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http://dx.doi.org/10.7314/APJCP.2013.14.5.3063

Upregulation of MicroRNA 181c Expression in Gastric Cancer Tissues and Plasma  

Cui, Mei-Hua (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University)
Hou, Xiao-Lin (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University)
Lei, Xiao-Yan (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University)
Mu, Fang-Hong (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University)
Yang, Gui-Bin (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University)
Yue, Lin (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University)
Fu, Yi (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University)
Yi, Guo-Xing (Department of Gastroenterology, Aerospace Center Hospital, Aerospace Clinical Medical College, Peking University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.5, 2013 , pp. 3063-3066 More about this Journal
Abstract
Objective: To test the microRNA-181c (miR-181c) expression in tissues and plasma of gastric cancer (GC) cases, analyze any correlations, and explore the possibility of miR-181c as a potential molecular marker for GC diagnosis. Materials and Methods: Relative miR-181c expression levels in cancers and plasma from 30 GC patients was tested using reverse transcription-real-time fluorescent quantitation PCR and compared to that in samples from 30 gastric ulcer and 30 chronic gastritis patients. Results: The miR-181c expression level in the GC tissues was significantly higher than that in the gastric ulcer and chronic gastritis tissues (P = 0.000), as was the miR-181c expression level in the GC plasma (P = 0.000). We determined that miR-181c expression in GC plasma was positively correlated to its expression in the GC tissues (P = 0.000). Conclusions: The expression of miR-181c is upregulated in GC tissues and plasma, and the miR-181c expression level in GC plasma is positively correlated to that in the corresponding cancer tissues. Plasma miR-181c is possibly a new serological marker for GC diagnosis.
Keywords
MicroRNA; 181c (miR-181c); gastric cancer; plasma; cancer tissue;
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