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http://dx.doi.org/10.7314/APJCP.2012.13.9.4409

Estimation of Superoxide Dismutase and Glutathione Peroxidase in Oral Submucous Fibrosis, Oral Leukoplakia and Oral Cancer - A Comparative Study  

Gurudath, Shubha (Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre)
Ganapathy, K.S. (Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre)
D., Sujatha (Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre)
Pai, Anuradha (Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre)
Ballal, Sushmini (Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre)
Asha, M.L. (Oral Medicine and Radiology Sri Hasanamba Dental College)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.9, 2012 , pp. 4409-4412 More about this Journal
Abstract
Present study was undertaken to estimate and compare erythrocyte superoxide dismutase (E-SOD) and Glutathione peroxidase (GPx) levels in oral submucous fibrosis, oral leukoplakia and oral cancer patients and age/sex matched healthy subjects, 25 in each group. Statistically significant (P<0.001) decrease in E-SOD and GPx levels were observed in OSF, oral leukoplakia and oral cancer groups as compared to the control group. Oral leukoplakia group showed lower levels in comparison with OSF (P>0.05). Oral cancer group had the lowest levels amongst the study groups. Imbalance in antioxidant enzyme status may be considered as one of the factors responsible for the pathogenesis of cancer and may serve as a potential biomarker and therapeutic target to reduce the malignant transformation in oral premalignant lesions/conditions.
Keywords
Oral submucous fibrosis; oral leukoplakia; oral cancer; superoxide dismutase; glutathione peroxidase;
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