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http://dx.doi.org/10.7314/APJCP.2013.14.5.3369

Dilemmas of Oral Cancer Screening: An Update  

Kujan, Omar (Department of Oral Medicine and Diagnostic Sciences, School of Dentistry, Al-Farabi College)
Sloan, Philip (School of Dental Sciences, University of Newcastle)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.5, 2013 , pp. 3369-3373 More about this Journal
Abstract
Oral cancer is a global health burden with high mortality and morbidity. Advances in treatment have failed to improve the relatively poor survival rate due to late-stage diagnosis. Early detection and screening have been shown to be effective in reducing mortality and morbidity of most common cancers. Several studies have evaluated the effectiveness of oral cancer screening programs but clear results were not obtained. This narrative commentary aimed to give a critical insight into the dilemma of oral cancer screening and to suggest recommendations for future trends. Conventional oral examination still constitutes the gold standard screening tool for potentially malignant oral lesions and cancer. Interestingly, the findings of the most lasting (15-year) randomized controlled trial on oral cancer screening using visual examination (Kerala) supported the introduction of a screening program in high-risk individuals. Several screening adjuncts exist but are still not at the introduction stage. Further research to find an appropriate adjunct reliable tool for oral cancer screening is needed. In conclusion, oral cancer fulfills most of the essential principles of cancer screening but still many points need to be clarified. Therefore, there is a striking need to establish a global consortium on oral cancer screening that will oversee research and provide recommendations for health authorities at regular intervals.
Keywords
Oral; cancer; screening; diagnostic aids;
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1 Awan KH, Morgan PR, Warnakulasuriya S (2011). Evaluation of an autofluorescence based imaging system $(VELscope^{TM})$ in the detection of oral potentially malignant disorders and benign keratoses. Oral Oncol, 47, 274-7.   DOI   ScienceOn
2 Begg C, Cho M, Eastwood S, et al (1996). Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA, 276, 637-9.   DOI   ScienceOn
3 British Dental Association (2000). Opportunistic oral cancer screening: a management for dental practice. BDA Occasional. Paper 6: 1-36, 2000.Available from:www.bda.org/Images/mouth_cancer.pdf.
4 Brocklehurst P, Kujan O, Glenny AM, et al (2010). Screening programmes for the early detection and prevention of oral cancer. Cochrane Database Syst Rev 11, CD004150.
5 Epstein JB, Gorsky M, Cabay RJ, Day T, Gonsalves W (2008). Screening for and diagnosis of oral premalignant lesions and oropharyngeal squamous cell carcinoma. Can Fam Physician, 54, 870-5.
6 Fedele S (2009). Diagnostic aids in the screening of oral cancer. Head Neck Oncol, 1, 5.   DOI   ScienceOn
7 Ferlay J, Shin HR, Bray F, et al (2010). GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer. Available from: http://globocan.iarc.fr.
8 Johnson NW, Warnakulasuriya S, Gupta PC, et al (2011). Global oral health inequalities in incidence and outcomes for oral cancer: causes and solutions. Adv Dent Res, 23, 237-46.   DOI
9 Kammerer PW, Koch FP, Santoro M, et al (2013). Prospective, blinded comparison of cytology and DNA-image cytometry of brush biopsies for early detection of oral malignancy. Oral Oncol, 12, 1368-8375.
10 Kerr AR, Sirois DA, Epstein JB (2006).Clinical evaluation of chemiluminescent lighting: an adjunct for oral mucosal examinations. J Clin Dent, 17, 59-63.
11 KujanOa, Duxbury AJ, Glenny AM, Thakker NS, Sloan P (2006). Opinions and attitudes of the UK's GDPs and specialists in oral surgery, oral medicine and surgical dentistry on oral cancer screening. Oral Dis, 12, 194-9.   DOI   ScienceOn
12 Kujan Ob, Glenny AM, Oliver RJ, Thakker N, Sloan P (2006). Screening programmes for the early detection and prevention of oral cancer. Cochrane Database Syst Rev, 3, 4150.
