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http://dx.doi.org/10.7314/APJCP.2013.14.8.4501

Significance of Caveolin-1 Regulators in Pancreatic Cancer  

Chen, Tao (Department of Pancreas and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center)
Liu, Liang (Department of Pancreas and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center)
Xu, Hua-Xiang (Department of Pancreas and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center)
Wang, Wen-Quan (Department of Pancreas and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center)
Wu, Chun-Tao (Department of Pancreas and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center)
Yao, Wan-Tong (Department of Pancreas and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center)
Yu, Xian-Jun (Department of Pancreas and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.8, 2013 , pp. 4501-4507 More about this Journal
Abstract
Caveolin-1 is a scaffold protein on the cell membrane. As the main component of caveolae, caveolin-1 is involved in many biological processes that include substance uptake and transmembrane signaling. Many of these processes and thus caveolin-1 contribute to cell transformation, tumorigenesis, and metastasis. Of particular interest are the dual rolesof tumor suppressor and oncogene that caveolin-1 appear to play in different malignancies, including pancreatic cancer. Therefore, analyzing caveolin-1 regulators and understanding their mechanisms of actionis key to identifying novel diagnostic and therapeutic tools for pancreatic cancer. This review details the mechanisms of action of caveolin-1 regulators and the potential significance for pancreatic cancer treatment.
Keywords
Caveolae; caveolin-1; pancreatic cancer; regulatory factor; significance;
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