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http://dx.doi.org/10.7314/APJCP.2013.14.7.4199

Relationships between Skin Cancers and Blood Groups - Link between Non-melanomas and ABO/Rh Factors  

Cihan, Yasemin Benderli (Department of Radiation Oncology, Kayseri Education and Research Hospital)
Baykan, Halit (Department of Plastic Surgery, Kayseri Education and Research Hospital)
Kavuncuoglu, Erhan (Department of Computer Technologies, Cumhuriyet University Gemerek Vocation School)
Mutlu, Hasan (Medical Oncology, Kayseri Acıbadem Hospital)
Kucukoglu, Mehmet Burhan (Erciyes University Medicine School)
Ozyurt, Kemal (Department of Dermatology, Kayseri Education and Research Hospital)
Oguz, Arzu (Department of Medical Oncology, Kayseri Education and Research Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.7, 2013 , pp. 4199-4203 More about this Journal
Abstract
Background: This investigation focused on possible relationships between skin cancers and ABO/Rh blood groups. Materials and Methods: Between January 2005 and December 2012, medical data of 255 patients with skin cancers who were admitted to Kayseri Training and Research Hospital, Radiation Oncology and Plastic Surgery Outpatient Clinics were retrospectively analyzed. Blood groups of these patients were recorded. The control group consisted of 25701 healthy volunteers who were admitted to Kayseri Training and Research Hospital, Blood Donation Center between January 2010 and December 2011. The distribution of the blood groups of the patients with skin cancers was compared to the distribution of ABO/Rh blood groups of healthy controls. The association of the histopathological subtypes of skin cancer with the blood groups was also investigated. Results: Of the patients, 50.2% had A type, 26.3% had O type, 16.1% had B type, and 7.5% had AB blood group with a positive Rh (+) in 77.3%. Of the controls, 44.3% had A type, 31.5% had 0 type, 16.1% had B type, and 8.1% had AB blood group with a positive Rh (+) in 87.8%. There was a statistically significant difference in the distribution of blood groups and Rh factors (A Rh (-) and 0 Rh positive) between the patients and controls. A total of 36.8% and 20.4% of the patients with basal cell carcinoma (BCC) had A Rh (+) and B Rh (+), respectively, while 39.2% and 27.6% of the controls had A Rh (+) and B Rh (+), respectively. A significant relationship was observed between the patients with BCC and controls in terms of A Rh (-) (p=0.001). Conclusion: Our study results demonstrated that there is a significant relationship between non-melanoma skin cancer and ABO/Rh factors.
Keywords
ABO blood group; skin cancer; Rh factor; basal cell carcinoma; squamous cell carcinoma;
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1 Adamian RT (2005). Blood-type and rhesus distribution in Armenian women with endometrial carcinoma. Vopr Onkol, 51, 575-6.
2 Aird I, Bentall HH, Roberts JA (1953). A relationship between cancer of stomach and the ABO blood groups. Brit Med J, 1, 799-801.   DOI
3 Alavi S, Ashraf H, Rashidi A, et al (2006). Distribution of ABO blood groups in childhood acute leukemia. Pediatr Hematol Oncol, 23, 611-7.   DOI   ScienceOn
4 Armstrong BK, Kricker A (1995). Skin cancer. Dermatol Clin, 13, 583-94.
5 Ben Q, Wang K, Yuan Y, et al (2011). Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese patients: a case-control study. Int J Cancer, 128, 1179-86.   DOI   ScienceOn
6 Cerny T, Fey MF, Oppliger R, et al (2006). Prevalence of the rhesus-negative phenotype in caucasian patients with small-cell lung cancer (SCLC). Int J Cancer, 52, 504-6.
7 Coon JS, Weinstein RS (1986). Blood group-related antigens as markers of malignant potential and heterogeneity in human carcinomas. Hum Pathol, 17, 1089-106.   DOI   ScienceOn
8 Edgren G, Hjalgrim H, Rostgaard K, et al (2010). Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol, 172, 1280-5   DOI   ScienceOn
9 El Hajj II, Hashash JG, Baz EM, et al (2007). ABO blood group and gastric cancer: rekindling an old fire? South Med J, 100, 726-7.   DOI
10 Ghazizadeh M, Kagawa S, Kurokawa K (1983). A, B, O (H) blood group antigen distribution in normal skin and squamous cell carcinoma of the penis. Urol Res, 11, 267-9.   DOI
11 Greer JB, Yazer MH, Raval JS, et al (2010). Significant association between ABO blood group and pancreatic cancer. World J Gastroenterol, 16, 5588-91.   DOI   ScienceOn
12 Guleria K, Singh HP, Kaur H (2005). ABO blood groups in gastrointestinal tract (GIT) and breast carcinoma patients. Anthropologist, 7, 189-92.
