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http://dx.doi.org/10.7314/APJCP.2012.13.9.4403

Glutathione-S-Transferase T1 Polymorphism is Associated with Esophageal Cancer Risk in Chinese Han Population  

Weng, Yuan (Department of Thoracic and Cardiovascular Surgery, No.4 people's hospital of Wuxi City)
Fei, Bojian (Department of Surgical Oncology, No.4 people's hospital of Wuxi City)
He, Ping (Department of Surgical Oncology, No.4 people's hospital of Wuxi City)
Cai, Ming (Department of Thoracic and Cardiovascular Surgery, No.4 people's hospital of Wuxi City)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.9, 2012 , pp. 4403-4407 More about this Journal
Abstract
Background: Glutathione-S-Transferase T1 (GSTT1) gene has been shown to be involved in the development of esophageal cancer. However, the results have been inconsistent. In this study, the authors performed a meta-analysis to clarify the association between GSTT1 polymorphism and esophageal cancer risk among Chinese Han population. Methods: Published literature from PubMed, the China National Knowledge Infrastructure and Wanfang Data were searched. Pooled odds ratio (OR) and 95% confidence interval (95%CI) was calculated using a fixed- or random-effects model. Results: Eleven studies with a total of 2779 individuals were included in the meta-analysis. The results showed that GSTT1 null genotype was significantly associated with esophageal cancer risk in Chinese (OR = 1.31, 95%CI 1.12 to 1.53, p = 0.001). Further sensitivity analyses confirmed the significant association. The cumulative meta-analysis showed a trend of an obvious association between GSTT1 null genotype and esophageal cancer risk as information accumulated by year. Conclusions: This meta-analysis suggests a significant association of GSTT1 null genotype with esophageal cancer risk in the Chinese Han population.
Keywords
Glutathione-S-transferase T1; esophageal cancer; meta-analysis; Chinese;
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1 Thallinger CM, Raderer M, Hejna M (2011). Esophageal cancer: a critical evaluation of systemic second-line therapy. J Clin Oncol, 29, 4709-14.   DOI
2 Wang B, Huang G, Wang D, et al (2010). Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis. J Hepatol, 53, 508-18.   DOI   ScienceOn
3 Wang LD, Zheng S, Liu B, et al (2003). CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China. World J Gastroenterol, 9, 1394-7.
4 Yang L, Parkin DM, Li L, et al (2003). Time trends in cancer mortality in China: 1987-1999. Int J Cancer, 106, 771-83.   DOI
5 Yi LH, Pu YP, Song YH, et al (2005). Polymorphisms of susceptible genes for esophageal cancer risk in Huaian population in Jiangsu province. Zhong Liu, 25, 357-61.
6 Zhang LW, Yi L, Wu M, et al (2009). Study on relations between genetic polymorphisms in CYP2C19, GSTT1 and risk of Kazakh's esophageal cancer in Xinjiang. J Pract Oncol, 24, 232-6.
7 Zhang ZJ, Hao K, Shi R, et al (2011). Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis. Am J Epidemiol, 173, 847-57.   DOI
8 Zhang ZY, Jin XY, Wu R, et al (2012). Meta-analysis of the association between GSTM1 and GSTT1 gene polymorphisms and cervical cancer. Asian Pac J Cancer Prev, 13, 815-9.   DOI
9 Zhuo WL, Zhang YS, Wang Y, et al (2009). Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses. Arch Med Res, 40, 169-79.   DOI
10 Cochran WG (1954). The combination of estimates from different experiments. Biometrics, 10, 101-29.   DOI
11 Deng J, Guo R, Yue H, et al (2008). A case-control study of the polymorphism of Phase I and Phase II metabolic genes and esophageal carcinoma susceptibility. Shiyong Xin Nao Xue Guan Bing Za Zhi, 16, 16-7.
