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http://dx.doi.org/10.7314/APJCP.2013.14.11.6601

Associations Between Three Common MicroRNA Polymorphisms and Hepatocellular Carcinoma Risk in Chinese  

Hao, Yu-Xia (Department of Infection, The First of Hospital of Shanxi Medical University)
Wang, Jun-Ping (Shanxi Provincial People's Hospital)
Zhao, Long-Feng (Department of Infection, The First of Hospital of Shanxi Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.11, 2013 , pp. 6601-6604 More about this Journal
Abstract
Aim: Associations between polymorphisms in miR-146aG>C, miR-196a2C>T and miR-499A>G and risk of HCC, and interaction with HBV infection in a Chinese population, were the target of the present research. Methods: The duplex polymerase-chain-reaction with confronting-two-pair primers (PCR-RFLP) was performed to determine the genotypes of the miR-146aG>C, miR-196a2C>T and miR-499A>G genotypes. Associations of polymorphisms with the risk of HCC were estimated by conditional logistic regression analysis. Results: Drinking, family history of cancer, HBsAg and HCV were risk factors for HCC. Multivariate regression analyses showed that subjects carrying the miR-196a2 CC genotype had significantly increased risk of HCC, with an adjusted OR (95% CI) of 2.18 (1.23-3.80). In addition, cases carrying the miR-196a2 C allele had a 1.64-fold increase in the risk for HCC (95%CI=1.03-2.49). The miR-196a2 CT and TT genotypes greatly significantly increased the risk of HCC in subjects with HBV infection, with adjusted ORs (95% CI) of 2.02 (1.12-3.68) and 2.69 (1.28-5.71), respectively. Conclusion: Our results demonstrate that miR-196a2 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection.
Keywords
MicroRNA; polymorphisms; hepatocellular carcinoma; HBV; risk;
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1 Bartel DP (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116, 281-97.   DOI   ScienceOn
2 Davila JA, Morgan RO, Shaib Y, et al (2004). Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology, 127, 1372-80.   DOI   ScienceOn
3 El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557-76.   DOI   ScienceOn
4 Esquela-Kerscher A, Slack FJ (2006). Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer, 6, 259-69.   DOI   ScienceOn
5 Han Y, Pu R, Han X, et al (2013). Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk. PLoS One, 8, e58564.   DOI
6 Hu M, Zhao L, Hu S, Yang J (2013). The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population. PLoS One, 8, e57012.   DOI
7 Huang S, He X (2011). The role of microRNAs in liver cancer progression. Br J Cancer, 104, 235-40.   DOI   ScienceOn
8 International Agency for Research on Cancer (2008). Globocan 2008 in China. http://globocan.iarc.fr/factsheet.asp.
9 Jang MJ, Kim JW, Min KT, et al (2011). Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer. Exp Ther Med, 2, 1127-32.   DOI
10 Kim WH, Min KT, Jeon YJ, et al (2012). Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population. Gene, 504, 92-7.   DOI   ScienceOn
11 Li XD, Li ZG, Song XX, Liu CF (2010). A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis. Pathology, 42, 669-73.   DOI   ScienceOn
12 Lim LP, Lau NC, Garrett-Engele P, et al (2005). Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature, 433, 769-73.   DOI   ScienceOn
13 Linhares JJ, Azevedo M Jr, Siufi AA, et al (2012). Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer. BMC Med Genet, 13, 119.   DOI
14 Ladeiro Y, Couchy G, Balabaud C, et al (2008). MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology, 47, 1955-63.   DOI   ScienceOn
15 Li W, Xie L, He X, et al (2008). Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma. Int J Cancer, 123, 1616-22.   DOI   ScienceOn
16 Masaki T (2009). MicroRNA and hepatocellular carcinoma. Hepatol Res, 39,751-2.   DOI   ScienceOn
17 Pavlakis E, Papaconstantinou I, Gazouli M, et al (2013). MicroRNA gene polymorphisms in pancreatic cancer. Pancreatology, 13, 273-8.   DOI   ScienceOn
18 Vinci S, Gelmini S, Pratesi N, et al (2011). Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers. Clin Chem Lab Med, 49, 2073-80.
19 Qi P, Dou TH, Geng L, et al (2010). Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection. Hum Immunol, 71, 621-6.   DOI   ScienceOn
20 Valencia-Sanchez MA, Liu J, Hannon GJ, et al (2006). Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev, 20, 515-24.   DOI   ScienceOn
21 Wang F, Sun GP, Zou YF, et al (2013). Quantitative assessment of the association between miR-196a2 rs11614913 polymorphism and gastrointestinal cancer risk. Mol Biol Rep, 40, 109-16.   DOI   ScienceOn
22 Wang PY, Gao ZH, Jiang ZH, et al (2013). The Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a and miR-499 with Breast Cancer Susceptibility. PLoS One, 8, e70656.   DOI
23 Wei J, Zheng L, Liu S, et al (2013). MiR-196a2 rs11614913 T>C polymorphism and risk of esophageal cancer in a Chinese population. Hum Immunol, 74, 1199-205.   DOI   ScienceOn
24 Wilfred BR, Wang WX, Nelson PT (2007). Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab, 91, 209-17.   DOI   ScienceOn
25 Wu M, Jolicoeur N, Li Z, et al (2008). Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs. Carcinogenesis, 29, 1710-6.   DOI   ScienceOn
26 Yu MC, Yuan JM (2004). Environmental factors and risk for hepatocellular carcinoma. Gastroenterology, 127, S72-8.   DOI   ScienceOn
27 Wu XJ, Mi YY, Yang H, et al (2013). Association of the hsa-mir-499 (rs3746444) Polymorphisms with Gastric Cancer Risk in the Chinese Population. Onkologie, 36, 573-6.   DOI   ScienceOn
28 Xiang Y, Fan S, Cao J, et al (2012). Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population. Mol Biol Rep, 39, 7019-23.   DOI   ScienceOn
29 Yuan Z, Zeng X, Yang D, Wang W, Liu Z (2013). Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. PLoS One, 8, e61047.   DOI
30 Zhan X, Wu W, Han B, et al (2012). Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population. J Clin Lab Anal, 26, 441-6.   DOI   ScienceOn
31 Zhang YG, Shi JX, Song CH, et al (2013). Association of mir-499 and mir-149 polymorphisms with cancer risk in the Chinese population: evidence from published studies. Asian Pac J Cancer Prev, 14, 2337-42.   DOI   ScienceOn
32 Zheng SQ, Li YX, Zhang Y, Li X, Tang H (2011). MiR-101 regulates HSV-1 replication by targeting ATP5B. Antiviral Res, 89, 219-26.   DOI   ScienceOn