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http://dx.doi.org/10.7314/APJCP.2013.14.5.3351

Benzochloroporphyrin Derivative Induced Cytotoxicity and Inhibition of Tumor Recurrence During Photodynamic Therapy for Osteosarcoma  

Gong, Hai-Yang (Musculoskeletal Oncology Center, Shanghai Tenth People's Hospital, Tongji University, School of Medicine)
Sun, Meng-Xiong (Musculoskeletal Oncology Center, Shanghai Tenth People's Hospital, Tongji University, School of Medicine)
Hu, Shuo (Musculoskeletal Oncology Center, Shanghai Tenth People's Hospital, Tongji University, School of Medicine)
Tao, Ying-Ying (Department of Pharmacology, Jinling Hospital)
Gao, Bo (Musculoskeletal Oncology Center, Shanghai Tenth People's Hospital, Tongji University, School of Medicine)
Li, Guo-Dong (Musculoskeletal Oncology Center, Shanghai Tenth People's Hospital, Tongji University, School of Medicine)
Cai, Zheng-Dong (Musculoskeletal Oncology Center, Shanghai Tenth People's Hospital, Tongji University, School of Medicine)
Yao, Jian-Zhong (Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.5, 2013 , pp. 3351-3355 More about this Journal
Abstract
Photodynamic therapy (PDT) is a promising cancer treatment modality that uses dye-sensitized photooxidation of biologic matter in target tissue. This study explored effects of the photosensitizer BCPD-17 during PDT for osteosarcoma. LM-8 osteosarcoma cells were treated with BCPD-17 and cell viability after laser irradiation was assessed in vitro with the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. The effects of BCPD-17 during PDT recurrence were then examined on tumor-bearing mice in vivo. BCPD-17 had dosedependent cytotoxic effects on LM-8 osteosarcoma cells after laser irradiation which also had energy-dependent effects on the cells. The rate of local recurrence was reduced when marginal resection of mice tumors was followed by BCPD-17-mediated PDT. Our results indicated BCPD-17-mediated PDT in combination with marginal resection of tumors is a potentially new effective treatment for osteosarcoma.
Keywords
Inhibiting rate; photochemotherapy; apoptosis/drug effects; photosensitizing agents;
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