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http://dx.doi.org/10.7314/APJCP.2013.14.3.1687

Genetic Screening for Mutations in the Chip Gene in Intracranial Aneurysm Patients of Chinese Han Nationality  

Su, Li (Department of Neurosurgery, the First Affiliated Hospital of Baotou Medical College)
Zhang, Yuan (Department of Pathophysiology, Baotou Medical College)
Zhang, Chun-Yang (Department of Neurosurgery, the First Affiliated Hospital of Baotou Medical College)
Zhang, An-Long (Department of Neurosurgery, the First Affiliated Hospital of Baotou Medical College)
Mei, Xiao-Long (Department of Neurosurgery, the First Affiliated Hospital of Baotou Medical College)
Zhao, Zhi-Jun (Department of Neurosurgery, the First Affiliated Hospital of Baotou Medical College)
Han, Jian-Guo (Department of Neurosurgery, the First Affiliated Hospital of Baotou Medical College)
Zhao, Li-Jun (Department of Neurosurgery, the First Affiliated Hospital of Baotou Medical College)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.3, 2013 , pp. 1687-1689 More about this Journal
Abstract
We performed a case-control study to investigate whether SNPs of CHIP might affect the development of IA in Chinese Han nationality. We believe we are the first to have screened IA patients for mutations in the CHIP gene to determine the association with these variants. The study group comprised 224 Chinese Han nationality patients with at least one intracranial aneurysm and 238 unrelated healthy Han nationality controls. Genomic DNA was isolated from blood leukocytes. The entire coding regions of CHIP were genotyped by PCR amplification and DNA sequencing. Differences in genotype and allele frequencies between patients and controls were tested by the chi-square method. Genotype and allele frequencies of the SNP rs116166850 was demonstrated to be in Hardy-Weinberg equilibrium. No significant difference in genotype or allele frequencies between case and control groups was detected at the SNP. Our data do not support the hypothesis of a major role for the CHIP gene in IA development in the Chinese Han population.
Keywords
CHIP; genetic screening; intracranial aneurysms; subarachnoid hemorrhage;
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