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http://dx.doi.org/10.7314/APJCP.2013.14.10.5637

Involvement of EBV-encoded BART-miRNAs and Dysregulated Cellular miRNAs in Nasopharyngeal Carcinoma Genesis  

Xie, Yuan-Jie (Cancer Research Institute, University of South China)
Long, Zhi-Feng (Micromorphology Laboratory Center, University of South China)
He, Xiu-Sheng (Cancer Research Institute, University of South China)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.10, 2013 , pp. 5637-5644 More about this Journal
Abstract
The definite molecular mechanisms underlying the genesis of nasopharyngeal carcinomas (NPCs) remain to be completely elucidated. miRNAs are small non-coding RNAs which are implicated in cell proliferation, apoptosis, and even carcinogenesis through negatively regulating gene expression post-transcriptionally. EBV was the first human virus found to express miRNAs. EBV-encoded BART-miRNAs and dysregulated cellular miRNAs are involved in carcinogenesis of NPC by interfering in the expression of viral and host cell genes related to immune responses and perturbing signal pathways of proliferation, apoptosis, invasion, metastasis and even radio-chemo-therapy sensitivity. Additional studies on the roles of EBV-encoded miRNAs and cellular miRNAs will provide new insights concerning the complicated gene regulated network and shed light on novel strategies for the diagnosis, therapy and prognosis of NPC.
Keywords
EBV-encoded BART-miRNAs; carcinogenesis; miRNAs; nasopharyngeal carcinoma;
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1 Li JX, Lu TX, Huang Y, Han F (2012). Clinical characteristics of recurrent nasopharyngeal carcinoma in high-incidence area. Sci World J, doi: 10.1100/2012/719754   DOI
2 LIANG BJ, LI XP, LU J, et al (2012). [Effects of enhancer of zeste homolog (EZH2) downregulation on the proliferation and invasion of nasopharyngeal carcinoma cell and the possible mechanisms]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 47, 298-304.
3 Liu N, Chen NY, Cui RX, et al (2012). Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol, 13, 633-41.   DOI   ScienceOn
4 Liu X, Lv XB, Wang XP, et al (2012). MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene. Cell Cycle, 11, 2495-506.   DOI
5 Lo AK, To KF, Lo KW, et al (2007). Modulation of LMP1 protein expression by EBV-encoded microRNAs. Proc Natl Acad Sci U S A, 104,16164-9.   DOI   ScienceOn
6 Luo Z, Zhang L, Li Z, et al (2012). An in silico analysis of dynamic changes in microRNA expression profiles in stepwise development of nasopharyngeal carcinoma. BMC Med Genomics, doi: 10.1186/1755-8794-5-3.   DOI   ScienceOn
7 Lu J, He ML, Wang L, et al (2011). MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. Cancer Res, 71, 225-33.   DOI   ScienceOn
8 Lung RW, Wang X, Tong JH, et al (2012). A single nucleotide polymorphism in microRNA-146a is associated with the risk for nasopharyngeal carcinoma. Mol Carcinog, doi:10.1002/mc.21937.   DOI   ScienceOn
9 Yu H, Lu J, Zuo L, et al (2012). Epstein-Barr virus downregulates microRNA 203 through the oncoprotein latent membrane protein 1: a contribution to increased tumor incidence in epithelial cells. J Virol, 86, 3088-99.   DOI
10 Yu L, Lu J, Zhang B, et al (2013). miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2. Oncol Lett, 5, 1223-8.
11 Yu X, Zhen Y, Yang H, et al (2013). Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma. Cell Death Dis, 4, e634.   DOI
12 Zhang LY, Ho-Fun LV, Wong AM, et al (2013). MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. Carcinogenesis, 34, 454-63.   DOI   ScienceOn
13 Zhang JX, Qian D, Wang FW, et al (2013). MicroRNA-29c enhances the sensitivities of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy. Cancer Lett, 329, 91-8.   DOI   ScienceOn
14 Zhang L, Deng T, Li X, et al (2010). microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis, 31, 559-66.   DOI   ScienceOn
15 Zhong W, He B, Quan T, et al (2013). [Expression of miR-143 in nasopharyngeal carcinoma cell lines and its effect on cell adhesion ability]. Nan Fang Yi Ke Da Xue Xue Bao, 33, 582-5.
