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http://dx.doi.org/10.7314/APJCP.2012.13.7.3123

Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies  

Wang, Xue-Jun (Department of Emergency, Taihe Hospital, Hubei University of Medicine)
Zeng, Xian-Tao (Department of Stomatology, Taihe Hospital, Hubei University of Medicine)
Duan, Xiao-Li (Department of Digestion, Taihe Hospital, Hubei University of Medicine)
Zeng, Huan-Chao (Department of Emergency, Taihe Hospital, Hubei University of Medicine)
Shen, Rui (Department of Orthopedics, Taihe Hospital, Hubei University of Medicine)
Zhou, Ping (Department of General Surgery, Taihe Hospital, Hubei University of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.7, 2012 , pp. 3123-3127 More about this Journal
Abstract
Objective: Experimental studies have suggested green tea to be a chemopreventive agent for colorectal cancer, and many studies have examined possible associations. However, the conclusions were inconsistent or even contradictory, so we performed a meta-analysis based on published case-control studies to explore if green tea is indeed a protective factor. Methods: PubMed was searched up to May $10^{th}$, 2012 for relevant studies, and references of included studies were manually searched. Finally 13 eligible studies, involving 12,636 cases and 38,419 controls were identified. After data extraction, a meta-analysis was performed using CMA v2 software. Results: The results indicated there may be a weak but not statistically significant reduced risk of colorectal cancer with high dose of green tea intake (OR=0.95, 95% CI:0.81-1.11, p=0.490.69-0.98). This protective effect was also found in all subgroups, except in American and European populations. Sensitivity analysis indicated the result to be robust. Publication bias was not detected by either funnel plot or Egger tests. Conclusion: The results of this meta-analysis indicate a weak lower tendency for colorectal cancer development with green tea consumption, but available epidemiologic data are insufficient to conclude that green tea may protect against colorectal cancer in humans.
Keywords
Green tea; colorectal cancer; colon cancer; rectal cancer; meta-analysis;
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