Browse > Article
http://dx.doi.org/10.7314/APJCP.2012.13.5.2057

Variation of Urinary and Serum Trace Elements (Ca, Zn, Cu, Se) in Bladder Carcinoma in China  

Guo, Kun-Feng (Department of Urology, Institute of Urology, The First Affiliated Hospital of China Medical University, China Medical University)
Zhang, Zhe (Department of Urology, Institute of Urology, The First Affiliated Hospital of China Medical University, China Medical University)
Wang, Jun-Yong (Department of Urology, Institute of Urology, The First Affiliated Hospital of China Medical University, China Medical University)
Gao, Sheng-Lin (Department of Urology, Institute of Urology, The First Affiliated Hospital of China Medical University, China Medical University)
Liu, Jiao (Department of Urology, Institute of Urology, The First Affiliated Hospital of China Medical University, China Medical University)
Zhan, Bo (Department of Urology, Institute of Urology, The First Affiliated Hospital of China Medical University, China Medical University)
Chen, Zhi-Peng (Department of Urology, Institute of Urology, The First Affiliated Hospital of China Medical University, China Medical University)
Kong, Chui-Ze (Department of Urology, Institute of Urology, The First Affiliated Hospital of China Medical University, China Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.5, 2012 , pp. 2057-2061 More about this Journal
Abstract
Backgrounds: Deficiency or excess of trace elements can induce body metabolic disorders and cellular growth disturbance, even mutation and cancerization. Since there are few studies of the effect of trace elements in bladder carcinoma in China, the aim of this study was thus to assess variation using a case control approach. Methods: To determine this, 81 patients with bladder carcinoma chosen as a study group and 130 healthy persons chosen as a control group were all assayed for urinary and serum trace elements (calcium [Ca], zinc [Zn], copper [Cu], selenium [Se]) using an atomic absorption spectrophotometer, and the results were analyzed by independent sample t tests. The correlative factors on questionnaires answered by all persons were analyzed by logistic regression. Results: The results showed urinary Ca, Zn and serum Cu levels of the study group to be significantly higher (P<0.05) than those of he control group. Serum Ca and Se levels of study group were significantly lower (P<0.05) than those of control group. Conclusion: There were higher urinary Zn and serum Cu concentrations in bladder carcinoma cases. Bladder carcinoma may be associated with Ca metabolic disorder, leading to higher urinary Ca and lower serum Ca. Low serum Se and smoking appear to be other risk factors for bladder carcinoma in China.
Keywords
Trace elements; atomic absorption; bladder carcinoma; risk factor; China;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Wallace K, Kelsey KT, Schned A, et al (2009). Selenium and risk of bladder cancer: a population-based case-control study. Cancer Prev Res (Phila), 2, 70-3.   DOI
2 Yelinova V, Glazachev Y, Khramtsov V, et al (1996). Studies of human and rat blood under oxidative stress: changes in plasma thiol level, antioxidant enzyme activity, protein carbonyl content, and fluidity of erythrocyte membrane. Biochem Biophys Res Commun, 221, 300-3.   DOI
3 Zhai H, Chen X, Hu Z (2003). Study on the relationship between intake of trace elements and breast cancer mortality with chemometric methods. Comput Biol Chem, 27, 581-6.   DOI
4 Zeegers MP, Kellen E, Buntinx F, et al (2004). The association between smoking, beverage consumption, diet and bladder cancer: a systematic literature review. World J Urol, 21, 392-1.   DOI
5 Akcay T, Saygili I, Andican G, et al (2003). Increased formation of 8-hydroxy-2'-deoxyguanosine in peripheral blood leukocytes in bladder cancer. Urol Int, 71, 271-4.   DOI   ScienceOn
6 Costello LC, Franklin RB (2006). The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots. Mol Cancer, 5, 17.   DOI
7 Arslan M, Demir H, Arslan H, et al (2011). Trace elements, heavy metals and other biochemical parameters in malignant glioma patients. Asian Pac J Cancer Prev, 12, 447-1.
8 Berridge MJ, Bootman MD, Lipp P (1998). Calcium--a life and death signal. Nature, 395, 645-8.   DOI   ScienceOn
9 Brinkman M, Buntinx F, Muls E, ea al (2006). Use of selenium in chemoprevention of bladder cancer. Lancet Oncol, 7, 766-4.   DOI
10 Capiod T, Shuba Y, Skryma R, et al (2007). Calcium signalling and cancer cell growth. Subcell Biochem, 45, 405-7.   DOI
11 Christudoss P, Selvakumar R, Pulimood AB, et al (2012). Zinc and zinc related enzymes in precancerous and cancerous tissue in the colon of dimethyl hydrazine treated rats. Asian Pac J Cancer Prev, 13, 487-2.   DOI
12 Daniel KG, Harbach RH, Guida WC, et al (2004). Copper storage diseases: Menkes, Wilsons, and cancer. Front Biosci, 9, 2652-2.   DOI
13 Demir C, Demir H, Esen R, et al (2011). Altered serum levels of elements in acute leukemia cases in Turkey. Asian Pac J Cancer Prev, 12, 3471-4.
