Anti-proliferative Effects of Atractylis lancea (Thunb.) DC. via Down-regulation of the c-myc/hTERT/Telomerase Pathway in Hep-G2 Cells |
Guo, Wei-Qiang
(School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology)
Li, Liang-Zhi (School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology) He, Zhuo-Yang (School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology) Zhang, Qi (School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology) Liu, Jia (School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology) Hu, Cui-Ying (School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology) Qin, Fen-Ju (School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology) Wang, Tao-Yun (School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology) |
1 | Mahavorasirikul M, Viyanant V, Chaijaroenkul W, et al (2010). Cytotoxic activity of Thai medicinal plants against human cholangiocinoma, laryngeal and hepatocarcinoma cells in vitro. BMC Complement Altern Med, doi, 10. 1186/ 1472-6882-10-55. DOI ScienceOn |
2 | Mok TS, Yeo W, Johnson PJ, et al (2007). A double blind placebo-controlled randomized study of Chinese herbal medicine as complementary therapy for reduction of chemotherapy induced toxicity. Ann Oncol, 18, 768-74. |
3 | Moyzis RK, Buckingham JM, Cram LS, et al (1988). A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA, 85, 6622-6. DOI ScienceOn |
4 | Murnane JP (2010). Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res, 70, 4255-9. DOI |
5 | Ohyashiki K, Ohyashiko JH, Yahata N, et al (1997). Detection of telomerase activity and its clinical application. Rinsho Byori, 45, 1133-41. |
6 | Ouellette MM, Wright WE, Shay JW (2011). Targeting telomerase expressiong cancer cells. J Cell Mol Med, 15, 1433-42. DOI ScienceOn |
7 | Park SE, Yoo HS, Jin CY, et al (2009). Induction of apoptosis and inhibition of tolemerase activity in human lung carcinoma cells by the water extract of cordyceps militaris. Food Chem Toxicol, 47, 1667-75. DOI ScienceOn |
8 | Peng HS, Yuan QJ, Li QQ, et al (2012). Molecular systematics of genus atractylodes (compositae, Cardueae): Evidence from internal transcribed spacer (ITS) and trnL-F sequences. Int J Mol Sci, 13, 14623-33. DOI ScienceOn |
9 | Shay JW, Wright WE (2011). Role of telomeres and telomerase in cancer. Semin Cancer Biol, 21, 349-54. DOI ScienceOn |
10 | Cerni C (2000). Telomeres, telomerase, and myc. An update. Mutat Res, 462, 31-47. DOI ScienceOn |
11 | Dang CV (2012). MYC on the path to cancer. Cell, 149, 22-35. DOI ScienceOn |
12 | Donate LE, Blasco MA (2011). Telomeres in cancer and ageing. Phli Trans Soc B, 366, 76-84. DOI ScienceOn |
13 | Fabregat I (2009). Dysregulation of apoptosis in hepatocellular carcinoma cells. World J Gastroenterol, 15, 513-20. DOI |
14 | Feo F, Frau M, Pascale RM (2008). Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis. World J Gastroenterol, 14, 6601-15. DOI |
15 | Henriksson M, Luscher B (1996). Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv Cancer Res, 68, 109-82. DOI |
16 | Huang ST, Pang JH, Yang RC (2010). Anti-cancer effects of phyllanthus urinaria and relevant mechanisms. Chang Guang Med J, 33, 477-87. |
17 | Kang TH, Bang JY, Kim MH, et al (2011). Atractylenolide , a sesquiterpenoid, induces apoptosis in human lung carcinoma A549 cells via mitochondria mediated death pathway. Food Chem Toxicol, 49,514-9. DOI ScienceOn |
18 | Liu Y, Chen W, Zeng M, et al (2012). Pharmacodynamics of water extracts from Atractylodes lancea before and after processing. Zhongguo Zhong Yao Za Zhi, 37, 2276-9. |
19 | Ward PS, Thompson CB (2012). Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell, 21, 297-308. DOI ScienceOn |
20 | Sprouse AA, Steding CE, Herbert BS (2012). Pharmaceutical regualtion of telomerase and its clinical potential. J Cell Mol Med, 16, 1-7. DOI ScienceOn |
21 | Wu KJ, Grandori C, Amacker M, et al (1999). Direct activation of TERT transcription by c-myc. Nat Genet, 21, 220-4. DOI ScienceOn |
22 | Ye Y, Wang H, Chu JH, et al (2011). Atractylenolide Ⅱ induces G1 cell-cycle arrest and apoptosis in B16 melanoma cells. J Ethnopharmacol, 136, 279-82. DOI ScienceOn |
23 | Zhao M, Wang Q, Ouyang Z, et al (2013). Selective fraction of Atractylodes lancea (Thunb.) DC. And its growth inhibitory effect on human gastric cancer cells. Cytotechnology, doi:10.1007/s/10616-013-9559-1. |
24 | Zhao Y, Jian W, Gao W, et al (2013). RNAi silencing of c-myc inhibits cell migration, invasion, and proliferation in HepG2 human hepatocellular carcinoma cell line: c-myc silencing in hepatocellular carcinoma cell. Cancer Cell Int, 13, 23-8. DOI ScienceOn |
![]() |