16 Zhou Y, Zheng J, Deng J, et al (2013). A sequence polymorphism in miRNA-608 predicts recurrence after radiotherapy of nasopharyngeal carcinoma. Cancer Res, 73, 5151-62.   DOI   ScienceOn
17 Zhu JY, Pfuhl T, Motsch N, et al (2009). Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas. J Virol, 83, 3333-41.   DOI   ScienceOn
18 Chen HC, Chen GH, Chen YH, et al (2009). MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer, 100, 1002-11.   DOI   ScienceOn
19 Chen L, Tang Y, Wang J, Yan Z, Xu R (2013). miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4. Biochem Biophys Res Commun, 435, 745-50.   DOI   ScienceOn
20 Cosmopoulos K, Pegtel M, Hawkins J, et al (2009). Comprehensive profiling of Epstein-Barr virus microRNAs in nasopharyngeal carcinoma. J Virol, 83, 2357-67.   DOI   ScienceOn
21 Chen SJ, Chen GH, Chen YH, et al (2010). Characterization of Epstein-Barr virus miRNAome in nasopharyngeal carcinoma by deep sequencing. PLoS One, 5, doi:pii: e12745. 10.1371/journal.pone.0012745.   DOI
22 Cho WC (2007). Nasopharyngeal carcinoma: molecular biomarker discovery and progress. Mol Cancer, 6, doi:10.1186/1476-4598-6-1   DOI   ScienceOn
23 Luo Z, Dai Y, Zhang L, et al (2013). miR-18a promotes malignant progression by impairing microRNA biogenesis in nasopharyngeal carcinoma. Carcinogenesis, 34, 415-25.   DOI   ScienceOn
24 Marquitz AR, Mathur A, Nam CS, Raab-Traub N (2011). The Epstein-Barr Virus BART microRNAs target the proapoptotic protein Bim. Virology, 412, 392-400.   DOI   ScienceOn
25 Marquitz AR, Raab-Traub N (2012). The role of miRNAs and EBV BARTs in NPC. Semin Cancer Biol, 22,166-72.   DOI   ScienceOn
26 Mei J, Bachoo R, Zhang CL (2011). MicroRNA-146a inhibits glioma development by targeting Notch1. Mol Cell Biol, 31,3584-92.   DOI   ScienceOn
27 Nachmani D, Stern-Ginossar N, Sarid R, Mandelboim O (2009). Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells. Cell Host Microbe, 5, 376-85.   DOI   ScienceOn
28 Ng WT, Lee MC, Hung WM, et al (2011). Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys, 79, 420-8.   DOI   ScienceOn
29 Pan J, Hu H, Zhou Z, et al (2010). Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells. Oncol Rep, 24, 105-12.
30 Oh SY, Ju Y, Park H (2009). A highly effective and long-lasting inhibition of miRNAs with PNA-based antisense oligonucleotides. Mol Cells, 28,341-5.   과학기술학회마을   DOI   ScienceOn
31 Ohshima K, Inoue K, Fujiwara A, et al (2010). Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. PLoS One, 5, e13247.   DOI
32 Alajez NM, Lenarduzzi M, Ito E, et al (2011). MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res, 71, 2381-91.   DOI
33 Cameron JE, Yin Q, Fewell C, et al (2008). Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol, 82, 1946-58.   DOI   ScienceOn
34 Alajez NM, Shi W, Hui AB, et al (2010). Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98. Cell Death Dis, 1, e85.   DOI
35 Barth S, Meister G, Grasser FA (2011). EBV-encoded miRNAs. Biochim Biophys Acta, 1809, 631-40.   DOI   ScienceOn
36 Cai X, Schafer A, Lu S, et al (2006). Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog, 2, e23.   DOI
37 Cao JY, Mansouri S, Frappier L (2012). Changes in the nasopharyngeal carcinoma nuclear proteome induced by the EBNA1 protein of Epstein-Barr virus reveal potential roles for EBNA1 in metastasis and oxidative stress responses. J Virol, 86, 382-94.   DOI
38 Cao SM, Simons MJ, Qian CN (2011). The prevalence and prevention of nasopharyngeal carcinoma in China. Chin J Cancer, 30, 114-9.   DOI
39 Chan JY, Gao W, Ho WK, Wei WI, Wong TS (2012). Overexpression of Epstein-Barr virus-encoded microRNA-BART7 in undifferentiated nasopharyngeal carcinoma. Anticancer Res, 32, 3201-10.