14 Egan KM, Signorello LB, Munro HM, et al (2008). Vitamin D insufficiency among African-Americans in the southeastern United States: implications for cancer disparities (United States). Cancer Causes Control, 19, 527-5.   DOI
15 Gupta SK, Singh SP, Shukla VK (2005). Copper, zinc, and Cu/ Zn ratio in carcinoma of the gallbladder. J Surg Oncol, 91, 204-8.   DOI
16 Hronek M, Zadak Z, Solichova D, et al (2000). The association between specific nutritional antioxidants and manifestation of colorectal cancer. Nutrition, 16, 189-1.   DOI
17 George GP, Ramesh V, Mittal RD (2011). Impact of total and ionized serum calcium on prostate cancer risk in North Indian men. Asian Pac J Cancer Prev, 12, 1257-0.
18 Hoekstra WG, Suttie JW, Ganther HG, et al (1974). Trace elements metabolism in animals, vol 2. University Park Press, Baltimore, p 61.
19 Huang YL, Sheu JY, Lin TH (1999). Association between oxidative stress and changes of trace elements in patients with breast cancer. Clin Biochem, 32, 131-6.   DOI
20 Han Y, Zhang Z, Zhang GJ, et al (2011). Aberrant FHIT expression is linked to bladder carcinogenesis and apoptosis. Asian Pac J Cancer Prev, 12, 2915-0.
21 Joazeiro CA, Weissman AM (2000). RING finger proteins: mediators of ubiquitin ligase activity. Cell, 102, 549-2.   DOI   ScienceOn
22 Jemal A, Siegel R, Ward E, et al (2007). Cancer statistics. CA Cancer J Clin, 57, 43-6.   DOI   ScienceOn
23 Knight JA (1998). Free radicals: their history and currentstatus in aging and disease. Ann Clin Lab Sci, 28, 331-6.
24 Li M, Zhang Y, Liu Z, et al (2007). Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A, 104, 18636-1.   DOI
25 Lin CN, Wang LH, Shen KH (2009). Determining urinary trace elements (Cu, Zn, Pb, As, and Se) in patients with bladder cancer. J Clin Lab Anal, 23, 192-5.   DOI   ScienceOn
26 Monteith GR, McAndrew D, Faddy HM, et al (2007). Calcium and cancer: targeting $Ca^{2+}$ transport. Nat Rev Cancer, 7, 519-30.   DOI   ScienceOn
27 McMillan DC, Sattar N, Talwar D, et al (2000). Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer. Nutrition, 16, 425-8.   DOI
28 Mross K (2000). Anti-angiogenesis therapy:concepts and importance of dosing schedules in clinical trials. Drug Resist Updat, 3, 223-5.   DOI
29 Marco' PLM, Jime'nez E, Herna'ndez CEA, et al (2001). Determination of Zn/Cu ratio and oligoelements in serum samples by total reflection X-ray fluorescence spectrometry for cancer diagnosis. Spectrochim Acta, B At Spectrosc, 56, 2195-1.   DOI
30 Nelson RL (1992). Dietary iron and colorectal cancer risk. Free Radic Biol Med, 12, 161-8.   DOI
31 Navarro Silvera SA, Rohan TE (2007). Trace elements and cancer risk: a review of the epidemiologic evidence. Cancer Causes Control, 18, 7-27.   DOI
32 Rayman MP (2005). Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc, 64, 527-2.   DOI   ScienceOn
33 Spartz L, Bloom AD (1992). Biological consequences of oxidative stress: implications for cardiovascular disease and carcinogenesis. Oxford University Press, New York, pp 138-1.
34 Salganik RI, Solovyova NA, Dikalov SI, et al (1994). Inherited enhancement of hydroxyl radical generation and lipid peroxidation in the S strain rats results in DNA rearrangements, degenerative diseases, and premature aging. Biochem Biophys Res Commun, 199, 726-3.   DOI
35 Salehi A, Khezri AA, Malekmakan L, et al (2011). Epidemiologic status of bladder cancer in Shiraz, southern Iran. Asian Pac J Cancer Prev, 12, 1323-7.
36 Smith ML, Lancia JK, Mercer TI, et al (2004). Selenium compounds regulate p53 by common and distinctive mechanisms. Anticancer Res, 24, 1401-8.
37 Skinner HG, Schwartz GG (2008). Serum calcium and incident and fatal prostate cancer in the National Health and Nutrition Examination Survey. Cancer Epidemiol Biomarkers Prev, 17, 2302-5.   DOI   ScienceOn
38 Skinner HG, Schwartz GG (2009). A prospective study of total and ionized serum calcium and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev, 8, 575-8.
39 Trush MA, Kensler TW (1991). An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radic Biol Med, 10, 201-9.   DOI
40 Toyokuni S (1999). Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int, 49, 91-2.   DOI   ScienceOn
41 Tashiro H, Kawamoto T, Okubo T, et al (2003). Variation in the distribution of trace elements in hepatoma. Biol Trace Elem Res, 95, 49-3.   DOI
42 Uriu-Adams JY, Keen CL (2005). Copper, oxidative stress, and human health. Mol Aspects Med, 26, 268-8.   DOI   ScienceOn
43 Valko M, Rhodes CJ, Moncol J, et al (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact, 160, 1-40.   DOI   ScienceOn
44 Willett WC, MacMahon B (1984). Diet and cancer--an overview. N Engl J Med, 310, 633-8.   DOI