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http://dx.doi.org/10.7314/APJCP.2013.14.2.1093

Association between p53 Gene Variants and Oral Cancer Susceptibility in Population from Gujarat, West India  

Patel, Kinjal R. (Biochemistry Research Division)
Vajaria, Bhairavi N. (Biochemistry Research Division)
Begum, Rasheedunnisa (Department of Biochemistry, The M. S. University of Baroda)
Shah, Franky D. (Biochemistry Research Division)
Patel, Jayendra B. (Biochemistry Research Division)
Shukla, Shilin N. (The Gujarat Cancer and Research Institute)
Patel, Prabhudas S. (Biochemistry Research Division)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.2, 2013 , pp. 1093-1100 More about this Journal
Abstract
Background: p53 gene variants i.e. 16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies. Therefore, the present study evaluated the role of these p53 polymorphisms in oral cancer susceptibility in a population from Gujarat, West India. Method: Genotype frequencies at the three p53 loci in 110 controls and 79 oral cancer cases were determined by the PCR-RFLP method. Results: Heterozygous individuals at exon 4 showed protection from developing oral cancer. Homozygous wild and heterozygous individuals at intron 3 and those heterozygous at exon 4 in combination appeared to be at lowered risk. Furthermore, carriers of the 16 bp duplication allele at intron 3, proline allele at exon 4 and G allele at intron 6 were protected from oral cancer development. Conclusion: p53 polymorphisms, especially Arg72Pro in exon 4 could significantly modify the risk of oral cancer development in Gujarat, West Indian population.
Keywords
Arg72Pro polymorphism; genetic susceptibility; oral cancer; p53 polymorphisms; PCR-RFLP;
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