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http://dx.doi.org/10.7314/APJCP.2013.14.6.3891

Prognostic Significance of α5β1-integrin Expression in Cervical Cancer  

Wang, Hua-Yi (Department of Oncology, Zhongnan Hospital of Wuhan University)
Chen, Zhe (Department of Obstetrics and Gynecology, Jingzhou Second People Hospital)
Wang, Zhu-Hui (Department of Obstetrics and Gynecology, Jingzhou Second People Hospital)
Wang, Hong (Department of Pathology, Jingzhou Second People Hospital)
Huang, Li-Ming (Department of Oncology, Zhongnan Hospital of Wuhan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.6, 2013 , pp. 3891-3895 More about this Journal
Abstract
The purpose of this study was to evaluate the association of expression of ${\alpha}5{\beta}1$-integrin with clinicopathologic features and prognosis in cervical cancer. Levels of ${\alpha}5{\beta}1$-integrin in normal cervical mucosa and cervical cancer tissue were detected with immunohistochemistry. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. ${\alpha}5{\beta}1$-integrin expression was detected in 84.6% (143/169) cervical cancer samples, significantly different from that in normal cervical mucosa (P < 0.05). Positive expression rates of ${\alpha}5{\beta}1$-integrin in patients with poor histologic differentiation, lymph node metastasis, and recurrence were elevated. Using Kaplan-Meier analysis, a comparison of survival curves of low versus high expression of ${\alpha}5{\beta}1$-integrin revealed a highly significant difference in human cervical cancer cases (P < 0.05), suggesting that overexpression of ${\alpha}5{\beta}1$-integrin is associated with a worse prognosis.The ${\alpha}5{\beta}1$-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of cervical cancer. The current study indicated that ${\alpha}5{\beta}1$-integrin may be an independent prognostic factor for cervical cancer patients.
Keywords
Cervical cancer; ${\alpha}5{\beta}1$-integrin; prognosis; survival;
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