Browse > Article
http://dx.doi.org/10.7314/APJCP.2013.14.6.3663

Investigation of the Antioxidant Status in Multiple Myeloma Patients: Effects of Therapy  

Mehdi, Wesen A. (Department of Chemistry, University of Baghdad)
Zainulabdeen, Jwan A. (Department of Chemistry, University of Baghdad)
Mehde, Atheer A. (Department of Acceptable Analysis, Health and Medical Technical College)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.6, 2013 , pp. 3663-3667 More about this Journal
Abstract
Background: Multiple myeloma is a malignant silent incurable plasma cell disorder. The present study aimed to assessed the activation of the oxidative stress pathway in afected patients Materials and Methods: Advanced oxidation protein products (AOPPs), malondialdehyde (MDA), adenosine deaminase (ADA), total antioxidant capacity (TAC) levels, glutathione, ascorbic acid (vitamin C), ${\alpha}$-tocopherol (vitamin E) in addition to related enzymes glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R) and superoxide dismutase (SOD) were analyzed in sixty patients with multiple myeloma before and after one month treatment with induction therapy. Results: The results of the study showed a significant elevation in AOPPs, MDA, ADA levels in patients with multiple myeloma before and after treatment in comparison to healthy control samples In contrast TAC glutathione, vitamin C and E, and the antioxidant enzymes levels were decreased significantly. On comparing samples of MM patients after treatment, there was significant increase of TAC glutathione, vitamin C and E, and the antioxidant enzymes in parallel with decreasing AOPPs, MDA and ADA levels in comparison with samples of patients before treatment. Conclusions: The results indicate oxidative stress and DNA damage activity increase in MM and are alleviated in response to therapy.
Keywords
Multiple myeloma; oxidation byproducts; antioxidants; antioxidant enzymes; total antioxidant capacity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Alexander DD, Mink PJ, Adami HO, et al (2007). Multiple myeloma: a review of the epidemiologic literature. Int J Cancer, 120, 40-61.   DOI   ScienceOn
2 Beutler E, Duron O, Kelly BM (1963). Improved method for the determination of blood GSH. J Lab Clin Med, 61, 882-8.
3 Campanella A, Santambrogio P, Fontana F, et al (2012). Iron increases the susceptibility of multiple myeloma cells to bortezomib. Haematologica J, 10, 3324.
4 Chatterjea MN, Shinde R (2007). Textbook of medical biochemistry. 7th edn. Jaypee brothers medical publications, New Delhi. pp. 92-113.
5 Dierickx PJ (1999). Glutathione-dependent cytotoxicity of the chloroacetanilide herbicides alachlor, metolachlor, and propachlor in rat and human hepatoma-derived cultured cells. Cell Biol Toxicol, 15, 325-2.   DOI   ScienceOn
6 Estakhri R, Hajipour B, Majidi H, Soleimani H (2013). Vitamin E ameliorates cyclophosphamide induced nephrotoxicity. Life Sci J, 10, 308-13.
7 Giusti G (1974). Adenosine deaminase. In: Bergneyer HU, Methods of enzymatic analysis. 2nd Edn., Academic Press Inc., New York, pp. 1092-8.
8 Goljan E, Sloka KI (2008). Laboratory testing in clinical medicine. 1st edn. Mosby Elsevier Inc Publications, USA. pp. 283-6.
