Browse > Article
http://dx.doi.org/10.7314/APJCP.2013.14.3.1937

Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects  

Sun, Guo-Gui (Department of Chemoradiation Therapy, Tangshan People's Hospital)
Wang, Ya-Di (Department of Radiotherapy, The Military General Hospital of Beijing PLA)
Lu, Yi-Fang (Department of Endocrinology, Tangshan Workers Hospital)
Hu, Wan-Ning (Department of Chemoradiation Therapy, Tangshan People's Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.3, 2013 , pp. 1937-1943 More about this Journal
Abstract
Altered expression or function of manganese superoxide dismutase (MnSOD) has been shown to be associated with cancer risk but assessment of gene polymorphisms has resulted in inconclusive data. Here a search of published data was made and 22 studies were recruited, covering 20,025 case and control subjects, for meta-analyses of the association of MnSOD polymorphisms with the risk of prostate, esophageal, and lung cancers. The data on 12 studies of prostate cancer (including 4,182 cases and 6,885 controls) showed a statistically significant association with the risk of development in co-dominant models and dominant models, but not in the recessive model. Subgroup analysis showed there was no statistically significant association of MnSOD polymorphisms with aggressive or nonaggressive prostate cancer in different genetic models. In addition, the data on four studies of esophageal cancer containing 620 cases and 909 controls showed a statistically significant association between MnSOD polymorphisms and risk in all comparison models. In contrast, the data on six studies of lung cancer with 3,375 cases and 4,050 controls showed that MnSOD polymorphisms were significantly associated with the decreased risk of lung cancer in the homozygote and dominant models, but not the heterozygote model. A subgroup analysis of the combination of MnSOD polymorphisms with tobacco smokers did not show any significant association with lung cancer risk, histological type, or clinical stage of lung cancer. The data from the current study indicated that the Ala allele MnSOD polymorphism is associated with increased risk of prostate and esophageal cancers, but with decreased risk of lung cancer. The underlying molecular mechanisms warrant further investigation.
Keywords
Manganese superoxide dismutase; polymorphism; prostate cancer; esophageal cancer; lung cancer;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Choi JY, Neuhouser ML, Barnett MJ, et al (2008). Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort. Carcinogenesis, 29, 964-70.   DOI   ScienceOn
2 DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88.   DOI   ScienceOn
3 di Martino E, Hardie LJ, Wild CP, et al (2007). The NAD(P)H, quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma. Genet Med, 9, 341-7.   DOI
4 Egan KM, Thompson PA, Titus-Ernstoff L, Moore JH, Ambrosone CB (2003). MnSOD polymorphism and breast cancer in a population-based case-control study. Cancer Lett, 199, 27-33.   DOI   ScienceOn
5 Ergen HA, Narter F, Timirci O, Isbir T (2007). Effects of manganese superoxide dismutase Val-9Ala polymorphism on prostate cancer. Anticancer Res, 27, 1227-30.
6 Ho JC, Mak JC, Ho SP, et al (2006). Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels, and lung cancer risk in Chinese in Hong Kong. J Thorac Oncol, 1, 648-53.   DOI
7 Hung RJ, Boffetta P, Brennan P, et al (2004). Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk. Carcinogenesis, 25, 973-8.   DOI   ScienceOn
8 Iguchi T, Sugita S, Wang CY, et al (2009). MnSOD genotype and prostate cancer risk as a function of NAT genotype and smoking status. In Vivo, 23, 7-12.
9 Iguchi T, Wang CY, Delongchamps NB, et al (2008). Association of prostate cancer and manganese superoxide dismutase AA genotype influenced by presence of occult cancer in control group. Urology, 72, 238-41.   DOI   ScienceOn
10 Zejnilovic J, Akev N, Yilmaz H, Isbir T (2009). Association between manganese superoxide dismutase polymorphism and risk of lung cancer. Cancer Genet Cytogenet, 189, 1-4   DOI   ScienceOn
11 Zhang HJ, Yan T, Oberley TD, Oberley LW (1999). Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype. Cancer Res, 59, 6276-83,.
12 Zhao Y, Xuo Y, Oberley LW (2001). Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis mode. Cancer Res, 61, 6082-8.
13 Zhong W, Oberley LW, Oberley TD, St Clair DK (1997). Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene, 14, 481-90.   DOI   ScienceOn
14 Zhong W, Oberley LW(2005). Suppression of malignant phenotype of human glioma cells by overexpression of Manganese superoxide dismutase. Oncogene, 14, 481-90.
15 Zwacka RM, Duds L, Epperly MW, et al (1993). Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Nate Acad Sci USA, 90, 3113-7.   DOI   ScienceOn
16 Kang D, Lee KM, Park SK, et al (2007). Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study. Cancer Epidemiol Biomarkers Prev, 16, 1581-6.   DOI   ScienceOn
17 Komatsu M, Kuroda M, Wang Y, et al (2005). Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line. Int J Oncology, 26, 853-62.
18 Li H, Kantoff PW, Giovannucci E, et al (2005). Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer. Cancer Res, 65, 2498-504.   DOI   ScienceOn
19 Li N, Oberley TD, Oberley LW, Zhong W (1998). Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype. Prostate, 35, 221-33.   DOI   ScienceOn
20 Lin P, Hsueh YM, Ko JL, et al (2003). Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan. Lung Cancer, 40, 123-9.   DOI   ScienceOn
21 Liu G, Zhou W, Park S, et al (2004). The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms. Cancer, 101, 2802-8.   DOI   ScienceOn
22 Mantel-Haenszel, Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
23 Mikhak B, Hunter DJ, Spiegelman D, et al (2008). Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk. Carcinogenesis, 29, 2335-40.   DOI   ScienceOn
24 Mitrunen K, Sillanpaa V, Kataja M, et al (2001). Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk. Carcinogenesis, 22, 827-9.   DOI   ScienceOn
25 Cai Q, Shu XO, Wen W, et al (2004). Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk, results from the Shanghai Breast Cancer Study. Breast Cancer Res, 6, 647-55.   DOI   ScienceOn
26 Ambrosone CB, Freudenheim JL, Thompson PA, et al (1999), Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer Res, 59, 602-6.
