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http://dx.doi.org/10.7314/APJCP.2013.14.8.4671

Variation of Blood T Lymphocyte Subgroups in Patients with Non- small Cell Lung Cancer  

Wang, Wen-Jing (Department of Infectious Diseases, Nanjing First Hospital, Nanjing Medical University)
Tao, Zhen (Department of Infectious Diseases, Nanjing First Hospital, Nanjing Medical University)
Gu, Wei (Department of Respiration, Nanjing First Hospital, Nanjing Medical University)
Sun, Li-Hua (Department of Respiration, Nanjing First Hospital, Nanjing Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.8, 2013 , pp. 4671-4673 More about this Journal
Abstract
Objectives: To study variation in T lymphocyte subgoups and its clinical significance in non-small cell lung cancer (NSCLC). Methods: Levels of CD3+, CD4+, CD8+, CD4+/CD8+, NK and Treg cells in peripheral blood of NSCLC cases and healthy adults were determined by flow cytometry. Results: CD3+, CD4+ and CD4+/CD8+ ratio and NK cells in NSCLCs were decreased significantly in comparison with the control group (P < 0.01), and decreased with increase in the clinical stage of NSCLC, while CD8+ cells demonstrated no significant change (P > 0.05). Treg cells were significantly more frequent than in the control group (P < 0.01), and increased with the clinical stage of NSCLC. Conclusion: The cellular immune function of the NSCLC patients is lowered. It is important to detect change of T lymphocyte subgroups by flow cytometry for the diagnosis, treatment and prognostic assessment of NSCLC patients.
Keywords
Non-small cell lung cancer; lymphocyte subset; flow cytometry; cellular immune;
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