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http://dx.doi.org/10.7314/APJCP.2013.14.3.1841

Salvage Therapy of Gemcitabine Plus Endostar Significantly Improves Progression-free Survival (PFS) with Platinum-resistant Recurrent Epithelial Ovarian Cancer  

Su, An (Department of Medical Oncology, Zhongshan Hospital of Xiamen University)
Zhang, Jing (Department of Hematological Oncology, Cancer Center of Sun-Yat Sen University)
Pan, Zhan-He (Department of Medical Oncology, Zhongshan Hospital of Xiamen University)
Zhou, Qi-Ming (Department of Medical Oncology, Nanshan District Hospital of Shenzhen)
Lv, Xia (Department of Medical Oncology, Zhongshan Hospital of Xiamen University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.3, 2013 , pp. 1841-1846 More about this Journal
Abstract
Anti-angiogenic agents have played crucial roles in the treatment of ovarian cancer in recent years, but potential benefits of endostatin have been largely unexplored. The present retrospective study evaluated its efficacy and toxicity with two cohorts of patients with platinum-resistant recurrent ovarian cancer. One cohort received gemcitabine plus endostar (rh-endostatin), and the second cohort received gemcitabine regimen alone, with totals of 31 and 27 patients, respectively. The main endpoints were disease control rate (DCR), PFS, overall survival (OS) and safety. There were statistically significant differences in DCR (70.9% vs. 40.7%; P = 0.02) and PFS (6.3 months vs. 3.2 months, P = 0.001) between the two cohorts. Though the endostar cohort also improved median OS by 2.1 months, there was no statistically significant difference compared with gemcitabine alone cohort in this case (12.5 months vs. 10.4 months, P = 0.201). Treatment was well tolerated for most patients, and toxicity of endostar was negligible. Gemcitabine plus endostar significantly improved the prognosis in patients with platinum-resistant recurrent ovarian cancer, especially in those with malignant effusion. The endostar-containing regimen is recommended in this setting.
Keywords
Salvage therapy; gemcitabine; endostar; epithelial ovarian cancer;
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