27 Arsova-Sarafinovska Z, Matevska N, Petrovski D, et al (2008). Manganese superoxide dismutase (MnSOD) genetic polymorphism is associated with risk of early-onset prostate cancer. Cell Biochem Funct, 26, 771-7.   DOI   ScienceOn
28 Bica CG, de Moura da Silva LL, et al (2009). MnSOD gene polymorphism association with steroid-dependent cancer. Pathol Oncol Res, 15, 19-24.   DOI   ScienceOn
29 Cheng YJ, Wang YD, Liu Q, et al (2009). Occurrence and development relation between superoxide dismutase gene polymorphism and esophagus. Chin J Oncol, 31, 831-5.
30 Choi JY, Neuhouser ML, Barnett M, et al (2007). polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. Cancer Epidemiol Biomarkers Prev, 16, 1115-20.   DOI   ScienceOn
31 Soini Y, Vakkala M, Kahlos K Pääkkö P, Kinnula V (2001). MnSOD expression is less frequent in tumour cells of invasive breast carcinomas than in situ carcinomas or nonneoplastic breast epithelial cells. J Pathol, 195, 156-62.   DOI   ScienceOn
32 Murphy SJ, Hughes AE, Patterson CC, et al (2007). A populationbased association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma. Carcinogenesis, 28, 1323-28.   DOI   ScienceOn
33 Oberley TD (2004). Mitochondria, manganese superoxide dismutase, and cancer. Antioxid Redox Signal, 6, 483-7.   DOI   ScienceOn
34 Orrenius S, Gogvadze V, Zhivotovsky B (2007). Mitochondrial oxidative stress, implications for cell death. Annu Rev Pharmacol Toxicol, 47, 143-83.   DOI   ScienceOn
35 Sun GG,Hu WN,Wang YD,Yang CR,Lu YF (2012). Bidirectional regulation of manganese superoxide dismutase (MnSOD) on the radiosensitivity of esophageal cancer cells. Asian Pac J Cancer Prev, 13, 1-9.   과학기술학회마을   DOI   ScienceOn
36 Sun L, Konig IR, Homann N (2009). Manganese superoxide dismutase (MnSOD) polymorphism, alcohol, cigarette smoking and risk of oesophageal cancer. Alcohol Alcohol, 44, 353-7.   DOI   ScienceOn
37 Sutton A, Khoury H, Prip-Buus C, et al (2003). The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics, 13, 145-57.   DOI   ScienceOn
38 Swerissen H, Belfrage J, Weeks A, et al (2006). A randomised control trial of a self-management program for people with a chronic illness from Vientnamese, Chinese, Italian and Greek backgrounds. Patient Educ Couns, 64, 360-8.   DOI   ScienceOn
39 Taufer M, Peres A, de Andrade VM, et al (2005). Is the Val16Ala manganese superoxide dismutase polymorphism associated with the aging process? J Gerontol A Biol Sci Med Sci, 60, 432-438.   DOI   ScienceOn
40 Tong SY, Lee JM, Song ES, et al (2009). Functional polymorphism in manganese superoxide dismutase and antioxidant status, their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer. Gynecol Oncol, 115, 272-6.   DOI   ScienceOn
41 Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P (2009). Redox regulation of cell Survival. Antioxid Redox Signal, 10, 1343-74.
42 Wang LI, Miller DP, Sai Y, et al (2001). Manganese superoxide dismutase alanine-to-valine polymorphism at codon 16 and lung cancer risk. J Natl Cancer Inst, 93, 1818-21.   DOI   ScienceOn
43 Wang LI, Neuberg D, Christiani DC (2004). Asbestos exposure, manganese superoxide dismutase (MnSOD) genotype, and lung cancer risk. J Occup Environ Med, 46, 556-64.   DOI   ScienceOn
44 Wang MC, Guo MF, Zhao GQ (2006). Research on mRNA expression level of MnSOD gene in prostate cancer and benign prostatic hyperplasia tissue. Chin J Gerontol, 26, 164-5.
45 Wang S, Wang F, Shi X, et al (2009). Association between manganese superoxide dismutase (MnSOD) Val-9Ala polymorphism and cancer risk-A meta-analysis. Eur J Cancer, 45, 2874-81.   DOI   ScienceOn
46 Wang Y, Kuroda M, Gao XS, et al (2005). Hydrogen peroxide overload increases adriamycin-induced apoptosis of SaOS2FM, a manganese superoxide dismutaseoverexpressing human osteosarcoma cell line. Int J Oncol, 26, 1291-300.
47 Woodson K, Tangrea JA, Lehman TA, et al (2001). Manganese superoxide dismutase (MnSOD) polymorphism, alphatocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland). Cancer Causes Control, 14, 513-8.
48 Yan T, Oberley LW, Zhong W, St Clair DK (1996). Manganesecontaining superoxide dismutase overexpression causes phenotypic reversion in SV-40 transformed human lung fibroblasts. Cancer Res, 56, 2864-71.