Association Between Polymorphisms of Dihydrofolate Reductase and Gamma Glutamyl Hydrolase Genes and Toxicity of High Dose Methotrexate in Children with Acute Lymphoblastic Leukemia |
Koomdee, Napatrupron
(Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University)
Hongeng, Suradej (Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University) Apibal, Suntaree (Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University) Pakakasama, Samart (Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University) |
1 | Chen MJ, Shimada T, Moulton AD, et al (1984). The functional human dihydrofolate reductase gene. J Biol Chem, 259, 3933-43. |
2 | Dervieux T, Greenstein N, Kremer J (2006). Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis. Arthritis Rheum, 54, 3095-103. DOI |
3 | Dervieux T, Kremer J, Lein DO, et al (2004). Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis. Pharmacogenetics, 14, 733-9. DOI |
4 | Evans WE, Relling MV (1999). Pharmacogenomics: translating functional genomics into rational therapeutics. Science, 286, 487-91. DOI ScienceOn |
5 | Fotoohi AK, Albertioni F (2008). Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells. Leuk Lymphoma, 49, 410-26. DOI |
6 | Galivan J, Ryan T, Rhee M, et al (1999). Glutamyl hydrolase: properties and pharmacologic impact. Semin Oncol, 26, 33-7. |
7 | Garcia-Bournissen F, Moghrabi A, Krajinovic M (2007). Therapeutic responses in childhood acute lymphoblastic leukemia (ALL) and haplotypes of gamma glutamyl hydrolase (GGH) gene. Leuk Res, 31, 1023-5. DOI |
8 | Genestier L, Paillot R, Quemeneur L, et al (2000). Mechanisms of action of methotrexate. Immunopharmacology, 47, 247-57. DOI |
9 | Gorlick R, Goker E, Trippett T, et al (1996). Intrinsic and acquired resistance to methotrexate in acute leukemia. N Engl J Med, 335, 1041-8. DOI |
10 | Goto Y, Yue L, Yokoi A, et al (2001). A novel single-nucleotide polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene with enhanced expression. Clin Cancer Res, 7, 1952-6. |
11 | Morandi C, Masters JN, Mottes M, et al (1982). Multiple forms of human dihydrofolate reductase messenger RNA. Cloning and expression in Escherichia coli of their DNA coding sequence. J Mol Biol, 156, 583-607. DOI |
12 | Organista-Nava J, Gomez-Gomez Y, Saavedra-Herrera MV, et al (2010). Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico. Leuk Res, 34, 728-32. DOI |
13 | St Jude Children's Research Hospital (2005). St. Jude Total therapy XV: St Jude Children's Research Hospital, National Institutes of Health (NTH). |
14 | Panetta JC, Wall A, Pui CH, et al (2002). Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity. Clin Cancer Res, 8, 2423-9. |
15 | Relling MV, Dervieux T (2001). Pharmacogenetics and cancer therapy. Nat Rev Cancer, 1, 99-108. DOI |
16 | Rhee MS, Lindau-Shepard B, Chave KJ, et al (1998). Characterization of human cellular gamma-glutamyl hydrolase. Mol Pharmacol, 53, 1040-6. |
17 | US Department of Health and Human Services (2009). Common terminology criteria for adverse events version 4.0 (CTCAE): U.S. Department of Health and Human services, National Institutes of Health, National Cancer Institute. |
18 | Yao R, Schneider E, Ryan TJ, et al (1996). Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. Proc Natl Acad Sci USA, 93, 10134-8. DOI |
19 | Yin D, Chave KJ, Macaluso CR, et al (1999). Structural organization of the human gamma-glutamyl hydrolase gene. Gene, 238, 463-70. DOI |
20 | Chabner BA, Allegra CJ, Curt GA, et al (1985). Polyglutamation of methotrexate. Is methotrexate a prodrug? J Clin Invest, 76, 907-12. DOI |
21 | Chave KJ, Auger IE, Galivan J, et al (2000). Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase. J Biol Chem, 275, 40365-70. DOI |
22 | Chave KJ, Ryan TJ, Chmura SE, et al (2003). Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms. Gene, 319, 167-75. DOI |