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http://dx.doi.org/10.7314/APJCP.2012.13.6.2935

Biological Response Modifiers Influence Structure Function Relationship of Hematopoietic Stem and Stromal Cells in a Mouse Model of Leukemia  

Basu, Kaustuv (Department of Anatomy and Cell Biology, McGill University)
Mukherjee, Joydeep (Brain Tumor Research Centre, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Centre, UCSF)
Law, Sujata (Department of Biochemistry & Medical Biotechnology, Stem Cell Research & Application Unit, Calcutta School of Tropical Medicine)
Chaudhuri, Samaresh (Department of Biochemistry & Medical Biotechnology, Stem Cell Research & Application Unit, Calcutta School of Tropical Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.6, 2012 , pp. 2935-2941 More about this Journal
Abstract
Biological response modifiers (BRMs) can alter interactions between the immune system and cancer cells to boost, direct, or restore the body's ability to fight disease. Mice with ethylnitrosourea- (ENU) induced leukemia were here used to monitor the therapeutic efficacy of lipopolysaccaride (LPS), Bacillus Calmette Guerin (BCG) and sheep erythrocytes (SRBC). Flow cytometry based CD34+ positivity analysis, clonogenicity, proliferation and ultrastructure studies using scanning electron microscopy (SEM) of stem cells in ENU induced animals with and without BRMs treatment were performed. BRMs improved the stem-stromal relationship structurally and functionally and might have potential for use as an adjunct in human stem cell therapy.
Keywords
Biological response modifiers; ENU-induced leukemia; LPS; BCG; SRBC;
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