Browse > Article
http://dx.doi.org/10.7314/APJCP.2013.14.2.665

Possible Relation between the NOS3 Gene GLU298ASP Polymorphism and Bladder Cancer in Turkey  

Verim, Levent (Haydarpasa Numune Training Hospital, Urology Department)
Toptas, Bahar (The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University)
Ozkan, Nazli Ezgi (The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University)
Cacina, Canan (The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University)
Turan, Saime (The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University)
Korkmaz, Gurbet (The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University)
Yaylim, Ilhan (The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.2, 2013 , pp. 665-668 More about this Journal
Abstract
Endothelial nitric oxide synthase (eNOS), encoded by the NOS3 gene, has been suggested to play an important role in uncontrolled cell growth in several cancer types. The objective of this study was to evaluate the role of the NOS3 Glu298Asp polymorphism in bladder cancer susceptibility in a Turkish population. We determined the genotypes of 66 bladder cancer cases and 88 healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. A significant association for NOS3 Glu298Asp heterozygotes genotypes and T allele were found between healthy controls and bladder cancer, respectively (p<0.001: p=0.002). There were no significant associations between any genotypes and the stage, grade, and histological type of bladder cancer. Our study suggested an increased risk role of NOS3 GT genotype in bladder cancer susceptibility in our Turkish population.
Keywords
DNA; cancer; nitric oxide; bladder cancer; polymorphism;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Ahsan A, Norboo T, Baig MA, Qadar Pasha MA (2005). Simultaneous selection of the wild-type genotypes of the G894T and 4B/4A polymorphisms of NOS3 associate with high-altitude adaptation. Ann Hum Genet, 69, 260-7.   DOI
2 Amasyali AS, Kucukgergin C, Erdem S, et al (2012). Nitric oxide synthase (eNOS4a/b) gene polymorphism is associated with tumor recurrence and progression in superficial bladder cancer cases. J Urol, 188, 2398-403.   DOI   ScienceOn
3 Arikan S, Cacina C, Guler E, et al (2012). The effects of NOS3 Glu298Asp variant on colorectal cancer risk and progression in Turkish population. Mol Biol Rep, 39, 3245-9.   DOI   ScienceOn
4 Chien YH, Bau DT, Jan KY (2004). Nitric oxide inhibits DNA-adduct excision in nucleotide excision repair. Free Radic Biol Med, 36, 1011-7.   DOI   ScienceOn
5 Choi BM, Pae HO, Jang SI, et al (2002). Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator. J Biochem Mol Biol, 35, 116-26.   DOI   ScienceOn
6 Choi JY, Barlow WE, Albain KS, et al (2009). Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial. Clin Cancer Res, 15, 5258-66.   DOI   ScienceOn
7 Colombo MG, Andreassi MG, Paradossi U, et al (2002). Evidence for association of a common variant of the endothelial nitric oxide synthase gene (Glu298-->Asp polymorphism) to the presence, extent, and severity of coronary artery disease. Heart, 87, 525-8.   DOI
8 Demirel F, Cakan M, Yalcinkaya F, Topcuoglu M, Altug U (2008). The association between personal habits and bladder cancer in Turkey. Int Urol Nephrol, 40, 643-7.   DOI
9 Dhar A, Brindley JM, Stark C, et al (2003). Nitric oxide does not mediate but inhibits transformation and tumor phenotype. Mol Cancer Ther, 2, 1285-93.
10 Dosenko VIe, Zahorii VIu, Khaitovych NV, Hordok OA, Moibenko OO (2005). Allelic polymorphism of endothelial NO-synthase gene and its functional activity. Fiziol Zh, 51, 39-45.