40 Deng M, Tang H, Zhou Y, et al (2011). miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma. J Cell Sci, 124, 2997-3005.   DOI   ScienceOn
41 Deng M, Ye Q, Qin Z, et al (2013). miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal carcinoma. Tumour Biol, 34, 1793-800.   DOI   ScienceOn
42 Dolken L, Malterer G, Erhard F, et al (2010). Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay. Cell Host Microbe, 7, 324-34.   DOI   ScienceOn
43 Du ZM, Hu LF, Wang HY, et al (2011). Upregulation of MiR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A. PLoS One, 6, e19137.   DOI   ScienceOn
44 Guo X, Liao Q, Chen P, et al (2012). The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma. J Cancer Res Clin Oncol, 138, 49-56.   DOI   ScienceOn
45 Edwards RH, Marquitz AR, Raab-Traub N (2008). Epstein-Barr virus BART microRNAs are produced from a large intron prior to splicing. J Virol, 82, 9094-106.   DOI   ScienceOn
46 Farazi TA, Hoell JI, Morozov P, Tuschl T (2013). MicroRNAs in human cancer. Adv Exp Med Biol, 774, 1-20.   DOI   ScienceOn
47 Garzon R, Marcucci G, Croce CM (2010). Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov, 9, 775-89.   DOI   ScienceOn
48 Polesel J, Serraino D, Negri E, et al (2013). Consumption of fruit, vegetables, and other food groups and the risk of nasopharyngeal carcinoma. Cancer Causes Control, 24, 1157-65.   DOI   ScienceOn
49 Qu C, Liang Z, Huang J, et al (2012). MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. Cell Cycle, 11, 785-96.   DOI
50 Qu H, Xu W, Huang Y, Yang S (2011). Circulating miRNAs: promising biomarkers of human cancer. Asian Pac J Cancer Prev, 12, 1117-25.
51 Sengupta S, den Boon JA, Chen IH, et al (2008). MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc Natl Acad Sci U S A, 105, 5874-8.   DOI   ScienceOn
52 Shair KH, Schnegg CI, Raab-Traub N (2008). EBV latent membrane protein 1 effects on plakoglobin, cell growth, and migration. Cancer Res, 68, 6997-7005.   DOI   ScienceOn
53 Wijnhoven BP, Hussey DJ, Watson DI, et al (2010). MicroRNA profiling of Barrett's oesophagus and oesophageal adenocarcinoma. Br J Surg, 97, 853-61.   DOI   ScienceOn
54 Twu CW, Wang WY, Liang WM, et al (2007). Comparison of the prognostic impact of serum anti-EBV antibody and plasma EBV DNA assays in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys, 67, 130-7.   DOI   ScienceOn
55 Wang W, Le W, Cho DY, Hwang PH, Upadhyay D (2011). Novel effects of statins in enhancing efficacy of chemotherapy in vitro in nasopharyngeal carcinoma. Int Forum Allergy Rhinol, 1, 284-9.   DOI   ScienceOn
56 Webb N, Connolly G, Tellam J, Yap AS, Khanna R (2008). Epstein-Barr virus associated modulation of Wnt pathway is not dependent on latent membrane protein-1. PLoS One, 3, e3254.   DOI   ScienceOn
57 He ML, Luo MX, Lin MC, Kung HF (2012). MicroRNAs: potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma. Biochim Biophys Acta, 1825, 1-10.
58 Hennessey PT, Sanford T, Choudhary A, et al (2012). Serum microRNA biomarkers for detection of non-small cell lung cancer. PLoS One, 7, e32307.   DOI
59 Hui AB, Bruce JP, Alajez NM, et al (2011). Significance of dysregulated metadherin and microRNA-375 in head and neck cancer. Clin Cancer Res, 17, 7539-50.   DOI   ScienceOn
60 Jr Meckes DG, Shair KH, Marquitz AR, et al (2010). Human tumor virus utilizes exosomes for intercellular communication. Proc Natl Acad Sci U S A, 107, 20370-5.   DOI   ScienceOn
61 Kim DN, Chae HS, Oh ST, et al (2007). Expression of viral microRNAs in Epstein-Barr virus-associated gastric carcinoma. J Virol, 81, 1033-6.   DOI   ScienceOn
62 Kim DN, Lee SK (2012). Biogenesis of Epstein-Barr virus microRNAs. Mol Cell Biochem, 365, 203-10.   DOI   ScienceOn
63 Li T, Chen JX, Fu XP, et al (2011). microRNA expression profiling of nasopharyngeal carcinoma. Oncol Rep, 25, 1353-63.