13 Henderson J, Seagrott V, Goldacre M (1993). Ovarian cancer and ABO blood groups. J Epidemiol Community Health, 47, 287-9.   DOI
14 Hosoi E (2008). Biological and clinical aspects of ABO blood group system. J Med Invest, 55, 174-82.   DOI   ScienceOn
15 Ichikawa D, Handa K, Hakomori S (1998). Histo-blood group A/B antigen deletion/reduction vs. continuous expression in human tumor cells as correlated with their malignancy. Int J Cancer, 76, 284-9.   DOI
16 Iodice S, Maisonneuve P, Botteri E, et al (2010). ABO blood group and cancer. Eur J Cancer, 46, 3345-50.   DOI   ScienceOn
17 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA: Cancer J Clin, 61, 69-90.   DOI
18 Jordon D, Jagirdar J, Kaneko M (1989). Blood group antigens, lewisx and lewisy in the diagnostic discrimination of malignant mesothelioma versus adenocarcinoma. Am J Pathol, 135, 931-7.
19 Jordan GH, Lynch DF (1983). Relationship of blood group to testicular carcinoma. Urology, 22, 265-7.   DOI   ScienceOn
20 Karakousis CP, Evlogimenos E, Suh O (1986). Blood groups and malignant melanoma. J Surg Oncol, 33, 24-6.   DOI   ScienceOn
21 Moldvay J, Scheid P, Wild P, et al (2000). Predictive survival markers in patients with surgically resected non-small cell lung carcinoma. Clin Cancer Res, 6, 1125-34.
22 Landsteiner K (1900). Zur kenntnis der antifermentativen, lytischen and agglutinierenden wirkungen des blutserums und der lymphe. Zentralbl Bakteriol, 27, 357-62.
23 Mittal VP (1970). Blood groups and cancer of the cervix uteri. J Obstet Gynaecol India, 20, 240-2.
24 Mehrazin M (2006). ABO blood group frequency and brain tumors. Asian Pac Cancer Prev, 7, 582-4.
25 Nakagoe T, Nanashima A, Sawai T, et al (2000). Expression of blood group antigens A, B, and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients. J Cancer Res Clin Oncol, 126, 375-82.   DOI   ScienceOn
26 Nozoe T, Ezaki T, Baba H, et al (2004). Correlation of ABO blood group with clinicopathologic characteristics of patients with esophageal squamous cell carcinoma. Dis Esophagus, 17, 1469.
27 Otley C (2006). Non-Hodgkin lymphoma and skin cancer: a dangerous combination. Australas J Dermatol, 47, 231-6.   DOI   ScienceOn
28 Pinkston JA, Cole P (1996). ABO blood groups and salivary gland tumors (Alabama, United States). Cancer Causes Control, 7, 572-4.   DOI
29 Pyd M, Rzewnicki I, Suwayach U (1995). ABO blood groups in patients with laryngeal and hypopharyngeal cancer. Otolaryngol Pol, 49, 396-401.
30 Rolfe KJ, Nieto JJ, Reid WM et al (2002). Is there a link between vulval cancer and blood group? Eur J Gynaecol Oncol, 23, 111-2.
31 Slater G, Itzkowitz S, Azar S, et al (1993) Clinicopathologic correlations of ABO and Rhesus blood type in colorectal cancer. Dis Colon Rectum, 36, 5-7.   DOI   ScienceOn
32 Vincenzo G, Marta G, Alessia G, et al (2011). ABO blood group and risk of cutaneous malignant melanoma. Eur J Cancer Prev, 20, 121-2.   DOI   ScienceOn
33 Su M, Lu SM, Tian DP, et al (2001). Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China. World J Gastroenterol, 7, 657-61.
34 Tursen U, Tiftik EN, Unal S, et al (2005). Relationship between ABO blood groups and skin cancers. Dermatol Online J, 11, 44.
35 Vadivelu MK, Damodaran S, Solomon J, et al (2004). Distribution of ABO blood groups in acute leukaemias and lymphomas. Ann Hematol, 83, 584-7.
36 Xie J, Qureshi AA, Li Y, Han J (2010). ABO blood group and incidence of skin cancer. PLoS One, 5, 11972.   DOI   ScienceOn