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http://dx.doi.org/10.7314/APJCP.2013.14.4.2515

Total Laparoscopic Hysterectomy Versus Total Abdominal Hysterectomy for Endometrial Cancer: A Meta-analysis  

Wang, Hui-Ling (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xinxiang Medical University)
Ren, Yan-Fang (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xinxiang Medical University)
Yang, Jun (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xinxiang Medical University)
Qin, Rui-Ying (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xinxiang Medical University)
Zhai, Kai-Hua (Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.4, 2013 , pp. 2515-2519 More about this Journal
Abstract
The standard surgery for early-stage endometrial cancer is total abdominal hysterectomy (TAH), while total laparoscopic hysterectomy (TLH) is less invasive and assumed to be associated with lower morbidity. This meta-analysis was performed to investigate the effects of TLH versus TAH in women with early-stage endometrial cancer. We searched the PubMed, EMBASE, CBM and Cochrane Review databases for randomized trials assessing the effects of TLH versus TAH in women with early-stage endometrial cancer. The relative risks (RR) with 95% confidence intervals (CIs) from each study were pooled using meta-analysis. In our study, 9 randomized trials with a total of 1,263 patients were included. Meta-analyses showed that TLH was associated with lower risks of major complications (RR = 0.53, 95%CI 0.29-0.98, P = 0.042), total complications (RR = 0.59, 95%CI 0.42-0.82, P = 0.002) and postoperative complications (RR = 0.57, 95%CI 0.40-0.83, P = 0.003). However, there were no obvious differences in risks of intra-operative complications (RR = 0.98, 95%CI 0.62-1.55, P = 0.919) and mortality (RR = 0.96, 95%CI 0.66-1.40, P = 0.835). In conclusion, our results provide new evidence of a benefit for TLH over TAH in terms of major complications, total complications and postoperative complications in endometrial cancer patients.
Keywords
Endometrial cancer; total abdominal hysterectomy; total laparoscopic hysterectomy; meta-analysis;
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