13 Kujan O, Glenny AM, Sloan P (2005). Screening for oral cancer. Lancet, 366, 1265-6.   DOI   ScienceOn
14 Lavelle CL, Scully C (2005). Criteria to rationalize population screening to control oral cancer. Oral Oncol, 41, 11-6.   DOI   ScienceOn
15 Lingen MW, Kalmar JR, Karrison T, Speight PM (2008). Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncol, 44, 10-22.   DOI   ScienceOn
16 Lingen MW (2011). Assuring dental student head and neck cancer screening competency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 111, 267-8.   DOI   ScienceOn
17 Lingen MW (2010). Screening for oral premalignancy and cancer: what platform and which biomarkers? Cancer Prev Res (Phila), 3, 1056-9.   DOI   ScienceOn
18 Macek MD (2011). Using toluidine blue as an adjunct to oral visual cancer screening among high-risk individuals may lead to increased detection of oral submucous fibrosis. J Evid Based Dent Pract, 11, 200-2.   DOI   ScienceOn
19 McGee S, Mirkovic J, Mardirossian V, et al (2008). Model-based spectroscopic analysis of the oral cavity: impact of anatomy. J Biomed Opt, 13, 64034.   DOI   ScienceOn
20 McIntosh L, McCullough MJ, Farah CS (2009). The assessment of diffused light illumination and acetic acid rinse (Microlux/DL) in the visualisation of oral mucosal lesions. Oral Oncol, 45, 227-31.   DOI   ScienceOn
21 McNamara KK, Martin BD, Evans EW, Kalmar JR (2012). The role of direct visual fluorescent examination (VELscope) in routine screening for potentially malignant oral mucosal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 114, 636-43.   DOI   ScienceOn
22 Ovchinnikov DA, Cooper MA, Pandit P, et al (2012). Tumorsuppressor Gene Promoter Hypermethylation in Saliva of Head and Neck Cancer Patients. Transl Oncol, 5, 321-6.   DOI
23 Pierce MC, Schwarz RA, Bhattar VS, et al (2012). Accuracy of in vivo multimodal optical imaging for detection of oral neoplasia. Cancer Prev Res (Phila), 5, 801-9.   DOI
24 Ramadas K, Arrossi S, Thara S, Sankaranarayanan R (2006). Keynote comment: importance of recognising scientific evidence. Lancet Oncol, 7, 962-3.   DOI   ScienceOn
25 Ramadas K, Sankaranarayanan R, Jacob BJ, et al (2003). Interim results from a cluster randomized controlled oral cancer screening trial in Kerala, India. Oral Oncol, 39, 580-8.   DOI   ScienceOn
26 Rethman MP, Carpenter W, Cohen EE, et al (2010). American dental association council on scientific affairs expert panel on screening for oral squamous cell carcinomas. evidencebased clinical recommendations regarding screening for oral squamous cell carcinomas. J Am Dent Assoc, 141, 509-20.   DOI
27 Sankaranarayanan R, Mathew B, Jacob BJ, et al (2000). Early findings from a community-based, cluster-randomized, controlled oral cancer screening trial in Kerala, India. The Trivandrum Oral Cancer Screening Study Group. Cancer, 88, 664-73.   DOI
28 Sankaranarayanan R, Sauvaget C, Ramadas Km, et al (2011). Clinical trials of cancer screening in the developing world and their impact on cancer healthcare. Ann Oncol, 22, 20-28.
29 Sankaranarayanan R, Ramadas K, Thara S, et al (2013). Long term effect of visual screening on oral cancer incidence and mortality in a randomized trial in Kerala, India. Oral Oncol, 49, 314-21.   DOI   ScienceOn
30 Sankaranarayanan R, Ramadas K, Thomas G, et al (2005). Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial. Lancet, 365, 1927-33.   DOI   ScienceOn
31 Schwarz RA, Gao W, Stepanek VM, et al (2010). Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia. Biomed Opt Express, 2, 89-99.
32 Seoane-Leston J, Diz Dios P (2010). Diagnostic clinical aids in oral cancer. Oral Oncol, 46, 418-22.   DOI   ScienceOn
33 Seoane-Romero JM, Vazquez-Mahia I, Seoane J, Varela-Centelles P, Tomas I, Lopez-Cedrun JL (2012). Factors related to late stage diagnosis of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal, 17, 35-40.
34 Smith RA, Cokkinides V, Brooks D, Saslow D, Shah M, Brawley OW (2011). Cancer screening in the United States, 2011: A review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin, 61, 8-30.   DOI
35 Speight PM, Warnakulasuriya S (2010). Evaluation of screening for oral cancer against National Screening Committee Criteria. UK National Screening Committee Publications. Pages 1-13, 2010. Available from: http://www.screening.nhs.uk/oralcancer.
36 Su WW, Yen AM, Chiu SY, Chen TH (2010). A communitybased RCT for oral cancer screening with toluidine blue. J Dent Res, 89, 933-7.   DOI   ScienceOn
37 Warnakulasuriya S (2009). Global epidemiology of oral and oropharyngeal cancer. Oral Oncol, 45, 309-16.   DOI   ScienceOn
38 Subramanian S, Sankaranarayanan R, Bapat B, et al (2009). Cost-effectiveness of oral cancer screening: results from a cluster randomized controlled trial in India. Bull World Hlth Organ, 87, 200-6.   DOI   ScienceOn
39 Tang H, Wu Z, Zhang J, Su B (2013). Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Mol Med Report, 7, 761-6.
40 Tyagi A, Miller K, Cockburn M (2012). e-Health tools for targeting and improving melanoma screening: a review. J Skin Cancer, 2012, 8.