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http://dx.doi.org/10.7314/APJCP.2012.13.6.2853

Quantitative Assessment of the Effects of MMP-2 Polymorphisms on Lung Carcinoma Risk  

Guo, Xiao-Tong (Department of Thoracic Surgery, the 2nd Affiliated Hospital of Harbin Medical University)
Wang, Jun-Feng (Department of Thoracic Surgery, the 3rd Affiliated Hospital of Harbin Medical University)
Zhang, Lin-You (Department of Thoracic Surgery, the 2nd Affiliated Hospital of Harbin Medical University)
Xu, Guang-Quan (Department of Thoracic Surgery, the 2nd Affiliated Hospital of Harbin Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.6, 2012 , pp. 2853-2856 More about this Journal
Abstract
Background: Previous studies assessing associations between matrix metalloproteinase 2 (MMP-2) polymorphisms and lung cancer risk reported conflicting results. A meta-analysis was therefore performed to derive a more precise estimation. Method: Case-control studies assessing associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. Results: 7 studies with a total of 3,189 lung cancer cases and 3,013 controls were finally included into this meta-analysis. Overall, the MMP-2 C735T polymorphism was associated with lung cancer risk under the homozygote model (CC versus TT: OR =1.44, 95% CI = 1.03-2.02, $I^2$ = 0%), while the MMP-2 C1306T polymorphism also associated demonstrated links with all four models (all P values less than 0.05). Subgroup analyses by race suggested obvious associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk in Asians but not in Caucasians. There was no evidence for publication bias. Conclusion: Currently available evidence supports teh conclusion that MMP-2 C735T and C1306T polymorphisms influence susceptibility to lung cancer in Asians.
Keywords
MMP-2; polymorphisms; lung carcinoma; meta-analysis; risk; Asians; Caucasians;
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