12 DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88.   DOI
13 Dong LM, Potter JD, White E, et al (2008). Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA, 299, 2423-36.   DOI   ScienceOn
14 Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34.   DOI
15 Fang Y, Xiao F, An Z, et al (2011). Systematic review on the relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and esophageal squamous cell carcinoma. Asian Pac J Cancer Prev, 12, 1861-6.
16 Gao CM, Takezaki T, Wu JZ, et al (2002). Glutathione-Stransferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control study of a high-incidence area in Jiangsu Province, China. Cancer Lett, 188, 95-102.   DOI
17 Gao P, Qian Y, Ye X, et al (2012). Study of CYP1A1, GSTM1, GSTT1 polymorphisms and susceptibility on esophageal carcinoma in Ninxia Hui nationality. Ningxia Medical Journal, 34, 196-9.
18 Hayes JD, Strange RC (2000). Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology, 61, 154-66.   DOI   ScienceOn
19 Hayes JD, Flanagan JU, Jowsey IR (2005). Glutathione transferases. Annu Rev Pharmacol Toxicol, 45, 51-88.   DOI
20 Hiyama T, Yoshihara M, Tanaka S, et al (2007). Genetic polymorphisms and esophageal cancer risk. Int J Cancer, 121, 1643-58.   DOI
21 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
22 Ji R, Wu J, Zhou Y, et al (2010). Relationship between CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and susceptibility of esophageal cancer in Wuwei, Gansu province. J Lanzhou Univ (Medical Sciences), 36, 29-34.
23 Kumar V, Murthy AK, Suresh KP (2011). Glutathione S-transferase M1 and T1 status and the risk of laryngeal cancer: a meta-analysis. Asian Pac J Cancer Prev, 12, 2221-6.
24 Lao-Sirieix P, Caldas C, Fitzgerald RC (2010). Genetic predisposition to gastro-oesophageal cancer. Curr Opin Genet Dev, 20, 210-7.   DOI
25 Lau J, Antman EM, Jimenez-Silva J, et al (1992). Cumulative meta-analysis of therapeutic trials for myocardial infarction. N Engl J Med, 327, 248-54.   DOI
26 Lin DX, Tang YM, Peng Q, et al (1998). Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1. Cancer Epidemiol Biomarkers Prev, 7, 1013-8.
27 Liu R, Yin L, Pu Y, et al (2010). Functional alterations in the glutathione S-transferase family associated with enhanced occurrence of esophageal carcinoma in China. J Toxicol Environ Health A, 73, 471-82.   DOI
28 Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
29 Mao WM, Zheng WH, Ling ZQ (2011). Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev, 12, 2461-6.
30 Oakley A (2011). Glutathione transferases: a structural perspective. Drug Metab Rev, 43, 138-51.   DOI
31 Pearson WR, Vorachek WR, Xu SJ, et al (1993). Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. Am J Hum Genet, 53, 220-33.
32 Pera M, Manterola C, Vidal O, et al (2005). Epidemiology of esophageal adenocarcinoma. J Surg Oncol, 92, 151-9.   DOI   ScienceOn
33 Qiu LX, Yuan H, Yu KD, et al (2010). Glutathione S-transferase M1 polymorphism and breast cancer susceptibility: a metaanalysis involving 46,281 subjects. Breast Cancer Res Treat, 121, 703-8.   DOI
34 Qiu LX, Wang K, Lv FF, et al (2011). GSTM1 null allele is a risk factor for gastric cancer development in Asians. Cytokine, 55, 122-5.   DOI
35 Raza H (2011). Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease. FEBS J, 278, 4243-51.   DOI
36 Roth MJ, Abnet CC, Johnson LL, et al (2004). Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes. Cancer Causes Control, 15, 1077-83.   DOI
37 Strange RC, Spiteri MA, Ramachandran S, et al (2001). Glutathione-S-transferase family of enzymes. Mutat Res, 482, 21-6.   DOI
38 Tan W, Song N, Wang GQ, et al (2000). Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China. Cancer Epidemiol Biomarkers Prev, 9, 551-6.