Browse > Article
http://dx.doi.org/10.7314/APJCP.2013.14.2.859

Comparison of Different Screening Methods in Estimating the Prevalence of Precancer and Cancer Amongst Male Inmates of a Jail in Maharashtra, India  

Chaudhari, Amit (Department of Public Health Dentistry, Kothiwal Dental College)
Hegde-Shetiya, Sahana (Department of Public Health Dentistry, Dr. D. Y. Patil Vidyapeeth's Dr. D.Y. Patil Dental College)
Shirahatti, Ravi (Department of Public Health Dentistry, Sinhgad Dental College)
Agrawal, Deepti (Department of Public Health Dentistry, Dr. D. Y. Patil Vidyapeeth's Dr. D.Y. Patil Dental College)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.2, 2013 , pp. 859-864 More about this Journal
Abstract
Aim: To compare the effectiveness of self-examination, clinical examination and screening methods using 1% toluidine blue and Lugol's iodine in estimating the prevalence of lesions at risk of malignancy and oral malignant disease amongst the male inmates of Yerwada Central Jail, Pune. Material and Methods: Study was carried out on male inmates in two phases. In the first phase self-examination and clinical examination was carried out on 2,257 male inmates. 164 suspicious cases were subjected to phase II of the study out of whom, 82 participants were screened with 1% toluidine blue and 2% Lugol's iodine followed by biopsy procedure. Results: Sensitivity and specificity for self-examination with clinical examination was 92.2% and 96.6% respectively. Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) and positive (+LR) and negative likelihood ratio (-LR) for Toluidine Blue were 88.1%, 66.6% 97.1%, 30%, 2.63 and 0.17 respectively while for Lugol's Iodine they were 94.7%, 83.8%, 98.6%, 55.5%, 5.67 and 0.06 respectively. Conclusions: Prevalence of lesions at risk of malignancy and oral malignant disease by self-examination was 7.8% and by clinical examination was 6.3%. Self-examination is an effective tool in early detection of oral cancer. Use of Lugol's iodine as a screening tool for oral lesions is highly effective in inmate populations.
Keywords
Lesions at risk of malignancy; oral cancer; mouth self-examination; toluidine blue; Lugol's iodine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Mathew B, Sankaranarayanan R, Wesley R, et al (1995). Evaluation of mouth self-examination in the control of oral cancer. Bri J Cancer, 71, 397-9.   DOI
2 Mathew P, Elting L, Cooksley C, et al (2005). Cancer in an incarcerated population. Cancer, 104, 2197-204.   DOI   ScienceOn
3 Myers EN (1970). The toluidine blue test in lesions of the oral cavity. Cancer J Clin, 20, 134-9.   DOI   ScienceOn
4 Nagaraju K, Prasad S, Ashok L (2010). Diagnostic efficiency of toluidine blue with Lugol's iodine in oral premalignant and malignant lesions. Ind J Dent Res, 21, 218-2.   DOI   ScienceOn
5 Niebel HH, Chomet B (1964). In vivo staining test for delineation of oral intraepithelial neoplastic change: preliminary report. J Am Dent Assoc, 68, 801-6.   DOI
6 Oh ES, Laskin DM (2007). Efficacy of the ViziLite system in the identification of oral lesions. J Oral Maxillofac Surg, 65, 424-6.   DOI   ScienceOn
7 Oliver RJ, Sloan P, Pemberton MN (2004). Oral biopsies: methods and applications. Bri Dental J, 196, 239-44.
8 Onofre MA, Sposto MR, Navarro CM (1995). Assessment of the blue toluidine stain in oral lesions with suspicious of malignancy. J Dent Res, 74, 782.