64 Li G, Liu Y, Su Z, et al (2013). MicroRNA-324-3p regulates nasopharyngeal carcinoma radioresistance by directly targeting WNT2B. Eur J Cancer, doi: 10.1016/j.ejca.2013.03.001.   DOI   ScienceOn
65 Li G, Wu Z, Peng Y, Liu X, et al (2010). MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells. Cancer Lett, 299, 29-36.   DOI   ScienceOn
66 Wong AM, Kong KL, Tsang JW, Kwong DL, Guan XY (2012). Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs. Cancer, 118, 698-710.   DOI   ScienceOn
67 Wu CD, Kuo YS, Wu HC, Lin CT (2011). MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells. J Biomed Sci, doi: 10.1186/1423-0127-18-80.   DOI
68 Wu H, Mo YY (2009). Targeting miR-205 in breast cancer. Expert Opin Ther Targets, 13, 1439-48.   DOI   ScienceOn
69 Xia H, Cheung WK, Sze J, et al (2010). miR-200a regulates epithelial-mesenchymal to stem-like transition via ZEB2 and beta-catenin signaling. J Biol Chem, 285, 36995-7004.   DOI   ScienceOn
70 Yi C, Wang Q, Wang L, et al (2012). MiR-663, a microRNA targeting p21 (WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma. Oncogene, 31, 4421-33.   DOI   ScienceOn
71 Xia H, Ng SS, Jiang S, et al (2010). miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion. Biochem Biophys Res Commun, 391, 535-41.   DOI   ScienceOn
72 Xia XM, Jin WY, Shi RZ, Zhang YF, Chen J (2010). Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer. Oncol Lett, 1, 1045-1047.
73 Xu X, Yang H, Huo X (2004). [Expression and significance of PTEN in nasopharyngeal carcinoma]. Lin Chuang Er Bi Yan Hou Ke Za Zhi, 18, 658-9.
74 Yoshizaki T, Ito M, Murono S, et al (2012). Current understanding and management of nasopharyngeal carcinoma. Auris Nasus Larynx, 39, 137-44.   DOI   ScienceOn
75 Akao Y, Nakagawa Y, Naoe T (2006). let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull, 29, 903-6.   DOI   ScienceOn
76 Choy EY, Siu KL, Kok KH, et al (2008). An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival. J Exp Med, 205, 2551-60.   DOI   ScienceOn
77 Dawson CW, Port RJ, Young LS (2012). The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC). Semin Cancer Biol, 22, 144-53.   DOI   ScienceOn
78 Lo AK, Dawson CW, Jin DY, Lo KW (2012). The pathological roles of BART miRNAs in nasopharyngeal carcinoma. J Pathol, 227, 392-403.   DOI   ScienceOn
79 Zeng X, Xiang J, Wu M, et al (2012). Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinoma. PLoS One, 7, e46367.   DOI
80 Kok KH, Lei T, Jin DY (2010). Identification and validation of the cellular targets of virus-encoded microRNAs. Methods Mol Biol, 667, 319-26.   DOI   ScienceOn
81 Paik JH, Jang JY, Jeon YK, et al (2011). MicroRNA-146a downregulates NFkappaB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma. Clin Cancer Res, 17, 4761-71.   DOI   ScienceOn
82 Wong TS, Man OY, Tsang CM, et al (2011). MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression. J Cancer Res Clin Oncol, 137, 415-22.   DOI
83 You S, Zhang F, Meng F, et al (2011). EBV-encoded LMP1 increases nuclear beta-catenin accumulation and its transcriptional activity in nasopharyngeal carcinoma. Tumour Biol, 32, 623-30.   DOI   ScienceOn