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http://dx.doi.org/10.7314/APJCP.2013.14.2.969

Lack of Impact of Age on Acute Side Effects and Tolerance of Curative Radiation Therapy  

Yucel, Birsen (Cumhuriyet University School of Medicine)
Okur, Yillar (Department of Radiation Oncology, Ankara Numune Education and Research Hospital)
Akkas, Ebru Atasever (Department of Radiation Oncology, Sivas Numune State Hospital)
Eren, Mehmet Fuat (Cumhuriyet University School of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.2, 2013 , pp. 969-975 More about this Journal
Abstract
Aim: The aim of this study was to determine the impact of age on the occurrence, severity, and timing of acute side effects related to radiotherapy. Materials and Methods: We analysed the data of 423 patients. Results: Of the patients, 295 (70%) were under the age of 65 (group 1) and 128 (30%) were over the age of 65 (group 2). The frequencies of radiotherapy-induced side effects were 89% in group 1 and 87% in group 2 (p=0.286). The mean times to occurrence were $2.5{\pm}0.1$ weeks in group 1 and $2.2{\pm}0.1$ weeks in group 2 (p=0.013). Treatment was ended in 2% of patients in group 1 and 6% of those in group 2 (p=0.062). Treatment interruption was identified in 18% of patients in group 1 and 23% in group 2 (p=0.142). Changes in performance status were greater in older patients (p=0.013). There were no significant differences according to the frequency or severity of side effects, except skin and genitourinary complications, between the groups. Conclusions: Early normal tissue reactions were not higher in older versus younger patients, though there was a tendency towards an earlier appearance.
Keywords
Radiotherapy; side effects; age; cancer;
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