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http://dx.doi.org/10.7314/APJCP.2012.13.6.2833

Deregulation of MTDH Gene Expression in Gastric Cancer  

Baygi, Modjtaba Emadi (Department of Genetics, Faculty of Basic Sciences, Research Institute of Biotechnology, Shahrekord University)
Nikpour, Parvaneh (Pediatric Inherited Diseases Research Center, Division of Genetics, Faculty of Medicine, Isfahan University of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.6, 2012 , pp. 2833-2836 More about this Journal
Abstract
Aim: Gastric cancer is the third most frequent cause of cancer mortality worldwide. In Iran, it is one of the leading causes at the national level. Localized at chromosome 8q22, the human MTDH gene has been reported to be over-expressed in a spectrum of malignancies. However, since there is a lack of data concerning with expression in gastric cancer at the transcriptional level, in this study we evaluated MTDH expression in Iranian cases. Methods: Totally, thirty paired gastric samples were examined by quantitative real-time RT-PCR. Results: Although the mRNA expression was significantly elevated in 46.6% of the examined tumor tissues; its expression was low in others (36.6%). Moreover, there was only a marginal statistical difference between the MTDH gene expression of all tumor specimens compared to their paired non-tumor ones and no statistically significant association with the grades and types of the tumors. Conclusion: Taken together, our results demonstrated that expression of MTDH at the transcriptional level may be increased in gastric cancer tissue samples but with considerable heterogeneity. Due to this, it may have the potential to be used as a target for diagnostic/therapeutic purposes only in a subset of patients.
Keywords
Gastric cancer; gene expression; MTDH; AEG-1;
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  • Reference
1 The National Cancer Registry (2008). Fourth national report on cancer incidence and mortality. Ministry of Health and Medical Education, Tehran, Iran.
2 Thirkettle H J, Girling J, Warren A Y, et al (2009). LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res, 15, 3003-13.   DOI
3 Wang Y, Klijn J G, Zhang Y, et al (2005). Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet, 365, 671-9.   DOI
4 Yoo B K, Emdad L, Su Z Z, et al (2009). Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest, 119, 465-77.   DOI
5 Yu C, Chen K, Zheng H, et al (2009). Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis, 30, 894-901.   DOI
6 Jian-bo X, Hui W, Yu-long H, et al (2010). Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol, 28, 455-62.
7 Buckland P R (2004). Allele-specific gene expression differences in humans. Hum Mol Genet, 13, 255-60.   DOI
8 Chen X, Leung S Y, Yuen S T, et al (2003). Variation in gene expression patterns in human gastric cancers. Mol Biol Cell, 14, 3208-15.   DOI   ScienceOn
9 Emdad L, Sarkar D, Su Z Z, et al (2007). Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacol Ther, 114, 155-70.   DOI
10 Emdad L, Sarkar D, Su Z Z, et al (2006). Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res, 66, 1509-16.   DOI
11 Keeney S, Bauer T L (2006). Epidemiology of adenocarcinoma of the esophagogastric junction. Surgical Oncology clinics of North Am, 15, 687-96.   DOI
12 Kikuno N, Shiina H, Urakami S, et al (2007). Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene, 26, 7647-55.   DOI
13 Liu L, Wu J, Ying Z, et al (2010). Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion. Cancer Res, 70, 3750-9.   DOI
14 Kim D H, Mohapatra G, Bollen A, Waldman F M, Feuerstein B G (1995). Chromosomal abnormalities in glioblastoma multiforme tumors and glioma cell lines detected by comparative genomic hybridization. Int J Cancer, 60, 812-9.   DOI
15 Lee S G, Jeon H Y, Su Z Z, et al (2009). Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene, 28, 2476-84.   DOI
16 Lee S G, Su Z Z, Emdad L, Sarkar D, Fisher P B (2006). Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc. Proc Natl Acad Sci USA, 103, 17390-5.   DOI
17 Lee S G, Su Z Z, Emdad L, et al (2008). Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene, 27, 1114-21.   DOI
18 Li J, Yang L, Song L, et al (2009). Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1. Oncogene, 28, 3188-96.   DOI
19 Li J, Zhang N, Song L B, et al (2008). Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res, 14, 3319-26.   DOI
20 Li X, Kong X, Huo Q, et al (2011). Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Sci, 102, 1151-7.   DOI
21 Song L, Li W, Zhang H, et al (2009). Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. J Pathol, 219, 317-26.   DOI
22 Malekzadeh R, Derakhshan M H, Malekzadeh Z (2009). Gastric cancer in Iran: epidemiology and risk factors. Arch Iran Med, 12, 576-83.
23 Mowla S J, Emadi Bayegi M, Ziaee S A, Nikpoor P (2005). Evaluating expression and potential diagnostic and prognostic values of Survivin in bladder tumors: a preliminary report. Urology J, 2, 141-7.
24 Nikpour P, Mowla S J, Jafarnejad S M, Fischer U, Schulz W A (2009). Differential effects of Nucleostemin suppression on cell cycle arrest and apoptosis in the bladder cancer cell lines 5637 and SW1710. Cell Proliferation, 42, 762-9.   DOI
25 Ooi C H, Ivanova T, Wu J, et al (2009). Oncogenic pathway combinations predict clinical prognosis in gastric cancer. PLoS Genet, 5, 1000676.   DOI   ScienceOn
26 Poon T C, Wong N, Lai P B, et al (2006). A tumor progression model for hepatocellular carcinoma: bioinformatic analysis of genomic data. Gastroenterology, 131, 1262-70.   DOI
27 Santarpia M, Magri I, Sanchez-Ronco M, et al (2011). mRNA expression levels and genetic status of genes involved in the EGFR and NF-kappaB pathways in metastatic non-small-cell lung cancer patients. J Transl Med, 9, 163.   DOI
28 Sarkar D, Emdad L, Lee S G, et al (2009). Astrocyte elevated gene-1: far more than just a gene regulated in astrocytes. Cancer Res, 69, 8529-35.   DOI
29 Sarkar D, Park E S, Emdad L, et al (2008). Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res, 68, 1478-84.   DOI
30 Song H, Li C, Li R, Geng J (2010). Prognostic significance of AEG-1 expression in colorectal carcinoma. Int J Colorectal Dis, 25, 1201-9.   DOI