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http://dx.doi.org/10.7314/APJCP.2012.13.2.677

Clinical Significance of Axin and β-catenin Protein Expression in Primary Hepatocellular Carcinomas  

Guan, Cheng-Nong (Department of Oncology, the Affiliated Hospital of Guangdong Medical College)
Chen, Xin-Ming (Department of Oncology, the Affiliated Hospital of Guangdong Medical College)
Lou, Hai-Qing (Department of Oncology, the Affiliated Hospital of Guangdong Medical College)
Liao, Xiang-Hui (Department of Oncology, the Affiliated Hospital of Guangdong Medical College)
Chen, Bao-Ying (Department of Oncology, the Affiliated Hospital of Guangdong Medical College)
Zhang, Pei-Weng (Department of Oncology, the Affiliated Hospital of Guangdong Medical College)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.2, 2012 , pp. 677-681 More about this Journal
Abstract
The aim of the present research was to investigate clinicopathologic correlations of immunohistochemically-demonstrated axin (axis inhibition) and ${\beta}$-catenin expression in primary hepatocellular carcinomas (HCCs), in comparison with paraneoplastic, cirrhotic and normal liver tissues. Variation in Axin expression across groups were significant (P < 0.01), correlating with alpha fetoprotein (AFP), HBsAg, cancer plugs in the portal vein, and clinical stage of HCCs(P < 0.05); however, there were no links with sex, age, and tumour size (P > 0.05). Differences in cell membrane ${\beta}$-catenin expression were also statistically significant (P < 0.01), again correlated with AFP, HBsAg, cancer plugs in the portal vein, and clinical stage in HCCs (P < 0.05) but not with sex, age, and tumour size (P > 0.05). Axin expression levels in tissues with reduced membrane ${\beta}$-catenin were low (P < 0.05), also being low with nuclear ${\beta}$-catenin expression (P < 0.05). Axin and ${\beta}$-catenin may play an important role in the genesis and progression of HCC via the Wnt signal transmission pathway. Simultaneous determination of axin, ${\beta}$-catenin, AFP, and HBsAg may be useful for early diagnosis, and metastatic and clinical staging of HCCs.
Keywords
Axin; ${\beta}$-catenin; hepatocellular; immunohistochemstry;
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1 Ashibara K, Saito T, Mizumoto H, et al (2002). Mutation of beta-catenin gene in endometrialcancer but not in associated hyperplasis. Med Electron Microsc, 35, 9-15.   DOI
2 Daa T, Kashima K, Kaku N, et al (2004). Mutations in components of the Wnt signaling pathway in adenoid cystic carcinoma. Mod Pathol, 17, 1475-82.   DOI
3 Hasegawa T, Yokoyama R, Matsuno Y, et al (2001). Prognostic significance of histologic grade and nuclear expression of beta-catenin in synovial sarcoma. Hum Pathol, 32, 257-63.   DOI   ScienceOn
4 Hino S, Michiue T, Asashima M, et al (2003). Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. J Biol Chem, 278, 14066-73.   DOI
5 Jin L H, Shao QJ, Luo W, et al (2003). Detection of point mutations of the Axin1 gene in colorectal cancers. Int J Cancer, 107, 696-9.   DOI
6 Karim R, Tse G, Putti T, et al (2004). The significance of the Wnt pathway in the patho-logy of human cancers. Pathology, 369, 120-8.
7 Kikuchi A (1999). Roles of Axin in the Wnt signalling pathway. Cell Signal, 11, 777-88.   DOI
8 Liu C, Li Y, Semenov M, et al (2002). Control of beta-catenin phosphorylation/degradation by a Dual-kinase mechanism. Cell, 108, 837-47.   DOI
9 Luo W, Lin SC (2004). Axin: a master scaffold for multiple signaling pathways. Neurosignals, 13, 99-113.   DOI   ScienceOn
10 Nakajima M, Fukuchi M, Miyazaki T, et al (2003). Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma. Br J Cancer, 88, 1734-9.   DOI
11 Neo SY, Zhang Y, Yaw LP, et al (2000). Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin leveks. Biochem Biophys Res Commun, 272, 144-50.   DOI
12 Pirinen RT, Hirvikoski P, Johansson RT, et al (2001). Reduced expression Of $\alpha$-catenin, $\beta$-catenin, and $\gamma$-catenin is associated with high cell proliferative activity and poor differentiation in nonsmall cell lung cancer. J Clin Pathol, 54, 391-5.   DOI   ScienceOn
13 Rubinfeld B, Robbins P, EL-Gamil M, et al (1997). Stailization of $\beta$-catenin by genetic defects in melanoma cell line. Science, 275, 1790-2.   DOI   ScienceOn
14 Rui Y, Xu Z, Lin S, et al (2004). Axin stimulates p53 functions by activation of HIPK2 kinase through Multimeric complex formation. EMBO J, 23, 4583-94.   DOI
15 Satoh S, Daigo Y, Furukawa Y, et al (2000). AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet, 24, 245-50.   DOI   ScienceOn
16 Takahashi M, Tsunoda T, Seiki M, et al (2002). Identification Of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene, 21, 5861-7.   DOI
17 Ueta T, Ikeguchi M, Hirooka Y, et al (2002). Beta-catenin and cyclin D1 expression in human hepatocellular carcinoma. Oncol Rep, 9, 1197-203.
18 Zeng L, Fagotto F, Zhang T, et al (1997). The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axin formation. Cell, 90, 181-92.   DOI
19 Zeng L, Fagotto F, Zhang T, et al (1997). The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell, 90, 181-92.   DOI