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http://dx.doi.org/10.7314/APJCP.2013.14.7.4301

B-cell Lymphoma 2 rs17757541 C>G Polymorphism was Associated with an Increased Risk of Gastric Cardiac Adenocarcinoma in a Chinese Population  

Li, Qiong (Department of Plastic Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology)
Yin, Jun (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
Wang, Xu (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
Wang, Li-Ming (Cancer Institute, Department of Chemotherapy, People's Hospital Affiliated to Jiangsu University)
Shi, Yi-Jun (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
Zheng, Liang (Department of Cardiothoracic Surgery, The First People's Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University)
Tang, Wei-Feng (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
Ding, Guo-Wen (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
Liu, Chao (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
Liu, Rui-Ping (Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital)
Gu, Hai-Yong (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
Sun, Jia-Ming (Department of Plastic Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology)
Chen, Suo-Cheng (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.7, 2013 , pp. 4301-4306 More about this Journal
Abstract
Aim: Apoptosis has been considered as a fundamental component in cancer pathogenesis, and related genetic factors might play an important role in gastric cardiac adenocarcinoma (GCA) genesis. Methods: We conducted a hospital based case.control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs): BCL2 rs17757541 C>G, BCL2 rs12454712 T>C, FAS rs2234767 G>A, FASL/FASLG rs763110 C>T, ERBB2 rs1136201 A>G and VEGFR2/KDR rs11941492 C>T on the development of GCA. A total of 243 GCA cases and 476 controls were recruited for the study and genotypes were determined using a custom-by-design 48-Plex SNPscan$^{TM}$ Kit. Results: The BCL2 rs17757541 C>G polymorphism was associated with increased risk of GCA. However, there was no significant associations with the other five SNPs. Stratified analyses indicated a significantly increased risk of GCA associated with the BCL2 rs17757541 C>G polymorphism among males, older patients and those with a history of smoking or drinking. Conclusion: These findings indicated that the functional polymorphism BCL2 rs17757541 C>G might contribute to GCA susceptibility. However, our results were limited by small sample size. Future larger studies are required to confirm our current findings.
Keywords
BCL2; polymorphisms; gastric cardiac adenocarcinoma; molecular epidemiology;
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