral density in elderly women: The EPIDOS Study. Epidemiologie de l’Osteoporose. Am J Epidemiol, 151, 773-80.   DOI   ScienceOn
15 Goodwin PJ, Ennis M, Pritchard KI, et al (1999). Risk of menopause during the first year after breast cancer diagnosis. J Clin Oncol, 17, 2365-70.
16 Gralow JR, Biermann JS, Farooki A, et al (2009). NCCN Task Force Report: Bone Health in Cancer Care. J Natl Compr Canc Netw, 7, 33-5.
17 Grossmann M, Hamilton EJ, Gilfillan C, et al (2011). Bone and metabolic health in patients with non-metastatic prostate cancer who are receiving androgen deprivation therapy. Med J Aust, 194, 301-6.
18 Guise TA(2006). Bone Loss and Fracture Risk Associated with Cancer Therapy. The Oncologist, 11, 1121-31.   DOI   ScienceOn
19 Jung KW, Park S, Kong HJ, et al (2011). Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2008. Cancer Res Treat, 43, 1.   DOI   ScienceOn
20 Khan MN, Khan AA (2008). Cancer treatment-related bone loss: a review and synthesis of the literature. Curr Oncol, 15, 30-40.   DOI
21 Lim JS, Lee JI(2011). Prevalence, Pathophysiology, Screening and Management of Osteoporosis in Gastric Cancer Patients. J Gastric Cancer, 11, 7-15.   DOI   ScienceOn
22 Kim KH, Lee K, Ko YJ, et al (2012). Prevalence, awareness, and treatment of osteoporosis among Korean women: The Fourth Korea National Health and Nutrition Examination Survey. Bone, 50, 1039-47.   DOI   ScienceOn
23 Lewiecki EM, Gordon CM, Baim S, et al (2008). International Society for Clinical Densitometry 2007 Adult and Pediatric Official Positions. Bone, 43, 1115-21.   DOI   ScienceOn
24 Lim JS, Kim SB, Bang HY, et al (2007). High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy. World J Gastroenterol, 13, 6492-7.   DOI   ScienceOn
25 Malcolm JB, Derweesh IH, Kincade MC, et al (2007). Osteoporosis and fractures after androgen deprivation initiation for prostate cancer. Can J Urol, 14, 3551-9.
26 McKean H, Looker S, Hartmann LC, et al (2008). Are cancer survivors/patients knowledgeable about osteoporosis? Results from a survey of 285 chemotherapy-treated cancer patients and their companions. J Nutr Educ Behav, 40, 144-8.   DOI   ScienceOn
27 Meadows ES, Mitchell BD, Bolge SC, et al (2012). Factors associated with treatment of women with osteoporosis or osteopenia from a national survey. BMC Womens Hlth, 12, 1-9.   DOI   ScienceOn
28 Melton LJ 3rd, Khosla S, Malkasian GD, et al (2003). Fracture risk after bilateral oophorectomy in elderly women. J Bone Miner Res, 18, 900-5.   DOI   ScienceOn
29 Miro C, Orecchia R (2002). Osteoporosis, risk of radiation-induced fracture and quality of life. Lancet, 360, 1429.   DOI   ScienceOn
30 Moon SH, Lee DT, Son Y (2013). Adherence to Health-Related Lifestyle Behavior Recommendations and Association with Quality of Life among Cancer Survivors and Age-Matched Controls in Korea. Asian Pac J Cancer Prev, 14, 2949-54.   DOI   ScienceOn
31 Murray TM (1996). Prevention and management of osteoporosis: consensus statements from the Scientific Advisory Board of the Osteoporosis Society of Canada. 4. Calcium nutrition and osteoporosis. CMAJ, 155, 935-9.
32 Nordin BE, Need AG, Steurer T, et al (1998). Nutrition, osteoporosis, and aging. Ann N Y Acad Sci, 854, 336-51.   DOI
33 Olmos Martinez JM, Gonzalez Macias J(2007). Osteoporosis in cancer survivors. Med Clin (Barc), 129, 669-76.   DOI
34 Orimo H, Hayashi Y, Fukunaga M, et al (2001). Diagnostic criteria for primary osteoporosis: year 2000 revision. J Bone Miner Metab, 19, 331-7.   DOI   ScienceOn
35 Ouattara M, D’Journo XB, Loundou A, et al (2012). Body mass index kinetics and risk factors of malnutrition one year after radical oesophagectomy for cancer. Eur J Cardiothorac Surg, 41, 1088-93   DOI   ScienceOn
36 Peterlik M, Boonen S, Cross HS, et al (2009). Vitamin D and calcium insufficiency-related chronic diseases: an emerging world-wide public health problem. Int J Environ Res Public Health, 6, 2585-607   DOI
37 Peterlik M, Kallay E, Cross HS, et al (2013). Calcium nutrition and extracellular calcium sensing: relevance for the pathogenesis of osteoporosis, cancer and cardiovascular diseases. Nutrients, 5, 302-27   DOI
38 Korea National Health & Nutrition Examniation Survey (2012).Mannual for Examination Survey, Available from: http://knhanes.cdc.go.kr/knhanes/index.do. [2012, October 1]
39 Reuss-Borst M, Hartmann U, Scheede C(2011). Prevalence of osteoporosis among cancer patients in Germany. Osteoporosis Int, 23, 1437-44.
40 Ryan CW, Huo D, Stallings JW, et al (2007). Lifestyle factors and duration of androgen deprivation affect bone mineral density of patients with prostate cancer during first year of therapy. Urol, 70, 122-6.
41 Saad F, Adachi JD, Brown JP, et al (2008). Cancer treatment-induced bone loss in breast and prostate cancer. J Clin Oncol, 26, 5465-76.   DOI   ScienceOn
42 Shapiro CL, Manola J, Leboff M (2001). Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer. J Clin Oncol, 19, 3306-11.
43 Shin CS, Choi HJ, Kim MJ, et al (2010). Prevalence and risk factors of osteoporosis in Korea: a community-based cohort study with lumbar spine and hip bone mineral density. Bone, 47, 378-87.   DOI   ScienceOn
44 Siegel R, Naishadham D, Jemal A, et al (2012). Cancer statistics, 2012. CA Cancer J Clin, 62, 10-29.   DOI   ScienceOn
45 Smith MR(2002). Osteoporosis and other adverse body composition changes during androgen deprivation therapy for prostate cancer. Cancer Metastasis Rev, 21, 159-66.   DOI   ScienceOn
46 Stava CJ, Jimenez C, Hu MI(2009). Skeletal sequelae of cancer and cancer treatment. J Cancer Surviv, 3, 75-88.   DOI   ScienceOn
47 van Londen GJ, Taxel P, Van Poznak C(2008). Cancer therapy and osteoporosis: approach to evaluation and management. Semin Oncol, 35, 643-51.   DOI   ScienceOn
48 VanderWalde A, Hurria A(2011). Aging and osteoporosis in breast and prostate cancer. CA Cancer J Clin, 61, 139-56   DOI