Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines |
Al-Douh, Mohammed Hadi
(Chemistry Department, Faculty of Science, Hadhramout University of Science and Technology (HUST))
Sahib, Hayder B. (Pharmacology Department, College of Pharmacy, Karbala University) Osman, Hasnah (School of Chemical Sciences, Universiti Sains Malaysia (USM)) Hamid, Shafida Abd (Kulliyyah of Science, International Islamic University Malaysia (IIUM)) Salhimi, Salizawati M. (School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM)) |
1 | Smith MBK, Hose BM, Howkins A, et al (2003). Molecular modeling calculations of HIV-1 reverse transcriptase nonnucleoside inhibitors: Correlation of binding energy with biological activity for novel 2-aryl-substituted benzimidazole analogues. J Med Chem, 46, 1940-7. DOI |
2 | Sondhi SM, Singh N, Kumar A, Lozach O, Meijer L (2006). Synthesis, anti-inflammatory, analgesic and kinase (CDK- 1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff's bases. Bioorg Med Chem, 14, 3758-65. DOI |
3 | Soto SE, Molina RV, Crespo FA, et al (2006). Relaxant activity of 2-(substituted phenyl)-1H-benzimidazoles on isolated rat aortic rings Design and synthesis of 5-nitro derivatives. Life Science, 79, 430-5. DOI |
4 | Starcevic K, Kralj M, Ester K, et al (2007). Synthesis, antiviral and antitumor activity of 2-substituted-5-amidinobenzimidazoles. Bioorg Med Chem, 15, 4419-42. DOI ScienceOn |
5 | Timmegowda NR, Swamy SN, Kumar CSA, et al (2008). Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Bioorg Med Chem Lett, 18, 432-5. DOI |
6 | Townsend LB, Revankav GR(1970). Benzimidazole nucleosides, nucleotides, and related derivatives. Chem Rev, 70, 389-438. DOI |
7 | Trivedi R, De SK, Gibbs RA (2006). A convenient one-pot synthesis of 2-substituted benzimidazoles. J Mol Catal A Chem, 245, 8-11. DOI |
8 | Vazquez GN, Vilchis MMR, Mulia LY, et al (2006). Synthesis and antiprotozoal activity of some 2-(trifluoromethyl)-1Hbenzimidazole bioisosteres. Eur J Med Chem, 41, 135-41. DOI |
9 | Al-Douh MH (2010). Synthesis, Characterization and Anti- Proliferation Study of Some Benzimidazole Derivatives. PhD Thesis. Universiti Sains Malaysia (USM), Malaysia, ISNB: 978-3-8443-3294-0, LAP LAMBERT Academic Publishing GmbH & Co. KG, Dudweiler Landstr, 99, 66123 Saarbrucken, Germany. |
10 | Al-Douh MH, Hamid SA, Osman H, Ng SL, Fun HK (2006). 2-(2-Benzyloxy-3-methoxyphenyl)-1H-benzimidazole. Acta Crystallogr, E, 62, 3954-6. DOI |
11 | Al-Douh MH, Hamid SA, Osman H (2007). 1D and 2D NMR studies of 2-(2-benzyloxy-3-methoxyphenyl)-1Hbenzimidazole. Indo J Chem, 7, 190-6. |
12 | Al-Douh MH, Osman H, Hamid SA, Kia R, Fun HK (2009a). 2-[1-(2-Hydroxy-3-methoxybenzyl)-1H-benzimidazol-2- yl]-6-methoxyphenol monohydrate. Acta Crystallogr E, 65, 913-4. |
13 | Al-Douh MH, Osman H, Hamid SA (2012). Synthesis and characterization of 2-(2-hydroxy-3-methoxyphenyl)-1Hbenzimidazole. Hadh Univ J Nat Appl Sci, 9, 49-64. |
14 | Al-Douh MH, Osman H, Hamid SA, Kia R, Fun HK (2009b). 2-[1-(2-Hydroxy-3-methoxybenzyl)-1H-benzimidazol- 2-yl]-6-methoxyphenol methanol 1.13-solvate. Acta Crystallogr E, 65, 925-6. DOI |
15 | Al-Douh MH, Osman H, Hamid SA (2011a). Synthesis and characterization of N-1-(2-hydroxy-3-methoxybenzyl)-2-(2- hydroxy-3-methoxyphenyl)-1H-benzimidazole. Hadh Univ J Nat Appl Sci, 8, 11-32. |
16 | Al-Douh MH, Osman H, Hamid SA (2011b). Synthesis and characterization of novel benzimidazole: N-1-(2-Benzyloxy- 3-methoxybenzyl)-2-(2-benzyloxy-3-methoxyphenyl)-1Hbenzimidazole. Univ Aden J Nat Appl Sci, 15, In Press. |
17 | Beaulieu PL, Bousquet Y, Gauthier J, et al (2004). Nonnucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: Inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 Cells. J Med Chem, 47, 6884-92. DOI |
