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http://dx.doi.org/10.7314/APJCP.2013.14.1.399

The miR-146a rs2910164 G > C Polymorphism and Susceptibility to Digestive Cancer in Chinese  

Wu, Dong (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Wang, Fan (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Dai, Wei-Qi (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine)
He, Lei (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Lu, Jie (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Xu, Ling (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Guo, Chuan-Yong (Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.1, 2013 , pp. 399-403 More about this Journal
Abstract
Background: Several studies have reported the role of the miR-146a rs2910164 G > C polymorphism as a susceptibility factor for several digestive cancers. However, the results have been controversial. Therefore, we conducted the present meta-analysis to obtain the most reliable estimate of the association. Methods: PubMed, Embase and Web of Science databases were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between miR-146a rs2910164 G > C polymorphism and digestive cancer risk. A total of four eligible studies including 3,447 cases and 5,041 controls based on the search criteria were included. Results: We observed that miR-146a rs2910164 G > C polymorphism was not significantly correlated with digestive cancer risks when all studies were pooled into the meta-analysis. While we found that miR-146a rs2910164 polymorphism was not associated with gastric cancer, it was significantly linked with hepatocellular cancer risk (the homozygote codominant model: OR = 1.40, 95% CI = 1.04-1.87). In the stratified analysis by ethnicity, significant associations were observed in Chinese population for the allele contrast model (OR = 1.25; 95% CI = 1.12-1.38), for the homozygote codominant model (OR = 1.62; 95% CI = 1.28-2.04), and for the recessive model (OR = 1.38; 95% CI = 1.16-1.64). However, studies with Asian groups presented no significant association for all genetic models. Conclusions: This meta-analysis suggests that the miR-146a rs2910164 G > C polymorphism is a low-penetrant risk factor for digestive cancers in Chinese.
Keywords
MicroRNAs; genetic polymorphisms; mutation; risk; meta-analysis; Chinese;
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