9 Onofre MP, Sposto MR, Navarro CM, et al (2001). Reliability of toluidine blue application in the detection of oral epithelial dysplasia and in situ and invasive squamous cell carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 91, 535-40.   DOI   ScienceOn
10 Peterson PK (2005). Strengthening the prevention of oral cancer: the WHO perspective. Community Dent Oral Epidemiol, 33, 397-9.   DOI   ScienceOn
11 Sankaranarayanan R, Ramadas K, Muwonge R, et al (2005). Effect of screening on oral cancer mortality in Kerala, India: a cluster randomised controlled trial. Lancet, 365, 1927-33.   DOI   ScienceOn
12 Scott SE, Rizvi K, Grunfeld EA, et al (2010). Pilot study to estimate the accuracy of mouth self-examination in an at-risk group. Head and Neck, 32, 1393-401.   DOI   ScienceOn
13 Shiozaki H, Tahara H, Kobayashi K, et al (1990). Endoscopic screening of early esophageal cancer with the Lugol dye method in patients with head and neck cancer. Cancer, 66, 2068-71.   DOI   ScienceOn
14 Silverman S Jr, Migliorati C, Barbosa J (1984). Toluidine blue staining in the detection of oral precancerous and malignant lesions. Oral Surg, 57, 379-82.   DOI   ScienceOn
15 Subramanian SV, Nandy S, Kelly M, et al (2004). Patterns and distribution of tobacco consumption in India: cross sectional multilevel evidence from the 1998-9 national family health survey. Bri Med J, 328, 821-7.
16 Vahidy NA, Zaidi SHM, Jafarey NA (1972). Toluidine blue test for detection of carcinoma of the oral cavity: an evaluation. J Surg Oncol, 4, 434-8.   DOI   ScienceOn
17 Walsh T, Tickle M, Milsom K, et al (2008). An investigation of the nature of research into dental health in prisons: a systematic review. B Dent J, 204, 683-9.   DOI   ScienceOn
18 Warnakulasuriya KAAS, Johnson NW (1996). Sensitivity and specificity of $OraScan^{(R)}$ toluidine blue mouthrinse in the detection of oral cancer and precancer, J Oral Pathol Med, 25, 97-103.   DOI   ScienceOn
19 Dahiya M, Croucher R (2010). Male prisoner tobacco use and oral cancer knowledge: a case study of a local prison in India. Int Dent J, 60, 135-13.
20 Bhoopathi V, Kabani S, Mascarenhas AK(2009). Low positive predictive value of the oral brush biopsy in detecting dysplastic oral lesions. Cancer, 115, 1036-40.   DOI   ScienceOn
21 Dawsey SM, Fleischer DE, Wang GQ, et al (1998). Mucosal iodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in Linxian, China. Cancer, 83, 220-32   DOI   ScienceOn
22 Epstein JB, Oakley C, Millner A, et al (1997). The utility of toluidine blue application as a diagnostic aid in patients previously treated for upper oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 83, 537-47.   DOI   ScienceOn
23 Epstein JB, Scully C, Spinelli JJ (1992). Toluidine blue and Lugol's iodine application in the assessment of oral malignant disease and lesions at risk of malignancy. J Oral Pathol Med, 21, 160-3.   DOI   ScienceOn
24 Kujan O, Glenny AM, Oliver R, et al (2009). Screening programmes for the early detection and prevention of oral cancer. Aus Dental J, 54, 170-2.   DOI   ScienceOn
25 Evans EC, Brotherstone H, Miles A, et al(2005). Gender differences in early detection of cancer. Jmhg, 2, 209-17.
26 Hacihasanoglua R, Gozum S (2008). The effect of training on the knowledge levels and beliefs regarding breast self-examination on women attending a public education centre. Eur J Oncol Nur, 12, 58-64.   DOI   ScienceOn
27 Kujan O, Glenny AM, Duxbury AJ, et al (2005). Evaluation of screening strategies for improving oral cancer mortality: a cochrane systematic review. J Dent Edu, 69, 255-66.
28 Kuruvilla J (2004). Utilizing dental colleges for the eradication of oral cancer in India. Ind J Dent Res, 19, 349-55.
29 Leston JS, Dios PD (2010). Diagnostic clinical aids in oral cancer. Oral Oncol, 46, 418-22.   DOI   ScienceOn
30 Lingen MW, Kalmar JR, Karrison T, et al (2008). Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncol, 44, 10-22.   DOI   ScienceOn
31 Mashberg A (1983). Final evaluation of tolonium chloride rinse for screening of high-risk patients with asymptomatic squamous carcinoma. J Am Dent Assoc, 106, 319-23.   DOI
32 Mashberg A (1980). Reevaluation of toluidine blue application as a diagnostic adjunct in the detection of asymptomatic oral squamous carcinoma: A continuing prospective study of oral cancer III, Cancer, 46, 758-63.   DOI   ScienceOn
33 Mashberg A (1981). Tolonium (toluidine blue) rinse: a screening method for recognition of squamous carcinoma-continuing prospective study of oral cancer IV. JAMA, 245, 2408-10.   DOI   ScienceOn