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http://dx.doi.org/10.7314/APJCP.2013.14.5.3155

Meta-analysis of the CYP1A2 -163C＞A Polymorphism and Lung Cancer Risk  

Deng, Sheng-Qiong (Department of Preventive Medicine, Institute of Basic Medical Sciences, Hubei University of Medicine)
Zeng, Xian-Tao (Department of Stomatology, Taihe Hospital, Hubei University of Medicine)
Wang, Yun (Department of Respiratory Medicine, Taihe Hospital, Hubei University of Medicine)
Ke, Qing (Department of Oncology, Taihe Hospital, Hubei University of Medicine)
Xu, Qiong-Li (Department of Stomatology, Taihe Hospital, Hubei University of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.5, 2013 , pp. 3155-3158 More about this Journal
Abstract
Many published studies have concerned associations between the CYP1A2 -163 C>A polymorphism and risk of lung cancer, but the results have been inconsistent. Therefore, we performed a meta-analysis to obtain a more precise estimate. We searched the PubMed database up to March 1, 2013 for relevant cohort and case-control studies. Supplementary search was conducted manually by searching the references of the included studies and relevant meta-analyses. A meta-analysis was performed using RevMan 5.2 software for calculation of pooled odds ratios (ORs) and relevant 95% confidence intervals (CIs) after data extraction. Finally, seven case-control studies and one nested case-control study involving 1,675 lung cancer patients and 2,393 controls were included. The meta-analysis showed that there was no association of CYP1A2 -163 C>A polymorphism with risk of lung cancer overall [(OR=0.89, 95%CI= 0.74-1.07) for C vs. A; (OR=0.73, 95%CI= 0.50-1.07) for AA vs. CC ; (OR=0.82, 95%CI= 0.62-1.09) for AC vs. CC; (OR=0.79, 95%CI= 0.58-1.07) for (AC+AA) vs. CC; and (OR=0.87, 95%CI= 0.67-1.13) for AA vs. (CC+AC)]. Subgroup analysis indicated that there was an associationbetween CYP1A2 -163C>A polymorphism and lung cancer risk for population-based controls, a trend risk for SCCL (squamous cell carcinoma of lung) and Caucasians. These results suggested that -163 C>A polymorphism is likely to be associated with risk of lung cancer compared with population-based controls.
Keywords
CYP1A2 rs762551 polymorphism; lung cancer; meta-analysis;
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