11 Fabbri F, Brigliadori G, Ulivi P, et al (2005). Pro-apoptotic effect of a nitric oxide-donating NSAID, NCX 4040, on bladder carcinoma cells. Apoptosis, 10, 1095-103.   DOI
12 Gao J, Liu X, Rigas B (2005). Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress. Proc Natl Acad Sci USA, 102, 17207-12.   DOI   ScienceOn
13 Giovino GA, Mirza SA, Samet JM, et al (2012). Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys. Lancet, 380, 668-79.   DOI   ScienceOn
14 Hefler LA, Ludwig E, Lampe D, et al (2002). Polymorphisms of the endothelial nitric oxide synthase gene in ovarian cancer. Gynecol Oncol, 86, 134-7.   DOI   ScienceOn
15 Kario K, Pickering TG, Umeda Y, et al (2003). Morning surge in blood pressure as a predictor of silent and clinical cerebrovasculardisease in elderly hypertensives: a prospective study. Circulation, 107, 1401-6.   DOI   ScienceOn
16 Hong CC, Ambrosone CB, Ahn J, et al (2007). Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev, 16, 1784-94.   DOI   ScienceOn
17 Jadeski LC, Chakraborty C, Lala PK (2003). Nitric oxide-mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen-activated protein kinase. Int J Cancer, 106, 496-504.   DOI   ScienceOn
18 Kario K, Pickering TG, Matsuo T, et al (2001). Stroke prognosis andabnormal nocturnal blood pressure falls in older hypertensives. Hypertension, 38, 852-7.   DOI   ScienceOn
19 Kong L, Dunn GD, Keefer LK, Korthuis RJ (1996). Nitric oxide reduces tumor cell adhesion to isolated rat postcapillary venules. Clin Exp Metastasis, 14, 335-43.   DOI
20 Lamblin N, Cuilleret FJ, Helbecque N, et al (2005). A common variant of endothelial nitric oxide synthase (Glu298Asp) is associated with collateral development in patients with chronic coronary occlusions. BMC Cardiovasc Disord, 15, 5-27.
21 Lee KM, Choi JY, Lee JE, et al (2007). Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement. Breast Cancer Res Treat, 106, 433-8.   DOI
22 Lee KM, Kang D, Park SK, et al (2009). Nitric oxide synthase gene polymorphisms and prostate cancer risk. Carcinogenesis, 30, 621-5.   DOI   ScienceOn
23 Muller JE, Stone PH, Turi ZG, et al (1985). Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med, 313, 1315-22.   DOI   ScienceOn
24 Lu J, Wei Q, Bondy ML, et al (2006). Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years. Cancer, 107, 2245-53.   DOI   ScienceOn
25 Miller SA, Dykes DD, Polesky HS (1998). Simples salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res, 16, 1215.
26 Miyamoto Y, Saito Y, Kajiyama N (1998). Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension, 32, 3-8   DOI   ScienceOn
27 Ozturk O, Kagnici OF, Ozturk T, et al (2009). 192R allele of paraoxanase 1 (PON1) gene as a new marker for susceptibility to bladder cancer. Anticancer Res, 29, 4041-6.
28 Ryk C, Wiklund NP, Nyberg T, de Verdier PJ (2011). Polymorphisms in nitric-oxide synthase 3 may influence the risk of urinary-bladder cancer. Nitric Oxide, 25, 338-43.   DOI   ScienceOn
29 Serrano NC, Paez C, Correa PA, Anaya JM (2004). Endothelial nitric oxide synthase gene polymorphism is associated with systemic lupus erythematosus. J Rheumatol, 31, 2163-8.
30 Shochina M, Fellig Y, Sughayer M, et al (2001). Nitric oxide synthase immune reactivity in human bladder carcinoma. Mol Pathol, 54, 248-52.   DOI
31 Tecder UM, Karabulut HG, Gumus-Akay G, et al (2010) Endothelial nitric oxide synthase gene polymorphism in gastric cancer. Turk J Gastroenterol, 21, 338-44.
32 Terrazzino S, La Mattina P, Masini L, et al (2012). Common variants of eNOS and XRCC1 genes may predict acute skin toxicity in breast cancer patients receiving radiotherapy after breast conserving surgery. Radiother Oncol, 103, 199-205.   DOI   ScienceOn
33 Wang L, Shi GG, Yao JC, et al (2005). Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer. Gastric Cancer, 8, 18-28.   DOI
34 Tesauro M, Thompson WC, Rogliani P, et al (2000). Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci USA, 97, 2832-5.   DOI   ScienceOn
35 The Health Ministry of Republic of Turkey (2004). The final report of national disease responsibility and the Project of cost effectiveness, Ankara. http://www.tusak.saglik.gov.tr/pdf/nbd/raporlar/hastalikyukuTR.pdf
36 Venturelli E, Villa C, Fenoglio C, et al.(2009). The NOS3 G894T (Glu298Asp) polymorphism is a risk factor for frontotemporal lobar degeneration. Eur J Neurol, 16, 37-42.   DOI   ScienceOn
37 Willich SN, Goldberg RJ, Maclure M, et al (1992). Increased onset of sudden cardiac death in the first three hours after awakening. Am J Cardiol, 70, 65-8.   DOI   ScienceOn
38 Yang J, Ambrosone CB, Hong CC, et al (2007). Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer. Carcinogenesis, 28, 1247-53.   DOI   ScienceOn