Browse > Article
http://dx.doi.org/10.7314/APJCP.2013.14.5.3117

Obesity and Risk of Bladder Cancer: A Meta-analysis of Cohort Studies  

Qin, Qi (Department of General Surgery, Childrens Hospital, Zhejiang University School of Medicine)
Xu, Xin (Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine)
Wang, Xiao (Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine)
Zheng, Xiang-Yi (Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.5, 2013 , pp. 3117-3121 More about this Journal
Abstract
Objective: Previous epidemiologic studies demonstrated that obesity might associated with the risk of bladder cancer. However, many of the actual association findings remained conflicting. To better clarify and provide a comprehensive summary of the correlation between obesity and bladder cancer risk, we conducted a meta-analysis to summarize results of studies on the issue. Stratified analyses were also performed on potential variables and characteristics. Methods: Studies were identified by searching in PubMed and Wanfang databases, covering all the papers published from their inception to March 10, 2013. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated by either random-effect or fixed-effect models. Results: A total of 11 cohort studies were included in our meta-analysis, which showed that obesity was associated with an increased risk for bladder cancer in all subjects (RR=1.10, 95% CI=1.06-1.16; p=0.215 for heterogeneity; $I^2$=24.0%). Among the 9 studies that controlled for cigarette smoking, the pooled RR was 1.09 (95% CI 1.01-1.17; p=0.131 for heterogeneity; $I^2$=35.9%). No significant publication bias was detected (p = 0.244 for Egger's regression asymmetry test). Conclusions: Our results support the conclusion that obesity is associated with the increased risk of bladder cancer. Further research is needed to generate a better understanding of the correlation and to provide more convincing evidence for clinical intervention in the prevention of bladder cancer.
Keywords
Obesity; bladder cancer; risk; meta-analysis; smoking; confounding factor;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101.   DOI   ScienceOn
2 Chen HS, Su LT, Lin SZ, et al (2012). Increased risk of urinary tract calculi among patients with diabetes mellitus--a population-based cohort study. Urology, 79, 86-92.   DOI   ScienceOn
3 Chow WH, Lindblad P, Gridley G, et al (1997). Risk of urinary tract cancers following kidney or ureter stones. J Natl Cancer Inst, 89, 1453-7.   DOI   ScienceOn
4 DerSimonian R, Laird N(1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88.   DOI   ScienceOn
5 Dunn SE, Kari FW, French J, et al (1997). Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res, 57, 4667-72.
6 Egger M, Davey Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34.   DOI   ScienceOn
7 Flegal KM, Graubard BI, Williamson DF, Gail MH (2005). Excess deaths associated with underweight, overweight, and obesity. JAMA, 293, 1861-7.   DOI   ScienceOn
8 Funfstuck R, Nicolle LE, Hanefeld M, Naber KG (2012). Urinary tract infection in patients with diabetes mellitus. Clin Nephrol, 77, 40-8.   DOI
9 Haggstrom C, Stocks T, Rapp K, et al (2011). Metabolic syndrome and risk of bladder cancer: prospective cohort study in the metabolic syndrome and cancer project (Me-Can). Int J Cancer, 128, 1890-8.   DOI   ScienceOn
10 Jankovic S, Radosavljevic V (2007). Risk factors for bladder cancer. Tumori, 93, 4-12.
11 Jee SH, Yun JE, Park EJ, et al (2008). Body mass index and cancer risk in Korean men and women. Int J Cancer, 123, 1892-6.   DOI   ScienceOn
12 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
13 Jones ME, Swerdlow AJ (1998). Bias in the standardized mortality ratio when using general population rates to estimate expected number of deaths. Am J Epidemiol, 148, 1012-7.   DOI   ScienceOn
14 Key TJ, Appleby PN, Reeves GK, Roddam AW(2010). Insulinlike growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol, 11, 530-42.   DOI   ScienceOn
15 Koebnick C, Michaud D, Moore SC, et al (2008). Body mass index, physical activity, and bladder cancer in a large prospective study. Cancer Epidemiol Biomarkers Prev, 17, 1214-21.   DOI   ScienceOn
16 Larsson SC, Andersson SO, Johansson JE, Wolk A (2008). Diabetes mellitus, body size and bladder cancer risk in a prospective study of Swedish men. Eur J Cancer, 44, 2655-60.   DOI   ScienceOn
17 Siegel R, Naishadham D, Jemal A (2013). Cancer statistics, 2013. CA Cancer J Clin, 63, 11-30.   DOI   ScienceOn
18 Mantel N, Haenszel W(1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
19 Murta-Nascimento C, Schmitz-Drager BJ, Zeegers MP, et al (2007). Epidemiology of urinary bladder cancer: from tumor development to patient's death. World J Urol, 25, 285-95.   DOI   ScienceOn
20 Rinaldi S, Cleveland R, Norat T, et al (2010). Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies. Int J Cancer, 126, 1702-15.
21 Zhao H, Grossman HB, Spitz MR, et al (2003). Plasma levels of insulin-like growth factor-1 and binding protein-3, and their association with bladder cancer risk. J Urol, 169, 714-7.   DOI   ScienceOn