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http://dx.doi.org/10.7314/APJCP.2012.13.7.3489

Hypermethylation of Suppressor of Cytokine Signaling 1 in Hepatocellular Carcinoma Patients  

Saelee, Pensri (Research Division, National Cancer Institute)
Chuensumran, Ubol (Department of Food Science and Technology, School of Culinary Arts, Suan Dusit Rajabhat University)
Wongkham, Sopit (Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University)
Chariyalertsak, Sunanta (Research Division, National Cancer Institute)
Tiwawech, Danai (Research Division, National Cancer Institute)
Petmitr, Songsak (Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.7, 2012 , pp. 3489-3493 More about this Journal
Abstract
Hepatocellular carcinoma (HCC), the most common primary hepatic tumor, is highly prevalent in the Asia-Pacific region, including Thailand. Many genetic and epigenetic alterations in HCC have been elucidated. The aim of this study was to determine whether aberrant methylation of the suppressor of cytokine signaling 1 gene (SOCS1) occurs in HCCs. Methylation specific-PCR assays were performed to identify the methylation status of SOCS1 in 29 tumors and their corresponding normal liver tissues. An abnormal methylation status was detected in 17 (59%), with a higher prevalence of aberrant SOCS1 methylation significantly correlating with HCC treated without chemotherapy (OR=0.04, 95%CI=0.01-0.31; P=0.001). This study suggests that epigenetic aberrant SOCS1 methylation may be a predictive marker for HCC patients.
Keywords
Hepatocellular carcinoma; DNA methylation; SOCS1; methylation-specific PCR;
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