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http://dx.doi.org/10.7314/APJCP.2012.13.2.715

Clinico-Pathological Significance of MHC-I Type Chain-associated Protein A Expression in Oral Squamous Cell Carcinoma  

Wang, Jie (Department of Immunology, Xiangya Medical School, Central South University)
Li, Chao (Department of Oral and Maxillofacial Surgery, Xiang Ya Hospital, Central South University)
Yang, Dan (Department of Oral and Maxillofacial Surgery, Xiang Ya Hospital, Central South University)
Jian, Xin-Chun (Department of Oral and Maxillofacial Surgery, Xiang Ya Hospital, Central South University)
Jiang, Can-Hua (Department of Oral and Maxillofacial Surgery, Xiang Ya Hospital, Central South University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.2, 2012 , pp. 715-718 More about this Journal
Abstract
The current research concerns the clinicopathological significance of MHC class I chain-related protein A (MICA) expression in oral squamous cell carcinomas (OSCCs). The expression and location of MICA protein in 14 normal oral mucous and 45 cancerous and para-cancerous tissues were assessed by immunohistochemistry and levels of MICA mRNA expression in 29 cancerous and para-cancerous tissues were determined by the real-time polymerase chain reaction. Data were analyzed with the SPSS16.0 software package. MICA was found to be located in the cytoplasm and plasma membrane. Expression was higher in para-cancerous than in cancerous tissues (P < 0.05). However, no statistical difference was found between the following: 1) para-cancerous tissue with normal mucosa; 2) normal mucosa with cancerous tissue;and 3) among different clinicopathological parameters in OSCC (P > 0.05). The level of MICA mRNA was higher in OSCCs than in para-cancerous tissues, and was correlated with the regional lymph node status and disease stage (P < 0.05). The levels of MICA protein and mRNA expression differ among normal oral mucosa, para-cancerous tissue, and cancerous tissue. MICA may contribute to the tumorigenesis and progression of OSCC.
Keywords
Carcinoma squamous cell; MHC class I-related chain A; immunohistochemistry; polymerase chain reaction;
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