9 Hideshima T, Anderson KC (2002). Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer, 2, 927-37.   DOI   ScienceOn
10 Ishikawa K, Takenaga K, Akimoto M, et al (2008). ROSgenerating mitochondrial DNA mutations can regulate tumor cell metastasis. Science, 320, 661-4.   DOI   ScienceOn
11 Kaya E, Keskin L, Aydogdu I, et al (2005). Oxidant/antioxidant parameters and their relationship with chemotherapy in hodgkin's lymphoma. J Int Med Res, 33, 687-92.   DOI
12 Krzystek-Korpacka M, Patryn E, Boehm D, et al (2008). Advanced oxidation protein products (AOPPs) in juvenile overweight and obesity prior to and following weight reduction. Clinical Biochemistry, 41, 943-9.   DOI   ScienceOn
13 Kyle RA, Rajkumar SV (2004). Multiple myeloma. N Engl J Med, 351, 1860-73.   DOI   ScienceOn
14 Kyle RA, Rajkumar SV (2004) Plasma, cell disorders. In: Goldman L, Ausiello D, editors. Cecil textbook of medicine. Chapter 196. 2nd edn. Philadelphia, W.B. Saunders, pp. 1184-6.
15 Kyle RA, Rajkumar SV (2008). Multiple myeloma. Blood, 15, 2962-72.
16 Kyle RA, Rajkumar SV (2009). Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia, 23, 3-9.   DOI   ScienceOn
17 Lee K, Koon IT, Mee AS (1975). A new colorimetric method for the determination of NADH/NADPH dependent GSSGRed in erythrocyte and in plasma. Clinica Chimica Acta, 58, 101-8.   DOI   ScienceOn
18 Lenhinger AL (2005). Principles of biochemistry" 4th edn., H. Freeman and Company. New York, pp. 94.
19 Marnett LJ, Riggins JN, West JD (2003). Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. J Clin Invest, 111, 583-93.   DOI
20 Marquez A, Villa-Trevino S, Gueraud F (2007). The LEC rat: a useful model for studying liver carcinogenesis related to oxidative stress and inflammation. Redox Rep, 12, 35-9.   DOI
21 Munshi N (1997). Immunoregulatory mechanisms in multiple myeloma. Hematol Oncol Clin North Am, 11, 51-69.   DOI
22 Mehde A, Mehdi W, Jasim A (2013). Study several biochemical parameters into patient's with hepatitis B virus global. J Med Res Diseases, 13, 210.
23 Camilla R, Suzuki H, Dapra V, et al (2011). Oxidative stress and galactose-deficient IgA1 as markers of progression in IgA nephropathyst. Clin J Am Soc Nephrol, 6, 1903-11   DOI   ScienceOn
24 Misra HP, Fridovich I (1972). The role of superoxide anion in the auto oxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem, 247, 3170-5.
25 O'Connell TX, Horita TJ, Kasravi B (2005). Understanding and Interpreting serum protein electrophoresis. Am Fam Physician, 71, 105-12.
26 Ottaviano FG, Handy, DE, Loscalzo J (2008). Redox regulation in the extracellular environment. Circ J, 72, 1-16.   DOI   ScienceOn
27 Pleban PA, Munyani A, Beachum J (1982). Determination of selenium concentration and glutathione peroxidase activity in plasma and erythrocytes. Clin Chem, 28, 311-6.
28 Raab MS, Podar K, Breitkreutz I, et al (2009). Multiple myeloma. Lancet, 374, 324-39.   DOI   ScienceOn
29 Ravaud P, Thepot C, Auleley GR, Amor B (1996). Imaging of multiple myeloma. Ann Med Interne, 147, 370-5.
30 Rice-Evans C, Mille NJ (1994). Total antioxidant status in sera and body fluids. In: Methods in Enzymology. New York: Academic Press, pp. 279-93.
31 Satoh K (1978). Plasma lipid peroxide in cerebrovascular disorders determined by new colorimetric method. Clin Chim Acta, 90, 37-43.   DOI   ScienceOn
32 Xuan-li Xu, Yi-hong S, Shen Q, Jian-ying Z (2013). Case of bilateral pleural effusion as the first sign of multiple myeloma. Eur J Med Res, 18, 7.   DOI
33 Sharma A, Tripathi M, Satyam A, Kumar L (2009). Study of antioxidant levels in patients with multiple myeloma. Leuk Lymphoma, 50, 809-15.   DOI   ScienceOn
34 Waris G, Ahsan H (2006). Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinogenesis, 14, 14-21.