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http://dx.doi.org/10.7314/APJCP.2012.13.6.2699

Expression of Proteasome Activator REGγ in Human Laryngeal Carcinoma and Associations with Tumor Suppressor Proteins  

Li, Li-Ping (Department of Otorhinolaryngology and Translational Neuroscience Center, West China Hospital of Sichuan University)
Cheng, Wei-Bo (Department of Pathology, West China School of Public Health, Sichuan University)
Li, Hong (The Joint Research Center, West China Second University Hospital and University of Hong Kong)
Li, Wen (Department of Otorhinolaryngology and Translational Neuroscience Center, West China Hospital of Sichuan University)
Yang, Hui (Department of Otorhinolaryngology and Translational Neuroscience Center, West China Hospital of Sichuan University)
Wen, Ding-Hou (Department of Otorhinolaryngology and Translational Neuroscience Center, West China Hospital of Sichuan University)
Tang, Yue-Di (Department of Otorhinolaryngology and Translational Neuroscience Center, West China Hospital of Sichuan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.6, 2012 , pp. 2699-2703 More about this Journal
Abstract
The functional significance of the proteasome activator $REG{\gamma}$ in the regulation of cell proliferation and apoptosis has been recognized. However, pathological contributions to tumor development remain to be elucidated. Both oncogenic proteins and tumor suppressors are targeted by $REG{\gamma}$ for proteasomal degradation. It has been proposed that the role of the $REG{\gamma}$ in the pathogenesis of cancer is cell- and context-specific. In this study, we aimed to explore the potential involvement of $REG{\gamma}$ in laryngeal carcinomas, comparing protein expression in tumor and adjacent tissues by immunohistochemical staining and Western blot analysis. We also characterized the correlation between the expression of $REG{\gamma}$ and the previously identified substrates p53 and p21. We showed that $REG{\gamma}$ was abnormally highly expressed in cancer tissues. Statistical analysis revealed that there was a positive relationship between the level of $REG{\gamma}$ and the expression of p53 and p21. Our study suggests that $REG{\gamma}$ overexpression can facilitate the growth of laryngeal cancer cells.
Keywords
$REG{\gamma}$; laryngeal carcinoma; p53; p21;
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