Characterization and Resistance Mechanisms of A 5-fluorouracil-resistant Hepatocellular Carcinoma Cell Line |
Gu, Wei
(Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University)
Fang, Fan-Fu (Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University) Li, Bai (Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University) Cheng, Bin-Bin (Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University) Ling, Chang-Quan (Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University) |
1 | Baguley BC (2010). Multidrug resistance in cancer. Methods Mol Biol, 596, 1-14. DOI |
2 | Bruix J, Sherman M; Practice Guidelines Committee, American Association for the Study of Liver Diseases (2005). Management of hepatocellular carcinoma. Hepatology, 42, 1208-36. DOI ScienceOn |
3 | Chen R, Zhu D, Ye X, et al (1980). Establishment of three human liver carcinoma cell lines and some of their biological characteristics in vitro. Sci Sin, 23, 236-47. |
4 | Dai ZQ, Wang R, Ling SK, et al (2007). Simulated microgravity inhibits the proliferation and osteogenesis of rat bone marrow mesenchymal stem cells. Cell Prolif, 40, 671-84. DOI ScienceOn |
5 | Durand RE, Olive PL (1981). Flow cytometry studies of intracellular adriamycin in single cells in vitro. Cancer Res, 41(9 Pt 1), 3489-94. |
6 | El-Serag HB (2011). Hepatocellular carcinoma. N Engl J Med, 365, 1118-27. DOI ScienceOn |
7 | Ferlay J, Shin HR, Bray F, et al (2010). GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer. Available from: http://globocan.iarc.fr |
8 | Frustaci S, Bearz A, Basso B, et al (2003). Efficacy of oxaliplatin and 5-fluorouracil in hepatocarcinoma (HCC). Proc Am Soc Clin Oncol, 22, (abstr 1346). |
9 | Green SK, Francia G, Isidoro C, Kerbel RS (2004). Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro. Mol Cancer Ther, 3, 149-59. |
10 | Guglielmi A, Aschele C, Grossi F, et al (1996). Alternating bolus and continuous infusion 5-fluorouracil: a strategy to overcome resistance to this fluoropyrimidine in advanced colorectal cancer patients. Cytotechnology, 19, 215-9. DOI |
11 | Han KQ, Huang G, Gu W, et al (2007). Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. World J Gastroenterol, 13, 3374-9. |
12 | Huai-Yun H, Secrest DT, Mark KS, et al (1998). Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells. Biochem Biophys Res Commun, 243, 816-20. DOI ScienceOn |
13 | Jianmin Z, Hongfang W, Meifu F (2002). Resistance of multicellular aggregates to pharmorubicin observed in human hepatocarcinoma cells. Braz J Med Biol Res, 35, 255-60. DOI |
14 | Jin J, Huang M, Wei HL, Liu GT (2002). Mechanism of 5-fluorouracil required resistance in human hepatocellular carcinoma cell line Bel(7402). World J Gastroenterol, 8, 1029-34. |
15 | Li B, Ye T, Zhao L, et al (2006). Effects of multidrug resistance, antisense RNA on the chemosensitivity of hepatocellular carcinoma cells. Hepatobiliary Pancreat Dis Int, 5, 552-9. |
16 | Marin JJ, Romero MR, Briz O (2010). Molecular bases of liver cancer refractoriness to pharmacological treatment. Curr Med Chem, 17, 709-40. DOI |
17 | Li G, Chen X, Wang Q, et al (2007). The roles of four multi-drug resistance proteins in hepatocellular carcinoma multidrug resistance. J Huazhong Univ Sci Technolog Med Sci, 27, 173-5. DOI |
18 | Li YX, Lin ZB, Tan HR (2004). Wild type p53 increased chemosensitivity of drug-resistant human hepatocellular carcinoma Bel7402/5-FU cells. Acta Pharmacol Sin, 25, 76-82. |
19 | Livraghi T, Makisalo H, Line PD (2011). Treatment options in hepatocellular carcinoma today. Scand J Surg, 100, 22-9. |
20 | Meta-analysis Group In Cancer (1998). Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol, 16, 301-8. |
21 | Petriz J, Garcia-Lopez J (1997). Flow cytometric analysis of P-glycoprotein function using rhodamine 123. Leukemia, 11, 1124-30. DOI |
22 | Qin S, Thongprasert S, Lim HY, et al (2010). Oxaliplatin + 5-fluorouracil/leucovorin (FOLFOX4) in advanced HCC: updated efficacy results of the EACH trial. Ann Oncol, 21(Suppl 8), 826P. DOI |
23 | Ryu SH, Chung YH (2010). How to overcome multidrug resistance in chemotherapy for advanced hepatocellular carcinoma. Liver Int, 30, 496-8. DOI |
24 | Shaffer LG, Tommerup N, ed (2005). ISCN 2005: An International System for Human Cytogenetic Nomenclature. S. Karger, Basel, Switzerland. |
25 | Sun Z, Zhao Z, Li G, et al (2010). Relevance of two genes in the multidrug resistance of hepatocellular carcinoma: in vivo and clinical studies. Tumori, 96, 90-6. |
26 | Wrzesinski SH, Taddei TH, Strazzabosco M (2011). Systemic therapy in hepatocellular carcinoma. Clin Liver Dis, 15, 423-41. DOI |
27 | Tong SW, Yang YX, Hu HD, et al (2012). Proteomic investigation of 5-fluorouracil resistance in a human hepatocellular carcinoma cell line. J Cell Biochem, 113, 1671-80. |
28 | Uchibori K, Kasamatsu A, Sunaga M, et al (2012). Establishment and characterization of two 5-fluorouracil-resistant hepatocellular carcinoma cell lines. Int J Oncol, 40, 1005-10. |
29 | Wilson TR, Johnston PG, Longley DB (2009). Anti-apoptotic mechanisms of drug resistance in cancer. Curr Cancer Drug Targets, 9, 307-19. DOI |
30 | Yan F, Wang XM, Liu ZC, et al (2010). JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells. Hepatobiliary Pancreat Dis Int, 9, 287-95. |
31 | Yang JX, Luo Y, Qiu HM, Tang WX (2009). Characterization and resistance mechanisms of cisplatin-resistant human hepatocellular carcinoma cell line. Saudi Med J, 30, 35-40. |
32 | Yunis JJ (1981). New chromosome techniques in the study of human neoplasia. Hum Pathol, 12, 540-9. DOI |
33 | Zhai BJ, Shao ZY, Zhao CL, et al (2006). Development and characterization of multidrug resistant human hepatocarcinoma cell line in nude mice. World J Gastroenterol, 12, 6614-9. |
34 | Zhou J, Cheng SC, Luo D, Xie Y (2001). Study of multi-drug resistant mechanisms in a taxol-resistant hepatocellular carcinoma QGY-TR 50 cell line. Biochem Biophys Res Commun, 280, 1237-42. DOI |
35 | Zhou Y, Ling XL, Li SW, et al (2010). Establishment of a human hepatoma multidrug resistant cell line in vitro. World J Gastroenterol, 16, 2291-7. DOI |
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