18 | Cheng J, Xie J, Luo X (2005). Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives. Bioorg Med Chem Lett, 15, 267-9. DOI |
19 | Craigo W A, LeSueur B W, Skibo E B (1999). Design of highly active analogues of the pyrrolo[1,2-a]benzimidazole antitumor agents. J Med Chem, 42, 3324-33. DOI |
20 | Freshney RI (2000). Culture of animal cells: a manual of basic technique. John Wiley & Sons, Inc., New York, USA, 336. |
21 | Garuti L, Roberti M, Malagoli M, Rossi T, Castelli M (2000). Synthesis and antiproliferative activity of some benzimidazole-4,7-dione derivatives. Bioorg Med Chem Lett, 10, 2193-5. DOI |
22 | Kim JS, Gatto B, Yu C, et al (1996). Substituted 2,5'-bi-1Hbenzimidazoles: Topoisomerase I inhibition and cytotoxicity. J Med Chem, 39, 992-8. DOI |
23 |
Gudmundsson KS, Tidwell J, Lippa N, et al (2000). Synthesis and antiviral evaluation of halogenated |
24 | Hong SY, Chung KH, You HJ, et al (2004). Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation. Bioorg Med Chem Lett, 14, 3563-6. DOI |
25 | Kazimierczuk Z, Andrzejewska M, Kaustova J, Klimesova V (2005). Synthesis and antimycobacterial activity of 2-substituted halogenobenzimidazoles. Eur J Med Chem, 40, 203-8. DOI |
26 | Kim JS, Gatto B, Yu C, et al (1997). Terbenzimidazoles: Influence of 2''-, 4-, and 5-substituents on cytotoxicity and relative potency as Topoisomerase I poisons. J Med Chem, 40, 2818-24. DOI |
27 | Kopanska (n. Zastapilo) K, Najda A, Zebrowska J, et al (2004). Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii. Bioorg Med Chem, 12, 2617-24. DOI ScienceOn |
28 | Kumar D, Jacob MR, Reynolds MB, Kerwin SM (2002). Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1. Bioorg Med Chem, 10, 3997-4004. DOI |
29 | Kus C, Kilcigil GA, Ozbey S, et al (2008). Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol- 2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class. Bioorg Med Chem, 16, 4294-303. DOI |
30 | Li YF, Wang GF, He PL, et al (2006). Synthesis and anti-Hepatitis B virus activity of novel benzimidazole derivatives. J Med Chem, 49, 4790-4. DOI |
31 | Nezhad A K, Rad M N S, Mohabatkar H, Asrari Z, Hemmateenejad B (2005). Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives. Bioorg Med Chem, 13, 1931-8. DOI |
32 | Mavrova AT, Anichina KK, Vuchev DI, et al (2005). Synthesis and antitrichinellosis activity of some 2-substituted-[1,3] thiazolo[3,2-a]benzimidazol-3(2H)-ones. Bioorg Med Chem, 13, 5550-9. DOI ScienceOn |
33 | Mekapati SB, Hansch C (2001). Comparative QSAR studies on bibenzimidazoles and terbenzimidazoles inhibiting Topoisomerase I. Bioorg Med Chem, 9, 2885-93. DOI |
34 | Mosmann TJ (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods, 65, 55-63. DOI ScienceOn |
35 | Ozden S, Atabey D, Yildiz S, Goker H (2005). Synthesis and potent antimicrobial activity of some novel methyl or ethyl 1H-benzimidazole-5-carboxylates derivatives carrying amide or amidine groups. Bioorg Med Chem, 13, 1587-97. DOI ScienceOn |
36 | Rangarajan M, Kim J S, Sim S P, et al (2000). Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles. Bioorg Med Chem, 8, 2591-600. DOI |
37 | Rida SM, El-Hawash SAM, Fahmy HTY, Hazzaa A A, El-Meligy MMM (2006). Synthesis of novel benzofuran and related benzimidazole derivatives for evaluation of in vitro anti- HIV-1, anticancer and antimicrobial activities. Arch Pharm Res, 29, 826-33. 과학기술학회마을 DOI |
38 | Roth T, Morningstar ML, Boyer PL, et al (1997). Synthesis and biological activity of novel nonnucleoside inhibitors of HIV- 1 reverse transcriptase. 2-Aryl-substituted benzimidazoles. J Med Chem, 40, 4199-207. DOI |
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