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http://dx.doi.org/10.7314/APJCP.2012.13.7.3325

Glulathione-S-transferases Gene Polymorphism in Prediction of Gastric Cancer Risk by Smoking and Helicobacter Pylori Infection Status  

Jing, Chen (Department of Cadre Ward, the General Hospital of Chengdu Military Area)
Huang, Zhi-Jie (Department of Nuclear Medicine, the General Hospital of Chengdu Military Area)
Duan, Yu-Qin (Department of Cadre Ward, the General Hospital of Chengdu Military Area)
Wang, Pei-Hong (Gastrointestinal Surgery, the General Hospital of Chengdu Military Area)
Zhang, Ru (Department of Cadre Ward, the General Hospital of Chengdu Military Area)
Luo, Ke-Shu (Department of Pathology, the General Hospital of Chengdu Military Area)
Xiao, Xin-Rong (Department of Cadre Ward, the General Hospital of Chengdu Military Area)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.7, 2012 , pp. 3325-3328 More about this Journal
Abstract
Aim: To evaluate the association of glutathione S-transferases gene polymorphisms with the risk of gastric cancer, with reference to smoking and Helicobacter pylori infection. Methods: We conducted a 1:1 matched case-control study with 410 gastric cancer cases and 410 cancer-free controls. Polymorphisms of GSTM1, GSTT1 and GSTP1 were determined using PCR-CTPP. Results: The GSTM1 and GSTT1 null genotypes were significantly associated with the risk of gastric cancer after adjusting for potential confounding factors (OR=1.68, 95% CI=1.32-2.23 for null GSTM1, OR=1.73; 95% CI=1.24-2.13 for null GSTT1). The combination of null GSTM1 and null GSTT1 conferred an elevated risk (OR=2.54, 95% CI=1.55-3.39). However, no association was found for GSTP1 polymorphism The smoking modified the association of GSTM1 and GSTT1 null genotypes with the risk of gastric cancer. Conclusion: GSTM1 and GSTT1 null genotypes are associated with increased risk of gastric cancer, and smoking modifies the association.
Keywords
GST M1; GST T1; GST P1; polymorphism; gastric cancer; smoking; H. pylori;
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